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Biosystems II
Helminths
20
Biology
Graduate
03/08/2012

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Term
helminths
Definition
-multi cellular (intestinal/tissue)
-sexual reproduction
-digestive, execretory, nervous
-requires intermediate and definite host
Term
3 helminths
Definition
-nematodes (roundworms/intestinal)
-cestodes (tapeworms/intestinal)
-trematodes (flukes/tissue)
Term
helminth diseases
Definition
-required a high worm burden
-no direct human human transmission
-adult worm infections not eliminated by host response (respond to eggs/larvae/antigens)
Term
helminth transmission
Definition
-ingestion or penetration with eggs/larvae
-topical/subtopical
-socioeconomic conditions
-food practices and consumption
-live in intestines and deeper tissue
-release eggs in fecal material; no replication in host (exception Strongyloides)
Term
cestoda
Definition
-tapeworms
-true parasite
-no vascular, respiratory, digestive system
-absorb nutrients across surface
-scolex
-strobila
-proglottids
-
Term
scolex
Definition
-head with sucking discs for attachment
Term
strobila
Definition
long segmented body
Term
proglottids
Definition
-hermaphroditic reproductive units
-sheds eggs through terminal
Term
tapeworm life
Definition
-eggs in pork, beef, fish
-undercooked meat releases in intestine
-can last 25 years and 10 meters
Term
Nematode treatment
Definition
-Mebendazole-wide spectrum
-bind and interfere with glucose uptake and MT polymerization
-selective for nematodal isoform of B-tubulin
Term
Nystatin/Amphotericin B
Definition
-formation of pores, disrupt membrane
-inhibit ergosterol synthesis
Term
Azole compounds
Definition
-inhibit synthesis of lanosterol (precursor of ergosterol)
Term
intestinal helminths
Definition
-ascaris
-enterobius
-taeniasis
Term
ascaris
Definition
-nematode acquired by ingestion of embryonic eggs
-produce intestinal/bilary obstruction, peritonitis
Term
enterobius
Definition
-nematode acquired by ingestion of embryonic eggs
-causes itching of perianal or genital region
Term
taeniasis
Definition
-cestode acquired by ingestion of larval cysts
-beef, pig, fish reservoirs
-typically asymptomatic
Term
nematodes
Definition
-roundworms
-complex body
-separate sexes
-directly penetrate or passed on thought intermediate host
Term
ascaris lumbricoides
Definition
-large roundworm
-eggs must incubate in soil
-coughed up in lungs then swallowed
-pneumonia like symptoms
Term
enterobius vermicularis
Definition
-pinworm
-infective eggs on perianal skin
-no incubation needed
Term
cestode treatment
Definition
-praziquantel-increases permeability of cell membrane to calcium resulting in paralysis and contracture
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