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Biochemistry
Cellular
67
Biochemistry
Graduate
01/17/2014

Additional Biochemistry Flashcards

 


 

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Term
must be both activated and inactivated for cell cycle to progress
Definition
Cyclin-CDK complexes
Term
Rb and p53 inhibit ___ to ___ phase
Definition
G1 --> S
Term
Rb cancers
Definition
retinoblastoma, osteosarcoma
Term
permanent cells
Definition
remain in G0, regenerate from stem cells
Term
neurons
Definition
permanent
Term
stable (quiescent)
Definition
enter G1 --> G0 when stimulated
Term
hepatocytes
Definition
stable
Term
lymphocytes
Definition
stable
Term
skeletal and cardiac mm
Definition
permanent
Term
RBC
Definition
permanent
Term
labile
Definition
never to go G0, divide rapidly with a short G1
Term
bone marrow
Definition
labile
Term
gut epithelium
Definition
labile
Term
skin
Definition
labile
Term
hair follicles
Definition
labile
Term
RER synthesizes ___ and ___
Definition
proteins and N-linked oligosaccharides
Term
Nissl bodies
Definition
RER in neurons; synthesize neurotransmitters and enzymes
Term
free ribosomes
Definition
unattached, synthesis of cytosolic and organellar proteins
Term
goblet cells and plasma cells have abundant ___
Definition
RER
Term
Steroid synthesis and detox
Definition
SER
Term
liver hepatocytes and adrenal cortex contain abundant ___
Definition
SER
Term
golgi 1) modifies N-oligo on ___ 2) O=oligo on ___ and ___ 3) ___ to proteins for trafficking to lysosomes
Definition
- arg
- ser and the
- mannose-6-phosphate
Term
COP1 direction
Definition
retrograde
Term
COPII direction
Definition
anterograde
Term
I cell disease
Definition
failure of addition of mannose-6-phosphate; coarse facial features, clouded corneas, restricted pint movement, high plasma lysosomal enzymes
Term
catabolism of very long chain FA and AA
Definition
peroxisome
Term
plasmalogesn --> neural tissue in what organelle?
Definition
peroxisome
Term
proteins to be destroyed are tagged with ___
Definition
ubiquitin
Term
MT: 1) dimers of ___ and ___
2) ___ GTP molecules
3) ___ retrograde
4) ___ anterograde
Definition
1- alpha and beta
2- 2
3- dynein
4- kynesin
Term
drugs that act on MT
Definition
-bendazole, griseofulvin, vincristine, paclitaxel, colchicine
Term
chediak higashi
Definition
MT polymerizaiton defect; pyogenic infections, partial albinism, peripheral neuropathy
Term
cilia structure
Definition
( + 2
Term
kartageners
Definition
dyne in arm defect, infertility, bronchiectasis, recurrent sinusitis
Term
filament: microvilli
Definition
actin and myosin
Term
filament: mm contraction
Definition
actin and myosin
Term
filament: cytokinesis
Definition
actin and myosin
Term
filament: adherens
Definition
actina nd myosin
Term
MT are found in
Definition
cilia, flagella, mitotic spindle, axon trafficking, centrioles
Term
vimentin
Definition
CT
Term
desmin
Definition
muscle
Term
cytokeratin
Definition
epithelia
Term
GFAP
Definition
astrocytes, Schwann
Term
neurofilaments
Definition
xons
Term
contents of plasma membrane
Definition
cholesterol and phospholipids
Term
increased cholesterol -->
Definition
increased melting temperature and decreased fluidity
Term
increased saturated FA -->
Definition
increased melting temperature, decreased fluidity
Term
binds K site of Na/K pump
Definition
ouabin
Term
ihibits Na/K pump --> increased Ca
Definition
cardiac glycosides
Term
type I collagen
Definition
bone, skin, tendon, dentin, facia, cornea, wound repair
Term
type II colagen
Definition
cartilage, viterous body
Term
type III
Definition
reticulin, blood vessels, uterus, granulation tissue, skin
Term
type IV
Definition
basement membrane
Term
collagen synthesis inside the cell
Definition
pre-procollagen -> hydroxylation with bit C -> glycoslation to form pro collagen -> exocytosis
Term
collagen synthesis outside fibroblasts
Definition
cleavage of terminal region to form tropocollagen -> covalent lysine-hydroxylysin to make collagen fibrils
Term
collagen type in osteogenesis in imperfecta
Definition
type I collagen
Term
symptoms of osteogenesis imperfecta
Definition
multiple fractures, blue sclerae, hearing loss, dental imperfections
Term
type II osteogenesis imperfecta
Definition
fatal in utero
Term
defective step in collagen synthesis of osteogenesis imperfecta
Definition
preprocollagen -> procollagen
Term
symptoms of ehlers danlos
Definition
hyper extensible skin, bleeding, hyper mobile joints
Term
collagen type in ehlers danlos
Definition
type III
Term
defective step of collagen synthesis in ehlers danlos
Definition
peptide cleavage -> collagen fibrils
Term
collagen defect in alport
Definition
type IV
Term
symptoms of alport
Definition
nephritis and deafness, ocular disturbances
Term
AA in elastin
Definition
proline and glycine
Term
marfan syndrome defect
Definition
fibrillin
Term
alpha 1 antitrypsin deficiency
Definition
panacinar emphysema and cirrhosis
Term
meninto
Definition
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