Term
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Definition
| One of them functions as a mitogen (activating cells via TLRs regardless of Ig specificity). The other contains repeating epitopes and extensively cross-links mIg. |
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Term
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Definition
| B cell surface molecule. Binds CD40L to give signal 2 in B cell activation. |
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Term
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Definition
| Th cell surface molecule. Binds CD40 to give signal 2 in B cell activation. |
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Term
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Definition
| Portion of signaling domain that gets phosphorylated, setting off signaling cascade. |
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Term
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Definition
| Contains CD19, CR2 (CD21), and TAPA-1 (CD81). Binds C3d, enhancing the signal. |
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Term
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Definition
| Inhibitory B cell coreceptor. Has ITIM. |
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Term
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Definition
| Portion of signaling domain of CD22 that inhibits signaling cascade. |
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Term
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Definition
| Th cell surface molecule. Binds B7 to give signal 2 in Th cell activation. |
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Term
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Definition
| APC surface molecule. Binds to CD28 to give signal 2 in Th cell activation. |
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Term
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Definition
| T cell zone of lymphoid tissues. |
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Term
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Definition
| B cell zone of lymphoid tissues. |
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Term
| Follicular dendritic cell |
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Definition
| Catch Ag-Ab complexes on their surface so they can be taken up by B cells. |
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Term
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Definition
| MHC genes in humans. MHC II has HLA-B, HLA-C, and HLA-A. MHC I has DP, DQ, and DR. |
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Term
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Definition
| MHC genes in mice. MHC II has IA and IE. MHC I has H-2K, H-2D, and H-2L. |
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Term
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Definition
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Term
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Definition
| Individuals with different alleles and at least one loci. |
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Term
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Definition
| Genetically identical except for one or more alleles. |
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Term
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Definition
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Term
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Definition
| Upregulates Class II MHC on various cell types, but downregulates Class II MHC on B cells. |
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Term
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Definition
| Upregulates Class II MHC on B cells. |
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Term
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Definition
| A nonclassical MHC molecule. Presents nonpeptide antigens to T cells. |
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Term
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Definition
| Associate with Class I and (beta)2m until peptide binds in the RER. This is part of the endogenous pathway. |
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Term
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Definition
| Breaks down proteins in the cytosol into peptides. |
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Term
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Definition
| Remaining piece of invariant chain after low pH and proteases digest invariant chain in the exogenous pathway. |
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Term
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Definition
| Binds to MHC II in RER so that endogenous peptides don't bind to it. |
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Term
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Definition
| Mediates exchange of peptide for CLIP in exogenous pathway. |
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Term
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Definition
| Transports peptide into RER in endogenous pathway. |
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Term
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Definition
| Mediates TCR gene rearrangement. |
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Term
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Definition
| 3 complexes (each composed of 2 chains) that stabilize TCR. Connected by ionic interactions. |
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Term
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Definition
| Binds CD4 and zeta/zeta homodimer to stabilize CD4:MHC II interactions. |
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Term
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Definition
Direct Recognition: foreign MHC + peptide treated like self-MHC + foreign peptide.
Indirect Recognition: foreign MHC taken up and presented on self-MHC as foreign peptide. |
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Term
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Definition
| pre-T(alpha) + everything else pretty much normal |
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Term
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Definition
| Positive selection for T cells that bind MHC effectively (i.e. they find a self MHC + peptide) |
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Term
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Definition
| Negative selection for cells displaying self MHC alone or self MHC + self Ag |
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Term
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Definition
| Gene found only in males. |
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Term
| Current Model for CD4/CD8 Lineage Commitment |
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Definition
| Late in pos. selection phase, CD4 and CD8 are transiently downregulated. CD4 is upregulated - if it can bind, it commits. If not, CD4 is downregulated and CD is upregulated. |
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Term
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Definition
| Regulates ectopic expression of many tissue-specific antigens. Induces tolerance to tissue-specific antigens not found in the thymus. |
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Term
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Definition
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Term
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Definition
| In the Ig-Superfamily; found on endothelial cells |
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Term
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Definition
| Binds zeta chains at ITAMs. |
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Term
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Definition
| Inhibits binding of B7 to CD28. Expressed in activated T cells. |
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Term
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Definition
| Binds APC and T cell, forcibly activating the T cell regardless of specificity. Cytokines and inflammatory response are overproduced leading to toxic shock. |
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Term
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Definition
| Stimulates repeated cell division in activated helper T cells. |
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Term
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Definition
| State of unresponsiveness when signal 2 isn't received. |
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Term
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Definition
| T cell regulator. Downregulates self-reactive T cells. |
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Term
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Definition
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Term
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Definition
| Part of all three pathways. |
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Term
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Definition
| Part of three pathways. Last step in complement pathway. |
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Term
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Definition
| Membrane attack complex. Mediates cell lysis. |
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Term
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Definition
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Term
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Definition
| Tagging it for phagocytosis. |
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Term
| Activation of Inflammatory Response |
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Definition
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Term
| Clearance of Immune Complexes |
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Definition
| C3b binds CR1 on erythrocytes and they travel to liver and spleen for opsonization. |
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Term
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Definition
| Receptor for C3b in opsonization and immune complex clearance. |
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Term
| Regulation of Complement System |
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Definition
| Can be done before assembly of convertase or at assembly of MAC. |
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Term
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Definition
| High endothelial cells. Only present on secondary lymphoids, except for spleen. |
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Term
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Definition
| Binds to B cell coreceptor (specifically the CD21) and to the antigen, enhancing the signal. |
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Term
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Definition
| Bind to mucins during rolling phase of leukocyte migration. Found on leukocytes. |
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Term
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Definition
| Bind to selectins during leukocyte migration. Found on endothelial cells. |
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Term
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Definition
| Binds to Ig-superfamily during adhesion/arrest phase of leukocyte migration. Found on leukocytes. |
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Term
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Definition
| Binds to integrins during adhesion/arrest phase of leukocyte migration. Found on endothelial cells. |
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Term
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Definition
| Leukocyte adhesion deficiency. Neutrophils can't effectively extravasate. |
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Term
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Definition
| On T cell precursor. Binds to notch ligand on thymic stromal cells, allowing commitment to T cell lineage. |
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