Term
| Septic Arthritis, Non Gonococcal Bacteria |
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Definition
| monoarticular, acute hyperplasia synovial lining, septic until proven otherwise, possible irreversible joint damage if management delayed; ESR and CRP usually elevated; IV antibiotics, drain joint |
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Term
| Septic Arthritis, Disseminated Gonococcal Infection |
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Definition
| monoarticular, presents with triad of polyarthralgias (no arthritis), dermatitis, tenosynovitis or purulent arthritis alone; Culture synovial fluid and orifice swab; Drain purulent joints and start antibiotics first IV then oral |
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Term
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Definition
| monoarticular, from parvovirus B19, Hep C, HIV |
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Term
| Crystal Arthropathy, Gout |
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Definition
| monoarticular, often in peripheral joints, hyperuricemia, warm swollen joints, assoc. with tenosynovitis, increase or decrease in uric acid cause flare up, crystals may still be found in intercritical asymp periods; Polarizing microscopy of neg-birefrin urate crystals reveals yellow when parallel to plane and blue when perpendicular; acute- colchicines and NSAIDS, chronic-allopurinol and probencid |
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Term
| Crystal Arthropathy, CPPD-Psuedogout |
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Definition
| formed in cartilage, shedded, directly inflammatory to synovium, warm/swollen joints, occurs in women/elderly, affects large joints like wrist/knee, can present as chondroncalcinosis or synovitis; aspirate joint to find pos. birefringment crystals; colchicines, NSAIDs, steroids, treat like gout |
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Term
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Definition
| poly, inflamm, symmetric, varying extraarticular involvement, Rh. Nodules, swelling, effusion, ulnar deviation, Swan/Boutouniere/Mutilans, tendon ruptures, vasculitis; Rh factor and Anti-CCP(for fillagrin), ANA/Synoial fluid not diagnotistic, Imaging shows osteopenia, sublux, narrowing; DMARD’s, methotrexate, TNF-inhib, NSAIDs |
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Term
| Systemic Lupus Erythematous |
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Definition
| autoantibodies and immune comlexes create organ damage, malar rash/oral ulcer/nephritis/CNS(psychosis), female/UV/drugs/virus increase risk; Test anemia of chronic disease, + ANA/Anti-phospho/Smith/SSA-SSB; NSAID, Hydroxychloroquinone |
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Term
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Definition
| poly, inflamm, symmetric, exocrine glands of eyes and mouth infiltrated by lymphocytes(CD4) to epithelium, can be with SLE/RA/Sclerosis, middle-age women mostly, increase risk of lymphoma; + Anti-SSA/SSB antibodies or RF, lymphocytes on biopsy; artificial tears, oral hygiene, pilocarpine |
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Term
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Definition
| poly, inflamm, symmetric, excessive collagen deposition causing vascular stenosis, thick skin, organ damage, hypertension, renal failure, pulmonary fibrosis, acrolysis, classified based on level of skin thickening - diffuse worse than limited (CREST-Calcinosis,Reynauds,Esophageal,Sclero,Teledots); + ANA Anticentromere, Anti-SLC70; Treat symptoms |
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Term
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Definition
| inflammatory infiltrative process that results in necrosis of vascular wall and thus ischemia to region, increase risk with Hep B/C and autoimmune and drugs; + ANCA; steroids do not help |
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Term
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Definition
| poly, inflamm, asymmetric, Seronegative (Rh-), joint fusion of sacroiliac and vertebral joints, hip/shoulder arthritis, no skin problems, subclinical GI, iritis; 90% + HLA-B27; Treat stiffness and pain, ROM PT |
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Term
| Reactive Arthritis/Reiter’s Syndrome |
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Definition
| poly, inflame, asymmetric, Seronegative, develops after infectious process that is not septic to the joints, affects peripheral joints and sacro/spinal joints, psoriasis-like rash, GI involvement when pathogen initiated, conjunctivitis, young adults, enthesitis/dactylitis/oral lesions/plaque on palms and soles; 20-80% +HLA-B27; NSAID’s, antibiotics, HIV test |
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Term
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Definition
| poly, non-inflam cool effusion, degenerative, softening and erosion of cartilage, osteophytes, subchondral cysts, joint space narrow, Bouchards/Herbedens; Imaging; Acetaminophen, then NSAIDs, topicals, joint injections, narcotics |
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