Term
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Definition
| Absorption, Distribution, Metabolism, Excretion (Toxicity) |
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Term
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Definition
| measurement of the rate and extent (amount) of systemic absorption of the drug |
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Term
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Definition
| study of the relation of the physical and chemical properties of a drug to its bioavailability, pharmacokinetics, and pharmacodynamic and toxicologic effects |
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Term
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Definition
| the proportionality term between rate of elimination of drug from the body and plasma drug concentration, with units of flow (e.g., mL/min or L/hr); also defined as the volume of blood effectively cleared completely of drug per unit time. |
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Term
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Definition
| group of tissues with similar blood flow and drug affinity, not a real physiologic or anatomic region; a space in which a drug or metabolite appears kinetically to be located |
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Term
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Definition
| a model in which the body is characterized by one or more spaces into which drug appears kinetically to be distributed |
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Term
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Definition
| fate of the drug after administration; all kinetic processes (distribution and elimination) that occur to a drug once a drug entered the systemic circulation |
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Term
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Definition
| movement of drug to and from the various tissues and organs of the body via the blood |
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Term
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Definition
| a systematic manner of administration of a drug intended for the treatment or amelioration of a disease or condition |
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Term
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Definition
| irreversible loss of drug from the site of measurement; occurs by two processes: excretion and metabolism |
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Term
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Definition
| irreversible loss of chemically unchanged drug from the body; urinary excretion is the most common pathway |
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Term
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Definition
| time for the concentration or amount of drug to fall by one half |
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Term
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Definition
| conversion of one chemical species to another |
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Term
| Metabolic interconversion |
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Definition
| conversion of metabolites back to the drug; becomes a route of drug elimination only to the extent that the metabolite is excreted or otherwise irreversibly lost from the body |
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Term
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Definition
| mathematical description of a biologic system, used to concisely express quantitative relationships |
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Term
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Definition
| study of cellular and molecular interactions of drugs with their receptors; the relation of the drug concentration or amount at the site of action (receptor) and its pharmacologic response |
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Term
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Definition
| the application of genomic information to the identification of drug targets and to an understanding of the causes of genetic variability in drug response; refers to a combination of genes with effect on drug response |
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Term
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Definition
| study of the time course of drug movement in the body during absorption, distribution and elimination (excretion and biotransformation) |
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Term
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Definition
| process by which a drug proceeds from the site of administration to the systemic circulation where it is measured |
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Term
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Definition
| the overall clearance of the drug from the body, represented by the sum of all organ clearance |
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Term
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Definition
| blood or plasma drug concentration is a measure of systemic exposure to a drug |
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Term
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Definition
| the degree of separation within an individual between a regimen that is beneficial and tolerable and one that is limited by the adverse effects produced; it is low when the degree of separation between the two is small |
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Term
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Definition
| the range of exposures to a drug associated with successful therapy |
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Term
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Definition
| the apparent volume into which a drug distributes in the body at equilibrium, or the volume of plasma needed to account for the amount of drug in the body at equilibrium |
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