Term
| other name of hereditary hemorrhagic telangiectasia |
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Definition
| Osler-Weber-Rendu disease |
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Term
| Heriditary hemorrhagic telangiectasia/Osler-Weber-Rendu disease |
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Definition
| Congenital disease due to increased vascular fragility |
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Term
Ehlers-Danlos disease
type of dieases |
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Definition
| Congenital disease due to increased vascular fragility |
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Term
Henoch-Scholein
type of disease |
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Definition
| Acquired disease due to increased vascular fragility |
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Term
inherited tendancy to microvascular dilatiions in skin, mucosa, GIT
AUTOSOMAL DOMINANT |
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Definition
| Hereditary hemorrhagic telangiectasia/Osler-Weber-Rendu disease |
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Term
| inherited mesenchymal defect w/ impaired formation of collagenous support of BV walls |
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Definition
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Term
Allergic pupura associated w/ joint pain and GIT symptoms.
Generalized vasculitis w/ deposition of immune complexes in blood vessels and within glomerular mesangial regions. |
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Definition
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Term
| 10,000 - 20,000 cu.mm causes |
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Definition
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Term
| aplastic anemia, marrow depressive drugs, lukemia/infiltrative malignant cells (thiazides, cytotoxic drugs) |
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Definition
| Decreased platelet production |
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Term
1)drugs
2) Infections (mono, HIV)
3) auto - immine ITP, SLE
4) consumption DIC, TTP, MAHA |
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Definition
| Decreased platelet survival |
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Term
| kills platelets by autoimmune mechanism |
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Definition
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Term
| reduces platelets by consumption |
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Definition
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Term
| X linked inhierited disorder w/ increased platelet destruction, small platelets, eczema, and immunodeficiency |
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Definition
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Term
| Autosomal recessive inheirited Neonatal thrombocytopenia |
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Definition
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Term
bone marrow failure -> reduced platelets (RBC macrocytosis), skin hypopigmentation, hyperpigmentation, short stature
microcephaly, micropthalmia (smallbrain, small eyes) |
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Definition
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Term
| ^ destructin of platelets from alloimmunization to HPA-1a and other platelet specific antigens |
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Definition
| NAIT (Neonatal alloimmune Thrombocytopenia) |
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Term
IgG antibodies on surface of platelets
spleen is site of destruction and creation of ABs.
decrease in platelets, increase in bleeding time, increase in Megakaryocytes in BM. |
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Definition
| Idiopathic Thrombocytopenic Purpura (ITP) |
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Term
in children disease is acute and seen after viral infections
chronic form = young adult women
may be first manifestation of SLE |
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Definition
| Idiopathic Thrombocytopenic Purpura (ITP) |
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Term
| Thrombotic Thrombocytopenic Purpura (TTP) and Hemolytic Uremic Syndrome (HUS) are |
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Definition
| Thrombotic Microangiopathies |
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Term
| Characterized by fever, thrombocytopenia, MAHA, renal failure, and neurological deficits |
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Definition
| Thrombotic Thrombocytopenic Purpura (TTP) |
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Term
| onset in childhood, no neuro defects, acute renal failure more predominant feature, usually follows GI infections (E Coli/Shigella) hamburgers |
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Definition
| Hemolytic Uremic Syndrome (HUS) |
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Term
Commonly seen in females, no evidence of previous bacterial infections.
get neuro problems, renal probs, fever, thrombocytopenia, MAHA |
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Definition
| Thrombotic Thrombocytopenic Purpura (TTP) |
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Term
defect is in platelet ADHESION
platelets are giant
Inherited Hemorrhagic disease |
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Definition
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Term
Defect is in platelet AGGREGATION
Inherited
Hemorrhagic disease |
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Definition
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Term
| NSAIDS/Aspirin can lead to |
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Definition
| Acquired Hemorrhagic Diseases due to defective platelets |
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Term
Autosomal Recessive
Defect in Gp1b (platelet to vWF)
childhood epistaxis, mucosal bleeding
defect w/ ADHESION |
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Definition
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Term
Autosomal Recessive
defect - GP complex GpIIb/IIIa mediates platelet aggregation/formation of solid plug |
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Definition
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Term
| Least common of the myeloproliferative disorders which also include CML, myelofibrosis, polycythemia vera |
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Definition
| Essential Thrombocythemia (Idiopathic Thrombocythemia) |
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Term
Bone marrow shows MK hyperplasia w/ marked platelet production
tons of platelets in blood but some giant and abnormal, AGGREGATE SHITTY |
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Definition
| Essential Thrombocythemia (Idiopathic Thrombocythemia) |
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Term
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Definition
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Term
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Definition
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Term
| Hemophilia A and B are both |
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Definition
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Term
PTT is prolonged
but bleeding time normal and platelet count normal in |
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Definition
| Hemophilia A and Hemophilia B |
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Term
| Most common hemophilia type disorder |
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Definition
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Term
| Von Willebrand Disease I and II are both |
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Definition
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Term
| Von Willebrand Disease III is |
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Definition
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Term
| The worst kind of von willebrand disease is this one, the VWF is absent basically |
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Definition
| Von Willebrand disease III |
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Term
unlike hemophilia bleeding into joint spaces uncomon.
characterized by epistaxis menorrhagia, rapid onset of abnormal bleeding after surgery or trauma |
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Definition
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Term
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Definition
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Term
| decrease in VWF decreases |
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Definition
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Term
| characterized by REDUCED QUANTITY of circulating vWF |
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Definition
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Term
| characterized by QUALITATIVE DEFECT in vWF |
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Definition
| Von Willebrand disease II |
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Term
| vit K def. leads to lack of factors... |
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Definition
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