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Biology Ch. 1 - The Cell
MCAT
38
Biology
Undergraduate 1
05/25/2016

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Term
What are the 4 basic tenets of cell theory?
Definition
  • All living things are composed of cells
  • The cell is the basic funcitonal unit of life
  • Cells arise only from preexisting cells
  • Cells carry genetic information in the form of DNA. This genetic material is passed on from parent to daughter cell
Term
Features of eukaryotes
Definition
  • membrane-bound organelles
  • nucleus
  • can form multicellular organisms
Term
What is the function of the cytosol?
Definition
suspends the organelles and allows diffusion of molecules throughout the cell
Term
nucleus
Definition
  • contains DNA organized into chromosomes
  • surround by the nuclear membrane
Term
nuclear membrane
Definition
surrounds nucleus contains nuclear pores for two way exchange of materials between the nucleus and cytosol
Term
nucleolus
Definition
subsection of nucleus where ribosomal RNA is synthesized
Term
mitochondria
Definition
contain an inner and outer membrane; inner membrane is folded into cristae and contains enzymes for the electron transport chain; divides independently by binary fission; can trigger apoptosis by releasing mitochondrial enzymes
Term
lysosomes
Definition
contain hydrolitic enzymes that can break down substances ingested by endocytosis and cellular waste products; if enzymes released causes autolysis
Term
endoplasmic reticulum
Definition
series of interconnected membranes continuous with the nuclear envelope; rough ER has ribosomes to translate proteins, smooth ER is used for lipid synthesis and detoxification
Term
Golgi apparatus
Definition
stacked membrane-bound sacs in which cellular products can me modified, packaged, and directed to specific cellular locations
Term
peroxisomes
Definition
contain hydrogen peroxide and can break down very long chain fatty acids via β-oxidation; involved in phospholipid synthesis and pentose phosphate pathway
Term
cytoskeleton
Definition
provides stability and rigidity to the overall structure of the cell, while also providing transport pathways for molecules within the cell
Term
microfilaments
Definition
composed of actin, provide structural protection for the cell and can cause muscles interactions with myosin; help form the cleavage furrow during cytokinesis in mitosis
Term
microtubules
Definition
composed of tubulin, they create pathways for motor proteins like kinesin and dynein; contribute to structure of cilia and flagella
Term
centrioles
Definition
found at centrosome and organized microtubules in the mitotic spindle
Term
centrosome
Definition
region of the cell where centrioles can be found
Term
centromere
Definition
part of the region on the chromosome that link two sister chromatids together
Term
intermediate filaments
Definition
involved in cell-cell adhesion or maintenance of the integrity of the cytoskeleton; they help anchor organelles; common examples are keratine and desmin
Term
epithelial tissue
Definition
covers the body and lines its cavities, protecting against pathogen invasion and desiccation; may absorb or secrete substance and participate in sensation
Term
parenchyma
Definition
the functional part of an organ, often made up of epithelial cells
Term
connective tissues
Definition
support the body and provide a framework for epithelial cells; in most organs they form the stroma (support structure) by secreting mateials to form an extracellular matrix; bone, cartilage, tendons, ligaments, adipose tissue, blood
Term
nucleoid region
Definition
found in prokaryotes, where their DNA is concentrated
Term
archaea
Definition
often extremophiles; have similarities with bacteria and eukaryotes
Term
What are the three main bacterial shapes?
Definition

cocci - spherical

bacilli - rod-shaped

spirilli - spiral

Term
Gram positive vs. Gram negative bacteria
Definition

gram positive bacteria have a thick cell wall of peptidoglycan and lipoteichoic acid

gram negative have thin cell wall composed of peptidoglycan and an outer membrane containing lipopolysaccharides

Term
How do prokaryotes multiply?
Definition
Through binary fission, in which the chromosome replicates while the cell grows in size, until it is big enough to split in two
Term
episomes
Definition
plasmids that can integrate into the genome
Term
conjugation
Definition
the transfer of genetic material from one bacterium to another across a conjuagtion bridge
Term
transduction
Definition
the transfer of genetic material from one bacterium to another using a bacteriophage as a vector
Term
transposons
Definition
genetic elements that can insert into or remove themselves from the genome
Term
What are the phases of bacterial growth?
Definition
lag phase, exponential (log) phase, stationary phase, death phase
Term
capsid
Definition
protein coat on a virus
Term
bacteriophage
Definition
virus that infects bacteria
Term
positive sense RNA
Definition
can be translated by the host cell
Term
negative sense RNA
Definition
a complementary strand must be synthesized using RNA replicase
Term
What are the two specific life cycles of the bacteriophage?
Definition

lytic cycle - the bacteriophage produces massive numbers of new virions until the cell lyses

Lysogenic cycle - virus integrates into the host genome as a provirus, or prophage, which can then reproduce along with teh cell. The provirus then leaves the genome in response to a stimulus at some later time and enters the lytic cycle

Term
prions
Definition
infectious proteins that trigger misfolding of other proteins, usally converting to an alpha-helical structure to a beta-pleated sheet
Term
viroids
Definition
plant pathogens that are small cirlces of complementary RNA that can turn off genes, resulting in metabolic and structural derangments of the cells and potentially death
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