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| combination of DNA and protein molecules |
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| formed when chromatin coils up which is about to divide-contains cell's DNA |
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| before DNA divides, it duplicates its chromosomes, forming identical copies which are _______. |
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| cell division occurs; Mitosis and Cytokinesis |
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| division of the nuclei of cells-equal distribution of chromosomes into daughter nuclei |
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| cytoplasm divides in cells |
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| Prophase, Metaphase, Anaphase, Telophase |
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| chromosomes condense, mitotic spindle forms (spindle apparatus composed of microtubules) that moves that chromosomes |
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| chromosomes move to the equator of the cell |
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| sister chromatids separate and move to opposite poles |
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| cell begins to divide-mitotic spindle breaks down-cytokinesis occurs |
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| Most normal cells divide only when attached to a surface |
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| Density Dependence Inhibition |
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| cells continue dividing until they touch one another |
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| divide excessively and can invade other tissues and displace normal cells |
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| abnormal mass of cells-benign do not spread, malignant (cancerous) can |
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| growth of cancer cells beyond original site |
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| cancers that originate in the external linings of the body (skin) |
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| cancers in tissues that support the body-bone and muscle |
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| cancers in blood forming tissues-bone marrow, spleen, lymph nodes |
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| used to destroy dividing cells-targets cancer cells but can destroy normal cells |
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| drugs that disrupt cell division (ex: taxol-impairs the function of the mitotic spindle-discovered in the bark of the Pacific Yew) |
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| produces genetic variety among offspring-inherit chromosomes from each parent |
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| carry genes controlling the same characteristics-different genes code for different variations of characteristics |
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| different versions of genes that code for different variations of characteristics |
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| determine gender; female: XX, male: XY |
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| two homologous sets of chromosomes (2n) in humans the number is 46 (2n=46) |
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| single set of chromosomes; n=23 in humans |
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| when egg and sperm cell fuse; 2n=46 |
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| cell division that forms gametes-reproductive organs |
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| in synapsis, homologous chromosome pairs come together and form a tetrad. These pairs exchange segments (crossing over). Spindle forms-tetrads start to move towards the center of the cell |
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| homologous chromosomes align on the metaphase plate |
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| homologous chromosomes separate and move towards opposite poles |
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| chromosomes arrive at opposite ends of the cell and the cell divides in cytokinesis |
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| chromosomes align in the center of cell (metaphase plate) |
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| sister chromatids separate and move to the opposite poles of the cell |
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| chromosomes arrive at opposite poles and cytokinesis begins-forms 4 haploid cells when complete |
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| Independent Assortment (Independent Orientation) |
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| each pair of homologous chromosomes orients itself on the metaphase plate independently of other pairs in Meiosis I |
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| the exchange of corresponding segments between 2 homologous chromosomes-adds to genetic variability |
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| the production of gene combinations different from those on the original chromosomes-result of crossing over |
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| physical traits; ex: yellow seeds |
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| first generation of offspring |
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| offspring of F1 generation |
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| the expression of 2 different alleles of a gene in a heterozygote (both genes are dominant) ex: blood type |
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| alleles at a single locus may have effects on two or more traits |
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| Mutation in gene for fibrillin (connective tissue) effects skeleton, cardiovascular system, lungs, eyes and skin (Pleiotropy) |
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| traits affected by genes at more than one loci |
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| continuous range in a given trait among individuals; the more genes a trait is affected by, the more _____________ |
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| contains master gene for sex determination; if present testes form; contains very few genes |
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| more genes than Y chromosome, many deal with nonsexual trains; genes can be expressed in both males and females |
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| chart of genetic connections among individuals; used to follow traits in humans through generations and determine the genotypes of individuals |
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| Trait is carried on the x chromosome; appears in males more than females, males cannot inherit from his father; ex: colorblindness, hemophilia |
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| Autosomal Recessive Inheritance |
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| two recessive alleles must be present for trait to be displayed |
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| parents may be carriers; albinism, sickle cell disease |
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| carried on dominant alleles; ex: achondroplasia, Huntington's disease |
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| special type of dominant disorder, arises as the result of a spontaneous mutation |
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| 1 more or 1 fewer chromosomes than normal; many miscarriages are _______ |
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| extra chromosome where 21st pair of homologous chromosomes is normally located |
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| chromosome pairs or sister chromatids fail to separate=causes abnormal number of chromosomes in gametes |
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| XXY-individual is usually sterile, feminine characteristics |
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| XO-sterile, short stature, webbing of the neck |
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| females with XXX, limited fertility |
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| DNA (deoxyribonucleic acid) |
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| polymer composed of nucleotides; contains instructions for how to build proteins |
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| phosphate group, nitrogenous base, 5-carbon sugar |
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| attaches complementary nucleotides |
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| joins fragments on lagging strand |
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| nucleic acid; has uracil instead of thymine |
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| carries protein building instructions from the nucleus to the ribosome |
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| delivers amino acids to the ribosome |
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| single strand of mRNA is formed from a DNA template |
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| composed of 3 nucleotide bases found on the mRNA, these triplets of bases code for specific amino acids=genetic code; 61 different ones; 3 are stop ____ |
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| tRNAs attach to amino acids in the cytoplasm and bring them to the ribosome; tRNAs have anticodons that complement the codons on the mRNA; tRNA attached to the amino acids bind to the mRNA strand bringing the amino acid to the ribosome in the process; amino acids are strung together to make polypeptides that compose proteins |
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