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BIOL 3350 Test 1
Test Review 1 for Pathophysiology
60
Biology
Undergraduate 3
12/09/2009

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Term
1. Define Anatomy
Definition
Science of structure of the body and its relationships
Term
2. Define Physiology
Definition
Physical and chemical processes involved in the functioning of the human body
Term
3. Define Metabolism and its two categories
Definition
3. Metabolism is the set of chemical reactions that occurs in living cells to maintain life. Catabolism is cellular respiration and anabolism is the construction of proteins.
Term
4. List the levels of structural organization in increasing order
Definition
chemical, cellular, tissue, organ, organ system,organism
Term
5. Define Homeostasis
Definition
The maintenance of a stable equilibrium in a biological system that opposes external/internal disturbance
Term
6. Define the two feedback mechanisms and give examples of each
Definition
Negative feedback reduces or suppresses a change (like blood glucose levels/ a thermometer); Positive feedback promotes instability (like labor/childbirth). They are not opposite.
Term
7. List the four major components of a negative feedback mechanism
Definition
stimulus, sensor, integrator, and effector
Term
8. Principle of Complementarity of structure and function
Definition
The structure of an organ determines its function
Term
9. Examples of ectoparasites
Definition
Mites, lice, and fleas. They live on and not in the body.
Term
10. Vectors of infectious disease
Definition
Ticks, mosquitoes, biting flies - not confined parasites such as roundworms
Term
11. Define incidence.
Definition
The number of new cases of an infectious disease that occur within a defined population
Term
12. Define Normal Micro Flora
Definition
The bacteria that inhabit the external and internal exposed surfaces of the human body that are normal and harmless
Term
13. Define Opportunistic Pathogens
Definition
Microorganisms that are capable of producing an infectious disease when the health and immunity of the host has been severely weakened by illness, famine, or medical therapy
Term
14. Define Prokaryotes.
Definition
unicellular organisms without a nucleus (i.e. bacteria)
Term
15. Gram Staining is used on
Definition
bacteria
Term
16. Fungi that reproduce by budding.
Definition
Yeast
Term
17. Common symptoms of infectious disease.
Definition
Fever, myalgia (muscular pain), headache, lethargy, and fatigue
Term
18. Define Prodromal Stage.
Definition
when early symptoms first appear
Term
19. Define Nosocomial Infections.
Definition
Nosocomial Infections are infections acquired during hospitalization and are secondary to original condition (i.e. staff)
Term
20. Examples of Diseases caused by exotoxins.
Definition
Diptheria
Term
21. Function of Penicillin.
Definition
Inhibits synthesis of bacteria cell wall
Term
22. Define Broad Spectrum Antibiotics.
Definition
Broad Spectrum Antibiotics are antibiotics that are active against a wide variety of gram-positive and gram- negative bacteria.
Term
23. Describe make up of the Immune System.
Definition
The red bone marrow, thymus, lymph nodes, T and B lymphocytes, and the spleen
Term
24. Define Major Histocompatibility Complex Molecules.
Definition
self-components that the immune system uses to determine self vs. non-self
Term
25. Class I Major Histocompatibility Complex (MHC) location.
Definition
All nucleated cells in the body (mature red blood cells have no nucleus)
Term
26. Define Macrophages.
Definition
"Big Eaters" They engulf and digest foreign particles (an early immune response)
Term
27. Define Cytokines
Definition
Intercellular protein that regulates movement, proliferation, and differiniation of immune and other cells.
Term
28. Immunoglobulins are produced by
Definition
B cells
Term
29. Specific immune mechanisms include
Definition
protection afforded by cell-mediated immunity
Term
30. The most abundant Immunoglobulin
Definition
IgG
Term
31. Immunoglobulins that are involved in allergic and hypersensitivity responses
Definition
IgE
Term
32. "Master Switch" cell in immune system
Definition
CD4+T helper cells
Term
33. Differentiation of T lymphocytes.
Definition
In the thymus
Term
34. Lymphocyte involved in humoral immunity through the production of antibodies.
Definition
B lymphocytes (humoral) (Not T)
Term
35. Define Clusters of Differentiation (CD).
Definition
Surface proteins that act as markers for various T and B cells
Term
36. Function of Lymph Nodes
Definition
Removal of foreign material from lymph channels before proliferation, centers of proliferation and response of immune cells
Term
37. Examples of Active Immunity
Definition
exposure to a pathogenic agent
Term
38. Examples of non-specific defenses
Definition
(antigen tagging is not) tears, skin, stomach, saliva, inflammation, fever, phagocytes, and mucus membranes.
Term
39. Presence of local heat during the inflammatory response is due to
Definition
Increased local blood flow
Term
40. Define Chemotaxis
Definition
Attraction of leukocytes to an injurious agent
Term
41. AIDS is caused by
Definition
HIV
Term
42. How is HlV spread
Definition
Blood, sexual contact, maternal-placental circulation, and breast milk
Term
43. HlV virus directly infects
Definition
CD4+ lymphocytes - the "master switch" cells
Term
44. Describe Neutrophils
Definition
The white blood cell that has the greatest rate of increase during a bacterial infection
Term
45. Describe Macrophages
Definition
They capture and process antigens and present them to lymphocytes
Term
46. Describe the acute phase response during an inflammation
Definition
Increased erythrocyte sedimentation rate, fever, skeletal muscle catabolism increase (not leukopenia)
Term
47. Inflammatory Mediators that contribute to swelling, redness, heat, and pain
Definition
prostaglandins
Term
48. A positive antibody test in an infant indicates
Definition
a prenatally exposed infant with maternal antibodies
Term
49. Define Opportunistic infections
Definition
Opportunistic Infections involve common organisms that normally do not produce infection unless there is impaired immune function.
Term
50. Symptoms of the acute primary infection and primary phase of HIV
Definition
mono-nucleosis-like symptoms w/ sore throat, nausea, lethargy. fever, myalgia, photophobia, and lymphadenopathy
Term
51. Symptoms at the point in which immune system is compromised by HIV
Definition
Malignancies, opportunistic infections, and dormant infections surface
Term
52. Describe the "window phase" of HIV infection
Definition
The time after infection and before detectable antibody levels
Term
53. Describe HIV Type 2
Definition
Endemic in West Africa
Term
54. Most common respiratory opportunistic disease in persons who die with AIDS
Definition
pneumocytis carinii (pneumonia)
Term
55. Ways HIV is [not] transmitted
Definition
insect vectors
Term
56. Infections agents of HIV
Definition
blood, semen, vaginal secretions, breast milk
Term
57. How does HIV infect a cell
Definition
It attaches a surface protein on the viral surface to special receptors on the CD4+T helper cell
Term
58. Most accurate and inexpensive method to Test for HIV
Definition
Screening with an immunoassory (EIA or ELISA), followed by a western blot if assay is positive
Term
59. Describe AIDS dementia complex
Definition
memory loss, difficulty concentrating, euphoria, and lethargy
Term
60. Polymerase Chain Reaction is used to detect
Definition
The presence of viral DNA
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