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Blood Bank Exam 1 Lecture 1
Blood Bank Exam 1 Lecture 1 Study Material
54
Biology
Undergraduate 3
01/21/2015

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Term
What is Blood Bank?
Definition
Successfully giving people a blood component they lack
Term
Define Immunology
Definition
The process where the body is protected from disease and foreign invaders
Term
Which type of hemolysis is the following:
Cell membrane is destroyed by COMPLEMENT (Not by ABY)
Definition
Intravascular
Term
Which type of hemolysis is the following:
ABY is attached to RBC membrane
Complex is removed by the SPLEEN
Definition
Extravascular
Term
Which type of Immunity is the following:
Involves the production of ABYs by B lymphs that are converted to plasma cells
Definition
Humoral
Term
Once coated with ABY, cell is either destroyed by what 3 things?
Definition
phagocytosis
complement
removed by the spleen
Term
Which type of immunity is the following:
Involves the direct interaction of T lymphs with foreign cells
Definition
Cellular
Term
2 Examples of Cellular Immunity are
Definition
Delayed hypersensitivity
Transplant Immunology
Term
Complement
Definition
Lyses ABY coated cells and serves to mediate opsonization to prepare for phagocytosis by neutrophils and macrophages
Term
Antigens
Definition
Substances capable of inducing a specific immune response
Term
True or False:
AGNs that stick out tend to be More Antigenic
Definition
True
Term
Epitope is the portion of the antigen where....
Definition
the antibody combines
Term
Antigens can be acquired through (4)
Definition
Pregnancy
Inhalation
Injection
Ingestion
Term
Antibodies
Definition
Protein synthesized by plasma cells
Term
2 Types of Antibodies
Definition
Alloantibody
Autoantibody
Term
Alloantibody
Definition
ABY to foreign substances
Term
Autoantibody
Definition
ABY to self
Term
2 Classes of ABYs found in BB
Definition
IgG
IgM
Term
Warm ABYs
Definition
IgG
Term
Cold ABYs
Definition
IgM
Term
True or False:
IgG is naturally occurring
Definition
False
Term
True or False:
IgM is naturally occurring
Definition
True
Term
Specificity
Definition
The ability of an ABY to react with a Specific AGN
Term
First Stage of Antigen-Antibody Reaction is
Definition
Sensitization
Term
Second Stage of Antigen-Antibody Reaction is
Definition
Agglutination
Term
Sensitization
Definition
Recognition Stage
Term
Agglutination
Definition
Agglutination Stage
Term
True or False:
Sensitization stage is a Random Pairing determined largely by Chance
Definition
True
Term
True or False:
For the Sensitization Stage an ABY is attached to AGN on the RBC membrane but a Visible Reaction is NOT observed
Definition
True
Term
An ____ in _____ will Increase the Probability of Collision
Definition
Increase
Antibody
Term
What 3 things may influence the probability for collision in the Sensitization stage?
Definition
ABY concentration
AGN Receptor accessibility
AGN Receptor concentration
Term
4 Environmental Factors that influence the Sensitization stage
Definition
Incubation time
Temperature
pH
Ionic Strength
Term
Optimal incubation time
Definition
15-60 minutes
Term
IgG reacts at what temperature?
Definition
37 degree Celsius
Term
IgM reacts at what temperature?
Definition
Room Temperature or lower
Term
Optimal pH
Definition
7.0
Term
After sensitization the ABY-coated RBCs are necessary to develop __________ for the visualization of RBC clumping
Definition
Crosslinkages
Term
Agglutination forms when RBCs are in close proximity to promote ____ formation between the ABY and Antigenic sites on adjacent RBCs
Definition
Lattice
Term
What 3 things influence the Agglutination Stage?
Definition
Distance between the RBCs
Optimal concentrations of ABYs and AGNs
Effect of Centrifugation
Term
Zeta Potential
Definition
The force or repulsion between RBCs in a physiologic saline solution
Term
RBCs possess a net _____ charge on the cell surface in a saline suspension
Definition
Negative
Term
Cations ( ______ charge) from the saline environment are attracted to these charges on the RBCs
Definition
Positive
Term
True or False:
The distance between the RBCs is proportional to the zeta potential
Definition
True
Term
Effect of IgM
Definition
The larger size, pentameter shape and multivalent properties easily facilitates agglutination between RBCs that have it attached
Term
Effect of IgG
Definition
ABY is smaller and less able to span the distance between adjacent RBCs generated by the zeta potential
Term
True or False:
IgG may be attached but visible agglutination may not occur
Definition
True
Term
Maximum agglutination is observed by the concentration of AGNs and ABYs which fall within the _____ ___ _____
Definition
zone of equivalence
Term
Prozone
Definition
ABY excess
Term
Postzone
Definition
AGN excess
Term
What does centrifugation help to facilitate?
Definition
the formation of a lattice network
Term
____ and ____ of centrifugation aid in the detection of agglutinated RBCs
Definition
Time
Speed
Term
In addition to agglutination, what else may ACTIVATE COMPLEMENT
Definition
an antigen-antibody reaction
Term
What type of response is the following:
Takes 5-7 days
More IgM
Nees more AGN to stimulate
Definition
Primary
Term
What type of response is the following:
Takes 24-48 hours
Total titer is higher
Titer lasts longer
Mostly IgG
Memory B cells
Delayed hemolytic transfusion Reaction
Definition
Secondary
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