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Biology 3
Chapters 8,9,10,11,12,13,14,18
179
Biology
Undergraduate 2
10/21/2011

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Term
Asexual reproduction
Definition
the creation of genetically identical offspring by a single parent, without the participation of sperm and egg.
Term
Chromosomes
Definition
The structures that contain most of the organism's DNA
Term
Sexual reproduction
Definition

Generally resemble their parents more closely than they resemble unrelated individuals of the species

Term
Cell division
Definition
Reproduction of cells. In asexual, allows reproduction. In sexual, allows development, growth, and repair
Term
Binary fission
Definition
A type of cell division by which prokaryotes (bacteria and achaea) reproduce. "Dividing in half".
Term
Life cycle
Definition
The sequence of stages leading from the adults of one generaton to the adults of the next.
Term
Genome
Definition
A set of genetic information
Term
Binary fission in a prokaryote
Definition
  1. chromosomes duplicate and move to the other side of the cell
  2. cell elongates, chromosome duplcation continues
  3. chromosome duplication is complete, cell is 2x its initial size, plasma membrane grows inward and divides into 2 daughter cell
Term
Chromatid
Definition
A diffuse mass of long, thin fibers, which is a combination of DNA and protein molecules.
Term
Sister chromatid
Definition
2 copies of a chromosome which contains copies of the DNA molecule
Term
Centromere
Definition
2 chromatids that joined together especially tightly at a narrow "waist".
Term
Cell cycle
Definition
An ordered sequence of events that extends from the time a cell is first formed from a dividing parent to its own division into 2 cells.
Term
Interphase
Definition
The time when a cell's metabolic activity is very high and the cell performs its various funstion within the organism. There's a high supply of proteins, growth in size, last for about 90% of time during cell cycle.
Term
The three subphases of Interphase
Definition
  1. G1 phase
  2. S phase
  3. G2 phase
Term
G1 phase
Definition
First subphase of interphase in which cell grows.
Term
S phase
Definition
Second subphase of Interphase in which each chromosome begins with each chromosome being single, then it's duplicated and consists of sister chromatids (synthesis of DNA). 
Term
G2 phase
Definition
Third subphase of Interphase in which cell grows as it completes preparation for cell division.
Term

Mitotic phase

(M phase)

Definition
The part of the cell cycle when the cell actually divides. This accounts for 10% of cell cycle.
Term
2 stages of mitotic phase
Definition
  1. mitosis
  2. Cytokinesis
A combination of the two makes 2 genetically indentical daughter chromosomes. Each daughter cell can move into G1 and repeat cycle.
Term
Mitosis
Definition
The nucleus and its contents, including the duplicated chromosomes, divide and evenly distributed to formed 2 daughter nuclei. 
Term
Cytokinesis
Definition
The cytoplasm divides in two
Term
The five stages of Mitosis
Definition
  1. Prephase
  2. Prometaphase
  3. metaphase
  4. anaphase
  5. telophase
Term
Mitotic spindles
Definition
A football-shape structure that guides the separation of 2 sets of daughter chromosomes in animals cells that contain centrioles.
Term
Centrosomes
Definition
Clouds of cytoplasmic material in animal cells that contain centrioles.
Term
Stages of cell division
Definition
  1. Interphase
  2. Prophase
  3. Prometaphase
  4. Metaphase
  5. Anaphase
  6. Telophase
  7. Cytokinesis 
Term
Prophase
Definition
The changes occur in both the nucleus and cytoplasm.
Term
Prophase within nucleus
Definition
The chromatid fibers coil tightly and fold, forming discrete chromosomes; nucleoi disappear; duplicated chromosomes appear as 2 sister chromatid joined together.
Term
Prophase within cytoplasm
Definition
The mitotic spindles form as microtubules grow to form centrosomes. Then they move away from each other.
Term
Prometaphase
Definition
The nucleus envelope breaks into fragments and disappears. The microtubules from the ends of centrosomes reach chromosome. Each sister chromatid has a kinetochore that chromosome into motion. Other spindle micotubule make other one by coming from opposite end and forces chromosomes into center of cell.
Term
Kinechore
Definition
protein?
Term
Metaphase
Definition
Mitotic spindle is fully formed and centrosomes (poles) are at each end. All chromosomes convene on metaphase plate. Kinechores of the sister chromatids force opposite poles.
Term
Metaphase plate
Definition
An imaginary plane between both poles of spindle.
Term
Anaphase
Definition
2 centromeres of each chromosome come apart and separate sister chromatids, which turns it into a daughter chromosome. Kinechores move daughter chromosome centromere along microtubule toward opposite of cell. Cells elongate and poles move apart because there's a collection of chromosomes at each end.
Term
Telophase
Definition

Reverse of prophase.

Cell elongation continues. Daughter nuclei appear at two poles of cell as nuclear envelope form around the chromosomes. The chromatid fibers uncoil; nucleoi reappears and mitotic spindle disappear.

Term
Cytokinesis 
Definition

Division of cytoplasm.

This usually occurs during telophase. 2 daughter cells separate at the end of mitosis.

 

Term
Cleavage
Definition
process in animal cells where cytokinesis occurs.
Term
Cleavage furrow
Definition
A shallow groove in the cell surface. Cytoplasm has a ring of actin microfilaments
Term
Characteristics of cancer cells
Definition
  1. Cells don't respond normally to cycle control system
  2. Cells divide excessively. 
  3. Invade other tissues of the body
Term
Tumor
Definition
abnormally growing mass of body cells
Term
Benign tumors
Definition
A lump of abnormal cells that remain at their original site.
Term
Malignant tumor
Definition
Tumor that can spread into neighboring tissues and other parts of the body. They secrete signal molecules that cause vessels to grow toward the tumor.
Term
Metasis
Definition
The spread of cancer cells via the circulatory system beyond the original site.
Term
Carcinomas
Definition
Cancers that originate on the external or internal coverings of the body.
Term
Sacronomas
Definition
Cancers that arise in tissue that support the body, such as bone and muscle.
Term
Leukemias and Lymphomas
Definition
Cancers that are blood-forming tissue, such as bone marrow, spleen, and lymph nodes.
Term
Somatic cells
Definition
A typical body cell that has 46 chromosomes.
Term
Homologus chromosomes
Definition
2 chromosomes composing a pair, each carrying genes that control the same inherited characteristics.
Term
Locus
Definition
Paricular place on a one chromosome.
Term
Sex chromosome
Definition
Chromosome that determine on individual's sex.
Term
Autosome
Definition
The other 22 pairs of chromosomes.
Term
Diploid cell
Definition
Any cell with 2 homologus sets of chromosomes.
Term
Gamete
Definition
Egg and sperm cell.
Term
Haploid cell
Definition
Single cell with a single set of chromosomes
Term
Meiosis
Definition
A type of cell division that produces haploid gametes in diploid organisms. After duplication of chromosomes there is meiosis I and meiosis II. It's need for sexual reproduction and yields 4 haploid cells from 2 nuclear divisions.
Term
5 Stages of Meiosis
Definition
  1. Interphase
  2. Prophase I
  3. Metaphase I
  4. Anaphase I
  5. Telophase I and Cytokinesis
Term
Interphase
Definition
First stage of Meiosis in which chromosomes consist of 2 genetically indentical sister chromatids attached together.
Term
Prophase I
Definition
Second stage of Meiosis that accounts for 90% of meiotic cell division. Chromatid coils up and synapses occurs, which results in a tetrad. Chromosome condense as nucleoli disappears. Spindles start to form, nuclear envelope breaks, and tetrads move into the center.
Term
Metaphase I
Definition
Chromosomes tetrads are aligned on metaphase plate. Chromosome is condensed and thick, spindle microtubule are attached to kinechores at centromere. Homologus chromosomes of each terad are poised to move toward poles of the cell.
Term
Anaphase I
Definition
Fourth stage of meiosis in which migration of chromosome toward the 2 poles of the cell and tetrads split up.
Term
Telophase I and Cytokinesis
Definition
Fifth stage of meiosis in which chromosome arrive at the ples of cell. Each pole has a haploid chromosome which consist of 2 sister chromatids.
Term
The 4 stages of Meiosis II
Definition
  1. Prophase II
  2. Metaphase II
  3. Anaphase II
  4. Telophase II
Term
Prophase II
Definition
The first stage of Meiosis II in which spindle forms and moves the chromosome toward the middle of cell.
Term
Metaphase II
Definition
The second stage in Meiosis II in which chromosomes align on metaphase plate.
Term
Anaphase II
Definition
The third stage of Meiosis II in which centromeres of sister chromatids finally separate, then move to opposite poles.
Term
Telophase II
Definition
The fourth stage of Meiosis II in which the nuclei forms at cell poles. Cytokinesis occurs and results in 4 daughter cells.
Term
Crossing over
Definition
An exchange of corresponding segments between 2 homologus chromosomes.
Term
Chiasma
Definition
A place where 2 homologus chromatids attach to each other, which starts in early prophase I of meiosis.
Term
How crossing over leads to genetic recombination
Definition
  1. DNA molecule of 2 sister chromatids break at the same place.
  2. 2 broken chromatids come together in a new way, which creates a hybrid of combinations between maternal and paternal genes
  3. Homologus chromosomes separate at Anaphase I
  4. Meiosis II - sister chromatids separate and go to different gamete.
Term
Gene recombination
Definition
The production of gene combinations different from those carried by the original chromosome
Term
Karotype
Definition
A display of magnified images of an individual's chromosomes in pairs, starting with the longest.
Term
Trisomy 21
Definition
Three 21 chromosomes, total of 47 chromosomes.
Term
Down syndrome
Definition

Extra copy of chromosome 21. Characteristics include round face, heart defect, shorter life span.

Happens to 1 in 2,000 people.

Term
Nonjunction
Definition
Occasional mishap in which the members of a chromosome pair fail to separate.
Term
Deletion
Definition
A fragment of a chromosome that is lost.
Term
Duplication
Definition
A fragment from one chromosome that joins to a sister chromatid or homologus chromosome.
Term
Character
Definition
Heritable feature that caries among individuals.
Term
Trait
Definition
Each variant for a character.
Term
Hybrid
Definition
Offspring of two different varieties.
Term
Hybridization
Definition
Cross- fertilization itself.
Term
P (parental) generation
Definition
True-breeding parental plants
Term
F1 generation (filial)
Definition
Hybrid offspring
Term
F2 generation
Definition
F1 plants self fertilize
Term
Monohybrid cross
Definition
Parent plants only differ in one character. 3:1 ratio
Term
Mendel's 4 hypothesis
Definition
  1. Alernative version of genes that account for variations inherited characters, which means ALLELES
  2. for each character, an organism inherits 2 alleles; one from each parent.
  3. The 2 alleles of an individual pair
  4. Law of segregation
Term
Homozygote (Homozygous)
Definition
An organism that has 2 identical alleles for a gene.
Term
Heterozygote (Heterozygous)
Definition
An organism that has two different alleles for a gene.
Term
Dominant allele
Definition
An allele that displays in the organism's appearance.
Term
Recessive allele
Definition
A allele that has no noticible effect on the organism's appearance. 
Term
Law of segregation
Definition
Mendel's law that states, when a sperm and egg unite at fertilization, each contributes its allele, restoring the paired condition in offspring. 
Term
Phenotype
Definition
An organism's expressed, or physical traits.
Term
Genotype
Definition
An organism's genetc make-up.
Term
Dihybrid cross
Definition
Mating of parental varieties differing in 2 characteristics.
Term
Law of independent assortment
Definition
Law that states, each pair of alleles segregates independently of other pairs of alleles during gamete formation.
Term
Test cross
Definition
A mating between an individual of unknown genotype with a homozygous recessive individual.
Term
Rule of addition
Definition
The sum of the probabilites of the different ways.
Term
Complete dominance
Definition
The dominant allele had the same phenotype effect whether present in one on two copies.
Term
Incomplete dominance
Definition

The reappearance of F1 hybrids that falls between the phenotypes of the 2 parental variables.

1:2:1 in F1 generation.

Term
ABO blood group
Definition
O, A, B, AB
Term
Pleiotropy
Definition
Genes that influence multiple characters.
Term
Polygenic inheritance
Definition
Additive effects of 2 or more genes on a single phenotypic characteristic.
Term
Chromosome theory of inheritance
Definition
Genes occupy specific loci on chromosomes and its chromosomes that undergo segregation and independent assortment during meiosis. 
Term
Linked genes
Definition
Genes located close together on the same chromosome that tend to be inherited together. This doesn't follow Mendel's law of independent assortment.
Term
Recombinant frequency
Definition
The percentage of recombinants.
Term
Sex chromosomes
Definition
A pair of chromosomes that determine an individual's sex.
Term
Sex-linked genes
Definition
Gene on a sex chromosome.
Term
Bacteriophages
Definition
Bacteria eaters, "phages".
Term
Polynucleotide
Definition
Polymer diagram.
Term
The 2 components of nucleotides
Definition
  1. Nitrogenous base
  2. Sugar Base
  3. Phosphate
Term
Nitrogenous bases
Definition
Purines and Pyrimides
Term
Sugar-phosphate backbone
Definition
The repeating pattern of sugar–phosphate–sugar–phosphate.
Term
Why is sugar in DNA a deoxyribose?
Definition
The sugar in DNA is missing an -OH group.
Term
Why is sugar in RNA a ribose?
Definition
The sugar in RNA isn't missing an -OH group.
Term
Purines
Definition
A double-ringed base that includes Adenine and Guanine
Term
Pyrimides
Definition
A single-ringed base that includes Thymine and Cytosine
Term
Double-helix
Definition
The presence of 2 strands
Term
Semiconservative model
Definition
A model for DNA replication that has half of the parental molecule conserved in each daughter.
Term
Origins of replication
Definition
Special sets at which replication of a DNA molecule begins.
Term
Where do sugar's 3' carbon atom attach to?
Definition
-OH group
Term
Where do sugar's 5' carbon atom attach to?
Definition
Phosphate group
Term
DNA polymerase
Definition
Enzymes that link DNA nucleotides to a growing daughter strand.
Term
DNA ligase
Definition
An enzyme that links pieces together into single DNA strand.
Term
Theory of the inheritance of acquired characteristics 
Definition
The theory that states, if you acquire a characteristic in your lifetime, then it will be passed on to you offspring. (DISPROVEN).
Term
Punctuated equilibria vs. gradualism
Definition
Everything goes along steady, then a big change, then back to going along steady VS. changes occur really slowly.
Term
Convergent evolution
Definition
Animal groups that look similar, but compared to one another they're different.
Term
What is the molecular connection between genotype and phenotype?
Definition
The DNA inherited by an organism specifies traits by dictating the synthesis of proteins. Proteins are the links between genotype and phenotype.
Term
Transcription
Definition
The transfer of genetic information from DNA into an RNA molecule
Term
Translation
Definition
The transfer of the information in the RNA into a protein.
Term
Gene-one enzyme hypothesis
Definition
The hypothesis that states, the function of a gene is to dictate the production of a specific enzyme. 
Term
Gene-one polypeptide hypothesis
Definition
A hypothesis that states, the function of a gene is to dictate the production of a all proteins.
Term
What is the bridge between DNA nd protein synthesis?
Definition
The nucleic acid RNA
Term
Triplet code
Definition
The genetic instructions for the amino acid sequence of a polypeptide chain are written in DNA and RNA as a series of codons
Term
Codons
Definition
3-base words that result in amino acids.
Term
Genetic code
Definition
A set of rules giving the correspondence between codons in RNA and amino acids in proteins.
Term
What are start codons?
Definition
AUG and MET
Term
What are stop codons?
Definition
UAA, UAG, and UGA
Term
Promotor
Definition
Nucleotide sequence that signals the start of transcription. It has specific binding sites for RNA polymerase and determines which of the 2 strands of DNA is used as a template in transcription.
Term
3 stages of Transcription phase
Definition
  1. Initiation 
  2. Elongation
  3. Termination
Term
Initiation
Definition
First stage of Transcription phase in which RNA polymerase attaches to promotor, and is start of RNA synthesis. mRNA molecule binds to small ribosomal subunit. Large ribosomal subunit binds to smaller ribosomal subunit, which makes functional ribosome.                
Term
RNA elongation
Definition
Second stage of Transcription phase in which RNA strands separate from DNA strand in order for the other DNA strand to come together in the region already transcribed.
Term
Termination
Definition
The 3rd and last stage of Transcription in which RNA polymerase reaches terminator (which is the sequence of bases in DNA template) and signals the end of gene.
Term

Messenger RNA

(mRNA)

Definition
The kind of RNA that encodes amino acid sequences, which conveys genetic information from DNA to translation machinery of cell.
Term
Where does transcription and translation occur in prokaryotes?
Definition
Transcription and translation occur in the cytoplasm.
Term
Where does transcription and translation occur in eukaryotes?
Definition
Transcription and translation occurs in nucleus.
Term
Exons
Definition
Parts of a gene that are expressed as amino acids. 
Term
Introns
Definition
Internal noncoding regions; intervening sequences.
Term
RNA splicing
Definition
Cutting and pasting RNA
Term

Transfer RNA 

(tRNA)

Definition
A special type of RNA that the cell employs as a molecular interpreter.
Term
Anticodon
Definition
Special triplet of bases that is complementary to codon triplet on mRNA.
Term
Ribosomes
Definition
Organelles in cytoplasm that coordinate the function of mRNA and tRNA and actually make polypeptides. 1 binding site for mRNA and 2 binding sites for tRNA.
Term

Ribosomal RNA 

(rRNA)

Definition
A kind of RNA that makes up for 2 subunits of a ribosome
Term
3 stages of elongation
Definition
  1. Codon recognition
  2. Peptide bond formation
  3. Translocation
Term
Codon recognition 
Definition
Anticodon of an tRNA molecule pairs with mRNA codon in site A.
Term
Peptide bond formation
Definition
Polypeptide separates from tRNA in P site and attaches to tRNA in A site.
Term
Translocation
Definition
P site tRNA leaves ribosome, A site tRNA moves into P site and leaves A site vacant. Stop codon in A site stops elongation and terminates stage of translation.
Term
Mutation
Definition
Any change in the nucleotide sequence of DNA
Term
Base substitution
Definition
The replacement of one nucleotide with another.
Term
Base insertions and deletions
Definition
Adding or subtracting nucleotides that may alter the DNA
Term
Mutagenesis
Definition
The product of mutation.
Term
Spontaneous mutations
Definition
Errors that occur during DNA replication or recombination.
Term
Mutagen
Definition
Mutagen that comes from a physical or chemical agent.
Term
Lytic cells
Definition
Cycle that results with breaking open of host cells and releasing produced viruses.
Term
Lysogenic cycle
Definition
Cycle in which viral DNA replication occurs without destroying the host cell.
Term
Virus reproductive cycle
Definition
  1. RNA enters cytoplasm
  2. Enzyme removes protein coating
  3. Virus enzyme makes complementary strands
  4. Uses new strands to make new viral proteins
  5. Serve as synthesizes new viral genome.
Term
Emerging Virus
Definition
Virus that appear suddenly or are new to medical scientists.
Term
3 processes that help an emerge virus disease
Definition
  1. Mutations
  2. Contact between species
  3. Spread from isolated populations
Term
Reverse Transcription
Definition
Synthesize of RNA on an RNA template and causes retroviruses.
Term
Reverse transcriptase
Definition
An enzyme that catalyzes reverse transcription
Term
Reproduction of Retrovirus
Definition
  1. Reverse transcriptase uses RNA to create DNA
  2. Add a 2nd complementary DNA strand
  3. Double-strand DNA enters cell nucleus and inserts into DNA chromosome and create a provirus.
Term
Viroids
Definition
Small, circular RNA molecules that infect plants.
Term
Bacterial cells
Definition
Divide by replication of bacterial chromosomes and then binary fission.
Term
Transformation
Definition
Uptake of foreign DNA from the surrounding environemt
Term
Transduction
Definition
Transfer of bacterial genes by a phage.
Term
Transduction
Definition
Transfer of bacterial genes by a phage.
Term
Conjunction
Definition
The physical union of cells and the DNA transfe between them. The "male" cell attaches to "female" cell
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