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Biopharmacy
just shoot me
34
Science
Professional
11/13/2008

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Term
Absoulte Bioavailability
Definition
F = (AUC of X / Dose of X ) / (AUC of IV / Dose of IV)
Term
Relative Bioavailability
Definition
RBA = (AUC of X / Dose of X ) / (AUC of Reference / Dose of Reference)

RBA = F of X / F of reference
Term
Partition Coefficent
Definition
K = (solubility in lipid) / (solubility on water)
Term
Ka = (in terms of acids & bases)
Definition
Ka = {Base * Proton Concentration) / Acid

Ka = ([A-][H+]) / [HA]

Ka = ([B][H+]) / [BH+]
Term
pKa
Definition
pKa=-log(Ka)
Term
Ka = (in terms of pKa)
Definition
Ka = 10^-pKa
Term
Flick's Law
Definition
dQ/dt = (DAK(change in concentration))/h

Papp=DK/h so...

(dq/dt)/A = Papp(change in concentration)
Term
Henderson Hasselback
pH =
Definition
pH = pKa + log(base/acid)
pH = pKa + log (A-/HA)
pH = pKa + log (B/BH+)
Term
fraction unionized
Definition
fraction base unionized = B / B + BH+
Term
Michales Menten
Definition
V = (Vmax[drug])/[drug] + Km
Term
Noyes Whitney
Definition
dm/dt = (DS/h)(Cs-Ct) = DSCs / h
Term
When pH = pKa St =
Definition
St = 2So
Term
St (acid) =
Definition
St = So(1+(Ka/H+))
Term
St (base) =
Definition
St = So (1 + (H+/Ka))
Term
if St < So then ...
Definition
there is an error in the calculation
Term
if St > Smax then...
Definition
the answer is Smax
Term
Theraputic Window =
Definition
MTC / MEC
Term
Hydrophilic Interaction
Definition
lipid /w lipid, water /w water
Term
Flick's Law Variables
Definition
D = diffusion coefficent
A = surface area
K = partition coefficent
h = membrane thickness
Papp = permability coefficent
Term
free =
Definition
unionized
Term
Ratio:
Definition
describes the relative abundance of one specie to another
Term
Increases Passive Diffusion Rate
Definition
1. Greater concentration gradient
2. iincrease partition coefficent (Papp = DK/h)
3. increase the fraction of unionized drug
Term
Km =
Definition
Km = 1/2 Vmax
Term
Vmax is dependent upon
Definition
1. ability of carrier transport to move molecules
2. number of transporters
3. number of cells in the membrane
Term
St = (words)
Definition
ion + unionized form
Term
Intrinsic Solubility
Definition
So, unionized form, HA or B
Term
Smax =
Definition
Smax = Intrinsic Solubility + Ion Solubility
Term
Concentration of the Bulk Solvent
Definition
Total drug dissolved / total volume
Term
Decrease h by
Definition
mixing
Term
Decrease D by
Definition
increasing voscosity, increasing molecule radius, or decreasing the temperature
Term
+ heat of solution
Definition
molecules absorb heat while disolving, the temperature of the solvent decreases. can speed up the process by heating the mixture.
Term
- heat of difusion
Definition
molecules release heat into the solvent as they dissolve, can cool the solvent to speed up the process
Term
polymorphism
Definition
more than one crystal form
Term
dielectric constant
Definition
measure of solvents ability to separate ions of electrlytes. increasing the solvent polarity increases the dielectric constant
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