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Block 7 Exam 1
hematology
34
Histology
Post-Graduate
01/28/2013

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Term
blood
Definition
specialized connective tissue consisting of free cells and a fluid intercellular matrix
Term
plasma
Definition
55% of blood volume. water with dissolved proteins and inorganic salts.
Term
Wrights stain
Definition
most commonly used blood stain. RBCs pink. WBC cytoplasm blue, nuclei dark blue.
Term
RBCs
Definition
specialized for O2 transport. lose nucleus, ER, golgi, centrioles, most mitochondria. bag of Hb.
Term
rouleaux
Definition
RBCs adhering to each other via concaved surfaces to form long rows
Term
size of RBCs
Definition
7micrometers
Term
reticulocytes
Definition
newly released RBCs that still contain some RNA which gives diffuse basophilia to cytoplasm
Term
WBCs
Definition
true cells with nucleus. arise, function, and die in connective tissues. just utilized blood as means of transport.
Term
active amoeboid movement
Definition
allows passage through blood vessel walls into connective tissues
Term
lymphocytes
Definition
prominent purple staining nucleus with only a small amount of pale staining cytoplasm
Term
B lymphocytes
Definition
differentiate into plasma cells, manufacture and secrete antibodies
Term
T lymphocytes
Definition
various immune functions
Term
monocytes
Definition
characterized by kidney shaped nucleus with very fine granules in the cytoplasm. differentiate into macP after exiting bloodstream.
Term
granulocytes
Definition
lobed nuclei with granules
Term
neutrophils
Definition
2-6 lobes. chemotactically drawn to infection. anaerobic via glycogen supply. phagocytize dead cells. major component of pus.
Term
drumstick
Definition
extension from lobes in some neutrophils from females contains inactivated X chromosome.
Term
eosinophils
Definition
bi-lobed. red granules. most common in intestinal and respiratory mucosa. indicate parasites or allergic. phagocytize Ag/Ab complexes.
Term
basphils
Definition
purple granules. precursor to mast cells. release histamine and other vasoactive mediators during immediate hypersensitivity or anaphylactic response.
Term
platelets
Definition
biconvex disc. 2-4micrometers. formed from megakaryocytes. 3 types of granules. cytoskeletal filaments. component of intrinsic clotting mechanism. release serotonin which is a vasoconstrictor.
Term
unitarian theory
Definition
all blood cells derived from a common cell called a hemocytoblast
Term
dualistic theory
Definition
one stem cell for granulocytes and another stem cell for all other blood cells
Term
hemopoiesis
Definition
occurs in bone marrow. cell size decreases. nucleus eccentrically located prior to expusion. cytoplasm becomes increasingly larger constituent of cell and changes from highly basophilic due to ribosomes to eosinophilic due to Hb
Term
erythropoietin
Definition
made by kidney. increase in response to hypozia. controls hematopoiesis
Term
hematopoiesis in adules
Definition
marrow cavities of flat bones
Term
hematopoiesis in embryonic development
Definition
first yolk sac, then liver, then spleen, the bone marrow
Term
RBC life span
Definition
127 days
Term
macP of spleen, liver, BM
Definition
remove Hb retaining fragments and senile RBCs from circulation. break down to billirubin and iron. iron recycled as feritin or hemosiderin. bilirubin sent to liver to be excreted with bile
Term
granulocytopoiesis
Definition
precursor cells represent 60% of BM cells. spend less time in blood (6-10 hrs). short functional lifespan (10 days in connective tissue).
Term
order of granulocytopoesis
Definition
myloblast>>specific promylocyte>>mylocyte>>metamylocyte>>band(stab) cell>>granulocyte
cell size decreases, nucleus becomes smaller and eventually forms lobes. granules appear at mylocyte stage.
Term
life cycle of lymphocytes and monocytes
Definition
formed in bone or lymphatics. long life span.
Term
monocytes
Definition
live several months
Term
lymphocytes
Definition
live many years. can enter, leave, and re-enter blood stream many times
Term
platelets
Definition
formed in bone marrow.
Term
megakaryocytes
Definition
have limited life span. replaced via differentiation of uncommitted stem cells. dead ones can enter circulation, especially in pathology and form embolism.
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