Term
| Sorting signals/ Traffic signals |
|
Definition
| short stretches of amino acid sequences that direct proteins to their correct cellular location |
|
|
Term
| Most eukaryotic cells begin their synthesis on ______ in _______, using ______. |
|
Definition
|
|
Term
|
Definition
| proteins destined for ER, Golgi, lysosome, vacuole, plasma membrane or secretion are first directed to the ER. |
|
|
Term
| Post-Translational Sorting |
|
Definition
Uptake of most proteins into the nucleus, mitochondria, chloroplasts, and peroxiomes occurs after the protein is completely made.
Sorting happens AFTER translation is finished. |
|
|
Term
| To be directed to the rough ER membrane, a polypeptide must contain a sorting signal called __________. This brings the unformed polypeptide into the ER. |
|
Definition
|
|
Term
| Signal Recognition Particle (SRP) |
|
Definition
| RNA/protein complex that recognizes the ER signal sequence and pauses translation. Then, binds to a receptor in ER membrane and leaves ribosome over a channel protein. SRP is released and translation resumes. |
|
|
Term
|
Definition
| For proteins meant to function in the ER. Also contain ER signal sequence. |
|
|
Term
|
Definition
| Enzyme that cleaves ER signal sequence once polpeptide has entered ER. |
|
|
Term
|
Definition
| Help a vesicleto bud from a given membrane. Coat is shed, after released from membrane. Involved in 2nd step of cotranslation. |
|
|
Term
|
Definition
| Incorporated into the vesicle membrane and are recognized by t-snares; fuses with the t-snares. |
|
|
Term
|
Definition
starts in RER-> Medial Golgi
process of covalently attaching a carbohydrate to a protein (Glycoprotein) or a lipid (glycolipid) |
|
|
Term
|
Definition
| dye binds to the POLAR head groups of phospholipids but NOT fatty acyl tails |
|
|
Term
|
Definition
1. 2 long chains of fatty acids
2. activation by CoA
3. + Glycerol-Phosphate (charged)
4. Acyl Transferase inserts this into ER membrane on C-Leaflet side
5. Phosphotase removes phosphate
6. Choline phosphate added to glycerol by phosphatranferase
7. Flippase flips to other membranes |
|
|
Term
|
Definition
Nitrogen-Asparagine-X-serine/threonine
x can NOT be proline
dolichol + oligosaccharide
destination: plasma membrane in cell surface |
|
|
Term
|
Definition
ONLY in GOLGI
usually part of PROTEOGLYCANS (extracellular matrix)
=addition of sugars to oxygen aton of SERINE or THREONINE side chains |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
