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Block III-Endo
Hormones
5
Physiology
Professional
07/13/2009

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Term
GH(somatotropin)
Definition

Origin: Ant. Pit.

Structure: Protein

Regulated: Stim-GHRH

Inhib-Somatostatin

F(x): growth of bone and cartilage;increase protein synthesis in body;lipids to FA for energy;decrease use of glucose as energy source which raises glucose levels resulting in increased glycogen storage.

Excess: Symmetric gigantism in children and acromegaly in adults

Deficiency: In children causes symmetrical dwarfism.

Term
How does GH act on the liver?
Definition
Indirectly by inducing liver to produce somatomedins(protein growth factors).
Term

How does malnutrition effect GH?

 

Definition
Increased levels of blood glucose or aminos, as it occurs in malnutrition, stimulates the pituitary to stimulate the secretion of GH, thereby restoring lost tissue proteins 
Term
Negative Feedback control of GH
Definition

Somatomedin production inhibit GH production by;

1)direct action on AP

2) secretion of somatostatin from hypothalamus

3)GHRH from hypo. inhibits its own secretion 

Term
PRL(prolactin)
Definition

ORIGIN: AP(acidophil cells)

STRUCTURE: Protein

REG: PRH(stim) and ESPECIALLY PIF(inhib)

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