Term
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Definition
| "When an axon of cell A...excites cell B & repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells so that A's efficiency in firing cell B is increased" |
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Term
| When studying Hebb's postulate, what do we look at? |
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Definition
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Term
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Definition
| "long term potentiation" (strengthening of the synapse) |
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Term
| Why have LTP been most researched in the hippocampus? |
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Definition
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Term
| In the LTP experiments, what is the presynaptic & what is the postsynaptic cell? |
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Definition
presynaptic = CA3 axon
postsynaptic = CA1 dendrite |
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Term
| Experiment: single test stimulus at 100 Hz (100 pulses per second) for 0.5 - 1 second (very not natural scenario but good for learning about LTP!) about every 30 seconds --> ? |
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Definition
| about 30 minutes later, the EPSP will increase in size after stimulation |
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Term
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Definition
1. early LTP (after about 30 minutes, you start to see an increase in EPSP size lasting about 2-3 hours & then will go back to original size)
2. late LTP (tends to last about 5-6 hours) |
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Term
| a burst of stimuli is called a ______ |
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Definition
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Term
| What is the implication with there being multiple axonal pathways to the same postsynaptic cell? |
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Definition
| you could apply tetanus to one axonal pathway & get the LTP, but when you apply tetanus to a different axon pathway & you won't get the LTP |
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Term
| What is the implication of input specificity? |
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Definition
| the change won't spread to other synapses |
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Term
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Definition
| a bunch of EPSPs (stimulating presynaptic axons repeatedly) reaching an action potential |
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Term
| depolarization indicates a _____ synapse |
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Definition
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Term
| stimulating CA3 axon --> release ? |
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Definition
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Term
| 2 things that have to happen simultaneously to get the LTP (coincidence detection) |
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Definition
1. you need a glutamate release due to presynaptic depolarization
2. you need postsynaptic cell to be sufficiently depolarized to get rid of the magnesium block |
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Term
| LTD _____ the strength of the synapse |
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Definition
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Term
| stimulation on CA3 occurs at 1 Hz for 900 seconds --> ? |
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Definition
| EPSP that you started with will be smaller |
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Term
| Is blocking NMDA receptors or getting rid of intracellular calcium the way to get an LTD instead of an LTP? |
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Definition
| no! (you still increase calcium with LTD timing) |
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Term
| The LTD process can be altered by the presence of ______ |
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Definition
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Term
| stimulating presynaptic neuron & then stimulating the postsynaptic neuron --> ? |
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Definition
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Term
| stimulating postsynaptic neuron & then stimulating the presynaptic neuron --> ? |
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Definition
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Term
| What really matters to depend on whether you get LTP or LTD? |
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Definition
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Term
| Can depolarization spread up through the soma & through the dendrites & move backwards? |
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Definition
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