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Biology Lecture 7
The Cytoskeleton
17
Biology
Undergraduate 1
10/08/2009

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Term
Actin
Definition
  • Motor protein that makes up the microfilament
Term
Alpha Tubulin
Definition
dimmer that makes up the tubulin protein
Term
ATP
Definition
An adenine-containing nucleoside triphosphate that release free energy when it's phosphate bonds are hydrolyzed. This energy is used to drive endergonic reaction in cells.
Term
Beta-tubulin
Definition
a dimmer of tubulin
Term
Cell motility
Definition
  • interaction of cytoskeleton with motor proteins and plasma membrane help cell move along fibers outside cell.
  • motor proteins that attach to receptors on vesicles can "walk" the vesicles along microtubules or microfilaments
Term
Cilia
Definition
  • cilia
    • occurs in large numbers in each cell
    • beating pattern
      • work like oars, with alternating power and recovery strokes generating force in a direction perpendicular to the ciliums axis.
Term
Cytoskeleton
Definition
  • a network of fibers extending through the cytoplasm
  • made up of 3 types of molecular structures
    • microtubules- thickest
    • microfilaments- thinnest
    • intermediate filaments- middle
  • gives cell mechanical support and shape
  • stabalized by a balance between opposing forces exerted by it's elements
  • anchorage for many organelles and cytosolic enzyme molecules
  • can be dismantled and reassembled
  • manipulates the plasma membrane in a way that forms food vacuoles or other photogocytic vesicles
  • transmit forces exerted by extracellular molecules via cell surface proteins
  • center for cell motility
Term
similarities between cilia and flagella
Definition

both

  • a core of micrtubules sheathed n an extension of the plasma membrane
  • 9+2 pattern
    • 9 doublets of microtubules
    • each pair sharing part of their walls
    • in a ring
    • 2 single tubules in the middle
  • 9+0 pattern
    • non motile because the dont have microtubules in the middle
    • anchored by basal body similar to centriole
  • felxible cross-linking proteins, evenly spaced along the length of cilium or flagellum, connect the outer doublets to each other and to 2 central microtubules
  • outer doublet has piors of protruding proteins, called dynein, spaced along its length and reach neighbor doublet
  • energy provided by ATP
  • unrestrained by cross-linking
    • dynien bending resembles walking
    • if a doublet passes the other it just looks longer
  • cross-linking protein
    • cannot slide past eachother very fast and so they bend
    • the protein holds them back
Term
Dynein
Definition
  • Large motor protein
  • each composed of polypeptides
  • help organelle bend
  • crosslinking proteins
    • spaced along outer doublet stretched along it's length that reach neighbor doublet
Term
Flagella
Definition
  • singular flagellum
  • microtubule- containing extensions that project from some cells
  • occurs in small numbers
  • beating pattern
    • udulating motion that generates force in same direction as the flagellums axis
Term
Intermediate Filaments
Definition
  • Specialized for braring tension
  • consistent in diameter and composition in a all eukaryotic cells 8-12nm
  • made of severak different proteins of the keratin family depending on cell type
  • permanent fixtures always retains original shape
  • important in reinforcing the shape of cell and anchoring the position of certain organelles and nucleus
  • formation of nuclear lamina
Term
Keratin
Definition
The protein of hair, horns, feathers, and other skin appendages
Term
Microfilaments
Definition
  • 7 nm
  • built from actin protein
  • twisted double chain of actin subunits
  • may form structural networks
  • present in all eukaryotic cells
  • functions:
    • to bear tension
    • changes in cell shape
    • muscle contraction
    • cytoplasmic streaming
    • cell motility (as in pseudopia)
    • cell division (cleavage furrow formation)
  • 3 dimensional network of microfilaments inside plasma membrane helps support the cells shape
Term
Microtubules
Definition
  • Hollow tubes; wall consist of 13 columns of tubulin molecules
  • 25nm with 15nm lumen
  • made of tubulin, a dimer consisting of alpha-tubulin and beta-tubulin
  • functions
    • maintenance of cell shape (compression-resisting girders)
    • cell motility (cilia or flagella)
    • chromosome movements in cell division
    • organelle movements
Term
Motor proteins
Definition
  • interact with cytoskeleton during cell motility
  • bring about the bending of cilia and flagella by gripping microtubules within those organelles and sliding them against each other
Term
Myosin
Definition
A type of protein filament that acts as a motor protein with actin filaments to cause cell contraction
Term
Tubulin
Definition
  • protein that makes up microtubules
  • made up of alpha tubulin and beta tubulin dimers

 

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