Term
| What labeled AA do we use to determine if gout is from purine overproduction vs. impaired excretion? |
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Definition
| 15N-laybeled glycine (forms core of purine) |
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Term
| How does allopurinol inhibition work? |
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Definition
| It is a suicide inhibitor of xanthine oxidase. It is converted to oxypurinol in the process. |
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Term
| Pyrimidine degradation products? |
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Definition
C----(deamination)--->U--->Beta-alanine, CO2, & NH4+
T ------> Beta-aminoisobutyrate, CO2, & NH4+ |
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Term
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Definition
-uses zidovudine, ZDV, (AKA azidothymidine AZT) which is a dTMP analog
-Works because it is missing the 3' OH group
-Specifically targets reverse transcriptase |
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Term
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Definition
-Functions as a ribozyme
-Used in prokaryotes to cleave transcripts to produce smaller rRNAs, specifically 16S, 25S, & 5S rRNA. (Also some tRNAs) |
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Term
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Definition
-Uses rifampin of the rifamycin family
-Works by selectively inhibiting bacterial RNA pol
-Can inhibit mit RNA pol in high amounts |
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Term
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Definition
-Rare heritable disorder called Li-Fraumenti syndrome
-Associated with multiple types of tumors
-AUTO DOM because even tho it is a loss of function, there only needs to be one more "hit" to be complete loss of function |
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