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Biochemistry Exam 1 LECOM
Chapters 1-5
138
Biochemistry
Graduate
09/09/2012

Additional Biochemistry Flashcards

 


 

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Term

Energy Content in kcal/g and KJ/g

Fat:

Carb:

Protein:

Alcohol:

Definition

Fat:      9 kcal/g and 38 KJ/g

Carb:   4 kcal/g and 17KJ/g

Protein: 4 kcal/g and 17 KJ/g

Alcohol: 7 kcal/g and 29 KJ/g

Term
3 Metabolic routes of Fuels, Vitamins, Minerals, Water, Xenobiotics
Definition

Digestions

Absorption

Transport

Term

Dietary Fuels are Oxidized to form?

Fats:

Carbs: 

Proteins:

Alcohol:

Definition

Fats:         CO2 + H2O

Carbs:       CO2 + H2O

Proteins:              CO2 + H2O + NH4+

 

Alcohol:   CO+ H2O

Term

ATP -> ADP + Pi

Energy is Utilized through (5 ways): ____________

 

 

ADP -> ATP

Energy is produced through (1 way): ___________ 

Definition

Utilized through

Biosynthesis, Detoxification, Muscle Contraction, Ion Transport, Thermogensis

 

Produced by

OXIDATION

Term

4 steps in oxidation of Carbs, lipids, and proteins to produced ATP:

1. Hydrolyzed to form ___ + ____ + ____

2. Then each are degraded to form _________

3. Enters the TCA cycle to form _____ and _____

4. ATP is produced by ______ _______ and released by Electron Transport Chain

Definition

1. Glucose, Fatty Acids, Amino Acids

2. Acetyl CoA

3. NADH2 and FADH

4. Oxidative Phosphorylation

Term

Define + Know how to Calculate

1. RDA:

2. BMR:

3. DEE:

Definition

1. Recommended Daily Allowance

How much you are allowed to consume each day

 

2. Basal Metabolic Rate

Energy needed for daily maintanence of organs

 

3. Daily Energy Expenditure

BMR + Food + Activity

Term

3 Monosaccharides are ___ ____ ____

Provides _____ for cells

3 Disaccharides are ___ ____ ___

______ to produce glucose

3 Polysaccharides are _____ ____ ____

Used for energy _____

Conjugated Carbohydrates are components of the ___ _____

Definition

Glucose, Galactose, Fructose

Provide Energy for cell

Sucrose, Lactose, Maltose

Digested

Starch, Cellulose, Glycogen

Energy Storage

Components of the cell surface

Term

Sucrose breaks down to: Glucose and ______

Maltose breaks down to: Glucose and ______

Lactose breaks down to: Glucose and ______

Definition

Sucrose: Glucose + Fructose

Maltose: Glucose + Glucose

Lactose: Glucose + Galactose

Term

Nitrogen Balance:

Determined by _____ _____

Positive examples: ____ ____ ____

Negative examples: ____ ____

Neutral examples: _______

Definition

Nitrogen Balance:

Determined by Amino acids

Positive examples: Growth, Recovery, Pregnancy

Negative example: Stress, poor-diet

Neutral: general health

Term

3 Major Electrolytes: ___ ___ ___

Electrolytes create ____ gradients, maintain ______, neutralize ______

 

4 Major Minerals: ___ ___ ___ ___

___ and ___ are used for structural components

*____* required or metabolic function of ATP

___ is a component of Hemoglobin in blood

Definition

3 Major Electrolytes: Na+,K+,Cl-

Electrolytes create ion gradients, maintain water-balance, neutralize ion-charges

4 Major Minerals: Ca, P, Fe, Mg

Ca and P are used for structural components

*Mg* required or metabolic function of ATP

Fe is a component of Hemoglobin in blood

Term

4 Dificiencies of Fat Soluble Vitamins

Vitamin A:

Vitamin D:

Vitamin E:

Vitamin K:

Definition

Vitamin A:                    Night blindness

Vitamin D:       Rickets or Osteomalacia

Vitamin E:             Musclular Dystrophy

Vitamin K:       Anemia or Blood clotting

Term

Know the categories of water-soluble vitamins:

1. Energy Metabolism: ___,___,___,___,____

2. Amino Acid Metabolism: ______ includes ___ and ____.

3. RBC/neutral development: _____ and _____

4. Collagen Synthesis: _______

Definition

 

1. Energy Metabolism: Thiamine B1, Riboflavin B2, Niacin B3, Biotin, Pantothenic Acid B5

2. Amino Acid Metabolism: Pyridoxamine B6 includes Pyridoxal and Pyridoxine.

3. RBC/neutral development: Folic Acid and Cobalamin B12

4. Collagen Synthesis: Ascorbic Acid C

 

Term

Deficiencies of water-soluble vitamins:

Energy Metabolism Vitamins

1. Thiamine (B1): ____

2. Riboflavin (B2): ____

3. Niacin (B3): ____

4. Pantothenic Acid (B5): ____

5. Biotin (B7): _______

Definition

 

1. Thiamine (B1): Beriberi or annorexia

2. Riboflavin (B2): Ariboflavinosis

3. Niacin (B3): Pellegra

4. Pantothenic Acid (B5): Irretability and fatique

5. Biotin (B7): Conjunctivitis

 

Term

Deficiencies of water-soluble vitamins:

Amino Acid Metabolism:
1. Pyridoxamine (B6): ____
RBC/neutral development
2. Folic Acid (B9): ____
3. Cobalamin (B12): _____
Collagen Synthesis
4. Ascorbic Acid (C): _____


Definition
1. Pyridoxamine (B6): seborrheic dermatitis
2. Folic Acid (B9): Impaired growth, Megaloblastic anemia
3. Cobalamin (B12): Megaloblastic anemia
4. Ascorbic Acid (C): Scurvy
Term

Problems and deficiencies in:

 

Calcium: _____ and ____

 

Phosphorus: ____loss, ____, ____, and _____

 

Iron: _____ (decreased hemoglobin concention in blood) 

Definition

Calcium: Osteoporosis and Osteomalacia

 

Phosphorus: Bone loss, weakness, anorexia, and pain

 

Iron: Anemia (decreased hemoglobin concentration in blood)  

Term

Name the fate of the mejor fuels in Fed State:

1. Glucose: ____ in the form of glycogen

____ for energy

2. Amino Acids: ____ synthesis

Synthesis of ____ compounds

____ for energy

3. Fats: ____ for energy

____ in the form of Triacylglycerides

Synthesis of membrane _____

Definition

1. Glucose: Stored in the form of glycogen

Oxidized for energy

2. Amino Acids: Protein synthesis

Synthesis of Nitrogen compounds

Oxidized for energy

3. Fats: Oxidized for energy

Stored in the form of Triacylglycerides

Synthesis of membrane lipids

Term

Know what enzymes break down which dietary fuels:

1. Carbs -> monosaccharides

Starch, lactose, and sucrose are broken down by __,___, and ___.

2. Proteins -> Amino Acids

4 enzymes break down protein: ___, ___, ___, and ___.

3. Fats (Triacylglycerols) -> FA and 2-monoglycerols

Fats are broken down in the ____ by _____

Definition

1. Carbs -> monosaccharides

Starch, lactose, and sucrose are broken down by a-amylase,sucrase, and lactase.

 

2. Proteins -> Amino Acids

4 enzymes break down protein: Proteases, Pepsin, Trypsin, and Chymotrypsin.

3. Fats (Triacylglycerols) -> FA and 2-monoglycerols

Fats are broken down in the Pancrease by pancreatic lipase

 

Term

Name the 4 lipoproteins in the blood

1. 

2. 

3. LDL

4.

Definition

Chylomicrons

VLDL

LDL

HDL

Term

4 Lipodproteins and their function

1. _____: made in the epithelial cells.

carries triacylglycerides in the blood

2. _____: made in the liver from glucose.

Carries triacylglycerides in blood

3. LDL: made in the blood.

BAD, contrains high concentrations of _____ and ____.

4. ____: made in liver and ____.

exchanges lipds and proteins with lipoproteins

Returns cholesterol from peripheral tissue to liver.

Definition

1. Chylomicrons: made in the epithelial cells.

carries triacylglycerides in the blood

2. VLDL: made in the liver from glucose.

Carries triacylglycerides in blood

3. LDL: made in the blood. (BAD)

Contrains high concentrations of cholesterol and esters.

4. HDL: made in liver and intestine.

exchanges lipds and proteins with lipoproteins

Returns cholesterol from peripheral tissue to liver.

Term

Explain how oxidation occurs in exerise.

 

Use ____ in blood or _____ in your muscles and liver to make ATP by oxidation of ___ and ___ or converting it to lactate through _____.

Definition
Use Glucose in blood or Glycogen in your muscles and liver to make ATP by oxidation of CO2 and H2O or converting it to lactate through Glycolysis.
Term

Glycogen is stored in the ____ and _____

 

Definition
Glycogen is stored in the LIVER and MUSCLES
Term

Know the destination of Triacylglycerol in the Fed State.

TG are found in the _____ and broken down to 2-monoacylglycerols and Fatty-Acids by _____.

They interact with Bile salts to form ____.

Then interact with Epithelial cells to reform _____.

Next packaged with proteins and ___ to form _____ and are then secreted in the the blood stream..

Definition

TG are found in the Intestines and broken down to Fatty-Acids and 2-monoacylglycerols by pancreatic-lipase.

They interact with Bile salts to form micelles.

Then interact with Epithelial cells to reform TG.

 Next packaged with proteins and cholesterols to form Chylomicrons and are then secreted in the the blood stream.

Term

Know how blood glucose levels regulate the release of insulin and glucagon in the Fed State or Absorptive State

 

Glucose levels High:

Insulin levels ____

Glycogen levels ____

Glucagon levels ____

Definition

Fed State or Absorptive State

 

Glucose levels High:

Insulin levels High

Glycogen levels High

Glucagon levels "Low"

Term

Know the differences and similarities of Hypercholesterolemia, Hyperglycemia, and Hyperlipidemia

1. Hypercholesterolemia: elevated _____ levels

____ type drugs

2.Hyperglycemia: Elevated ____ levels

______ type drugs

3. Hyperlipidemia: Elevated ____ levels

___ type drugs

Definition

1. Hypercholesterolemia: elevated Cholesterol levels

Antihyperlipidemic type drugs

2.Hyperglycemia: Elevated Glucose levels

Insulin type drugs

3. Hyperlipidemia: Elevated Lipid levels

Antihyperlipidemic type drugs

Term

 

Know the differences and similarities of Hypercholesterolemia, Hyperglycemia, and Hyperlipidemia

Similarities:
All are ____ levels caused by specific ___ or diet.
Hypercholesterolemia and Hyperlipidemia are both cured by _____ drugs.

Differences
Hyperglycemia is cured by ___ drugs.

 

Definition
Similarities:
All are Elevated levels caused by specific Protein or diet.
Hypercholesterolemia and Hyperlipidemia are both cured by Antihyperlipidemic drugs.
 
Differences
Hyperglycemia is cured by Insulin drugs.
Term

Post Absorptive State or Fasting state

 

Insulin levels _____

Glucose levels _____

Glycogen levels ______

Glucagon levels _______

Definition

Insulin levels Low

Glucose levels Low

Glycogen levels Low

Glucagon levels High

Term

Starved State or Prolonged Fasting

 

Glucose Levels _____

Glycogen Levels ______

Insulin Levels ______

Glucagon Levels _____

Definition

Starved State or Prolonged Fasting

 

Insulin levels low

Glucose levels low

Glycogen levels low

Glucagon levels high

Term
In the Postabsorptive State or fasting state, which organ becomes the main exporter of glucose and ketone bodies?
Definition
Liver
Term
In the Fed State or absorptive state, which organ is the main transporter of glucose, amino acids, and Chylomicrons?
Definition
Intestine
Term
Chylomicrons carry which compound to the blood?
Definition
Triacylglycerides
Term

Postabsorptive State

 

Glucose Levels: _____

Insulin Levels: _____

Glycogen Levels: ______

Glucagon Levels: _______

Definition

Glucose Levels: Low

Insulin Levels: Low

Glycogen Levels: Low

Glucagon Levels: High

Term

Starved State or Prolonged Fasting State

 

Glucose Levels: ______

Glycogen Levels: _______

Insulin Levels: ________

Glucagon Levels: ________

Definition

Starved State or Prolonged Fasting State

 

Glucose Levels: Low

Glycogen Levels: Low

Insulin Levels: Low

Glucagon Levels: High

Term
Glycogen is broken down by this process in the liver during Postabsorptive State and transported to the blood
Definition
Glycogenolysis
Term
Triacylglycerols are broken down by this process ______ and this enzyme _____ to form ____ and ______.
Definition
Triacylglycerols are broken down by this process Lipidolysis and this enzyme pancreatic lipase to form Fatty Acids and 2-monoglycerols.
Term
In the Postaborptive State, the liver partially oxidizes fatty acids to form ________
Definition
Ketone Bodies
Term

Muscle and kidney obtain their energy from Ketone bodies by this process

 

Definition

Tricarboxylic acid cycle (TCA Cycle)



Muscle, kidney, and certain other tissues derive energy from completely oxidizing ketone bodies in the tricarboxylic acid (TCA) cycle. 

Term
Gluconeogenesis occurs in the _____ and produces glucose from ____, ____, and _____
Definition
Gluconeogenesis occurs in the Liver and produces glucose from Lactate, Glycerol, and amino Acids
Term
Ketone Bodies fuel these two parts of the body.
Definition
Muscle and Brain
Term
Ketone bodies are created in the liver by oxidizing _____
Definition
Fatty Acids
Term

T/F: All enzymes are proteins

 

T/F: All proteins are Enzymes

Definition

True: All enzymes are proteins

False: All proteins are enzymes

-all proteins are not enzymes

Term

During Starvation:

 

Glucose Levels _____

Fatty Acid Levels ______

Ketone Body Levels _______

Definition

During Starvation:

 

Glucose Levels Decrease

Fatty Acid Levels Increase

Ketone Body Levels Increase

Term
During starvation, muscle stops using this as fuel but continunes to burn fatty acids.
Definition
Ketone Bodies
Term

Differences in Fasting State and Starved State

 

1. Brain uses ____ as an energy source (Fasting State)

2. Muscle and Kidney use ___ as an energy source (Starvation state)

3. Muscle continues to use ____ for energy, but decreases its use of  _____.  (Starved State).

4. Brain uses ___ as an energy source (Starved State).

Definition

1. Brain uses glucose as an energy source (Fasting State)

2. Muscle and Kidney use Fatty Acids as an energy source (Starvation state)

3. Muscle continues to use Fatty Acids for energy, but decreases its use of  Ketone Bodies.  (Starved State).

4. Brain uses Ketone Bodies as an energy source (Starved State).

Term

Differences in Fasting State and Starving State

1._____ is the only way to produce glucose in the Starving State.

2. Glucose is still used in the _____ and partially in the _____ in the starving state.

3. 2 Process to produce glucose in the fasting state: ____ and _____

Definition

1. Gluconeogensis is the only way to produce glucose in the Starving State.

2. Glucose is still used in the RBC and partially in the brain in the starving state.

3. 2 Process to produce glucose in the fasting state: Glycogenolysis and Gluconeogenesis

Term

Creatinine released from the________ is proportional to muscle mass.

The amount of creatinine excreted can be used to determine amount of______ in the body. 

Definition

Creatinine Height Index measure the protein depletion from the body.

 

Creatinine released from the muscles is proportional to muscle mass.

The amount of creatinine excreted can be used to determine amount of muscle in the body. 

Term

There are a total of ___ L of water in the body.

____ L in the ICF

_____ L in the ECF

Definition

There are a total of 40 L of water in the body.

25 L in the ICF

15 L in the ECF

Term

The ECF has High concentrations of these 2 eletrolytes: ____ and ____

 

The ICF has High Concentrations of 1 electrolyte _____ and inorganic _____

Definition

The ECF has High concentrations of these 2 eletrolytes: Na+ and Cl-

 

The ICF has High Concentrations of 1 electrolyte K+  and inorganic Phosphate

Term

a.   _________: measure of concentration of solutes

                                 i.     Proportional to total concentration of all dissolved molecules.

 

Definition

a.    Osmolality: measure of concentration of solutes

                                 i.     Proportional to total concentration of all dissolved molecules.

 

Term

 

b.   ___________: quantity of a particular substance that can be dissolved in a particular solvent

Definition

 

b.    Solubility: quantity of a particular substance that can be dissolved in a particular solvent

Term

a.   _________ Bonds:

                                 i.     Strong electronegative atom with hydrogen

b.   _________ Interactions

                                 i.     Attraction: + with -             Repulsion: - with – or + with +

Definition

a.    Hydrogen Bonds:

                                 i.     Strong electronegative atom with hydrogen

b.    Ionic Interactions

                                 i.     Attraction: + with -             Repulsion: - with – or + with +

Term

a.   _________ Interactions

                                 i.     Nonpolar molecule with polar molecules

b.    __________ Reaction

                                 i.     Any 2 atoms in close proximity

Definition

a.    Hydrophobic Interactions

                                 i.     Nonpolar molecule with polar molecules

b.    Van der Waals Reaction

                                 i.     Any 2 atoms in close proximity

Term

a.    ∆G (free energy change) :

Favorable or Unfavorable

                                 i.     Negative = _______

                                ii.     Positive =______

Definition

a.    ∆G (free energy change) :


                                 i.     Negative = favorable reaction

                                ii.     Positive = unfavorable

Term

a.    ∆H (Enthalpy change)


                                 i.     Negative:    Exothermic                Bonds ________          Energy ______

                                ii.     Positive: Endothermic                 Bonds ________          Energy _________     

Definition

a.    ∆H (Enthalpy change)


                                 i.     Negative:    Exothermic                Bonds Broken          Energy Released

                                ii.     Positive: Endothermic                 Bonds formed          Energy Absorbed     

Term

a.    ∆S (_______Change)


                                 i.     Measure of _______ in a system

Positive or negative?

                                ii.    ______________ : more molecules, more randomness

__________ : less molecules, less randomness   

Definition

a.    ∆S (Entropy Change)


                                 i.     Measure of randomness in a system

                                ii.     Positive: more molecules, more randomness

Negative: less molecules, less randomness   

Term

1.    Know the importance of pH & why and how it is regulated

a.    A _______ pH wards off infections

b.    Body keeps a neutral pH by use of________.

Definition

a.    A neutral pH wards off infections

b.    Body keeps a neutral pH by use of buffers

Term

Know the Equation in water for

Keq =

K=

Kd =___

Definition

Keq = [H+][OH-] / [H2O]


K= [H+] [OH-]


Kd = Keq

Term

a.    _________ in the lungs is in equilibrium with the bicarbonate buffer in the blood passing through the lungs. Breathing can dissolve CO2 and the blood is in equilibrium with the CO2. But because carbonic acid is in equilibrium with CO2, less breathing can increase the levels of carbonic acid in the blood.

Buffers work best within a range of 1 pH unit either above or below the pKa of the buffer, where the pKa is the negative log of the Ka

Definition

a.    CO2 in the lungs is in equilibrium with the bicarbonate buffer in the blood passing through the lungs. Breathing can dissolve CO2 and the blood is in equilibrium with the CO2. But because carbonic acid is in equilibrium with CO2, less breathing can increase the levels of carbonic acid in the blood.

Buffers work best within a range of 1 pH unit either above or below the pKof the buffer, where the pKis the negative log of the Ka

Term
Enzyme that breaks down protein to amino acids
Definition
Proteases
Term
Enzyme that breaks down Fat or TG
Definition
pancreatic lipase
Term
4 enzymes that break down proteins are
Definition

4 enzymes that break down proteins are

 

pepsin, proteases, trypsin, chymotrypsin

Term
Triacylglycerides are mainly found in the _______ (organ)
Definition
Triacylglycerides are mainly found in the Intestines (organ)
Term
Triacylglycerides are packaged with proteins and cholesterols to form ________
Definition
Triacylglycerides are packaged with proteins and cholesterols to form Chylomicrons
Term
Chylomicrons, LDL, VLDL, and HDL are all found in the blood and are 4 forms of this type of protein
Definition

Chylomicrons, LDL, VLDL, and HDL are all found in the blood and are 4 forms of this type of protein

 

Lipoprotein

Term
This process breaks down Ketone bodies 
Definition

This process breaks down Ketone bodies 

 

TCA Cycle

Term
Gluconeogensis occurs in which organ?
Definition

Gluconeogensis occurs in which organ?

 

Liver

Term
Chylomicrons are made in this type of cells
Definition

Chylomicrons are made in this type of cells

 

Epithlial Cells

Term
In the Red Blood Cells, Glucose in converted to this. Also occurs during excercise in the muscle.
Definition

In the Red Blood Cells, Glucose in converted to this. Also occurs during excercise in the muscle.

 

Lactate

Term

Ketone Bodies are formed in this organ: _____

 

During Fasting and Starvations, they are the primary energy source in these 2 organs. ___ and ____

Definition

Ketone Bodies are formed in this organ

 

Liver


During Fasting and Starvations, they are the primary energy source in these 2 organs. Brain and Muscle

Term

Ketone Bodies can be made by partially oxidizing _____

 

They can also be made by amino acids because the liver can convert them to glucose or ketone bodies

Definition

Ketone Bodies can be made by partially oxidizing Fatty Acids

 

They can also be made by amino acids because the liver can convert them to glucose or ketone bodies.

Term
3 major Ketone bodies are 
Definition

3 major Ketone bodies are 

 

1  β-hydroxybutyrate 

2. acetoacetate

3. acetone     

Term
Which enzyme is used when CO2 and H2O are converted to carbonic Acid (H2COH3)?
Definition

Which enzyme is used when CO2 and H2O are converted to carbonic Acid (H2COH3)?


Carbonic Anhydrase

Term

Within the Red Blood Cell, what are the buffers?

____ and _____

Definition

Within the Red Blood Cell, what are the buffers?

____ and _____

 

Hemoglobin (Hb) and Phosphate (HPO4-

Term

Bicarbonate Buffer System

 

Decreased breathing results in:

______ dCO2 

_______ carbonic acid

__________ pH

_________ O2 in blood

Definition

Bicarbonate Buffer System

 

Decreased breating results in:

Increased      dCO2

decreased   carbonic acid

    decreased                   pH

decreased         O2 in blood

Term

RESPIRATORY ACIDOSIS


High or Low:         ___   PaCO& ____ pH

Definition

RESPIRATORY ACIDOSIS


High or Low:         High   PaCO2  & Low pH

*Too much CO2 creates too much Carbonic Acid

Term

RESPIRATORY ALKALOSIS  

  High or Low: ___ PaCO2  _____pH 

Definition

 

RESPIRATORY ALKALOSIS  

  High or Low: Low PaCO2     High pH 

 

Term

METABOLIC ACIDOSIS    


High or Low

 

____ HCO3-  & _____ pH 

Definition

METABOLIC ACIDOSIS    


High or Low

 

Low HCO3-  & Low pH 

*metabolic are proportional to pH and Bicarbonate

Term

METABOLIC ALKALOSIS    


 High or Low


____  HCO3-  & ____  pH

Definition

METABOLIC ALKALOSIS  

  

High HCO3-   &   High pH

Term

Which one is an omega-3 and omega-6 fatty acid?

 

Linoleic _____

Linolenic ______

Definition

Which one is an omega-3 and omega-6 fatty acid?

 

Linoleic   Omega 3

Linolenic  Omega 6

Term

Triacylglycerides are broken down pancreatic lipase by this process

 

_________

Definition

Triacylglycerides are broken down pancreatic lipase by this process

 

Lipidolysis

Term
Gluconeogenesis Occurs in the ______ and is the only way for your body to produce glucose in the starvation state.
Definition
Gluconeogenesis Occurs in the Liver and is the only way for your body to produce glucose in the starvation state.
Term
During the starvation state, glucose is still being used main in the ______ and partially in the brain.
Definition
During the starvation state, glucose is still being used main in the Red Blood Cells and partially in the brain.
Term
Glucose contains an aldehyde which makes it a ______
Definition
Glucose contains an aldehyde which makes it a Aldohexose
Term
Carboxylic Acid + Alcohol = _______
Definition

Carboxylic Acid + Alcohol = Ester

 

Term
Carboxylic Acid + Sulfhydryl = _______
Definition

Carboxylic Acid + Sulfhydryl = Thioester


Term
Phosphoric Acid + Alcohol = __________
Definition
Phosphoric Acid + Alcohol = Phosphoester
Term
The product that leaves when an acid and alcohol interact is  ________
Definition
The product that leaves when an acid and alcohol interact is  Water
Term
Carboxylic Acid + Amine = _______
Definition
Carboxylic Acid + Amine = Amide
Term

Phosphoric Acid + Phosphoric Acid = _______

 

What by product results from this interaction?

Definition

Phosphoric Acid + Phosphoric Acid = Anhydride

 

What by product results from this interaction?

 

Water

Term

Difference between glucose and fructose is the location of the ______ group

 

This makes Fructose a ______

and glucose a aldohexose

Definition

Difference between glucose and fructose is the location of the Carbonyl group

 

This makes Fructose a ketohexose

and glucose a aldohexose

Term

Bottom or Top

 

alpha linkage occurs with the hydroxyl group on the _____ 

Definition

Bottom or Top

 

alpha linkage occurs with the hydroxyl group on the Bottom (below the H)

Term

Bottom or top

 

Beta-linkage occurs with the hydroxyl group on the ______

Definition

Bottom or top

 

Beta-linkage occurs with the hydroxyl group on the Top

Term

What is the term that describes: ________


Flipping the OH from the enantionmeric center

 

i)      Change in the optical rotation that occurs in an equilibrium between two epimers (differ in 1 stereocenter).

Definition

What is the term that describes: Mutarotation


Flipping the OH from the enantionmeric center

 

i)      Change in the optical rotation that occurs in an equilibrium between two epimers (differ in 1 stereocenter).

Term

What is the Term?

a)   ______________

i)      Same chemical formula

ii)    Different positions of functional groups

Definition

 

What is the Term?

a)   Stereoisomer

i)      Same chemical formula

ii)    Different positions of functional groups

 

Term

What is the Term?

a)    __________________

i)      one of two stereoisomers

ii)    mirror images of each other

iii)   non-superposable

  

Definition

 

What is the Term?

Enantiomer

i)      one of two stereoisomers

ii)    mirror images of each other

iii)   non-superposable

 

Term

a)    Oxidized Sugar:

i)      Oxidized at the _______  group to form an acid

Which group?

Definition

a)    Oxidized Sugar:

i)      Oxidized at the aldehyde group to form an acid

Term

i)      If _______ group is reduced, changed to a deoxy sugar and replaced with( -H)

Definition

i)      If hydroxyl group is reduced, changed to a deoxy sugar and replaced with( -H)

 

Term

1)    Also know the difference between pyranose and furanose.

D-glucose has a ______ group

D-fructose has a ______ group

D-glucose forms glucopyranose which has a ____ membered ring

D-fructose forms fructofuranose which has a ____ membered ring

Definition

1)    Also know the difference between pyranose and furanose.

D-glucose has a Aldehyde group

D-fructose has a Ketone group

D-glucose forms glucopyranose which has a 6 membered ring

D-fructose forms fructofuranose which has a 5 membered ring

Term

1)    Identify each class of lipids, list their functions and explain their relationships with specific diseases

a)    Fatty acids:

Unsaturated has ______ bonds

Cis is (good or bad)

Trans (good or bad)

Saturated are also called _____ acids

Definition

1)    Identify each class of lipids, list their functions and explain their relationships with specific diseases

a)    Fatty acids:

Unsaturated has Double bonds

Cis is (good or bad)

Trans (good or bad)

Saturated are also called stearic acids

Term

Linoleic and Linolenic are examples of _____ Fatty Acids that are in the (cis or trans) form.

 

Linolenic is also called omega-(3,6,9) fatty acid

 

Linoleic is also called omega-(3,6,9) fatty acid

Definition

Linoleic and Linolenic are examples of unsaturated Fatty Acids that are in the (cis or trans) form.

 

Linolenic is also called omega-(3,6,9) fatty acid

 

Linoleic is also called omega-(3,6,9) fatty acid

Term

1)    Identify each class of lipids, list their functions and explain their relationships with specific diseases

Fatty Acid and Glycerol can be formed with esterification to make _______ 

 

_______ can also be oxidized to CO2 and H2O

Definition

 

1)    Identify each class of lipids, list their functions and explain their relationships with specific diseases

 

Fatty Acid and Glycerol can be formed with esterification to make Triacylglycerols 

 

Triacylglycerols can also be oxidized to CO2 and H2O

Term

1)    Identify each class of lipids, list their functions and explain their relationships with specific diseases

 

Phospholipids are a major components of the _____ (this part of call)

They are cleaved by ______

and a Lung Surfactant

Definition

Phospholipids are a major components of the membrane

They are cleaved by phospholipases

and a Lung Surfactant

Term

1)    Identify each class of lipids, list their functions and explain their relationships with specific diseases

Sphingolipids are derivatives of ____

Sphingomyelin
Galactocerebroside
Ganglioside
White matter of CNS
Sphingolipidoses
Tay-Sachs
Gauchers

Definition

1)    Identify each class of lipids, list their functions and explain their relationships with specific diseases

Sphingolipids are derivatives of ceramide

 

Sphingomyelin
Galactocerebroside
Ganglioside
White matter of CNS
Sphingolipidoses
Tay-Sachs
Term

1)    Identify each class of lipids, list their functions and explain their relationships with specific diseases

______ are forms of cholesterol 

precursers for hormones, Vitamin D, and Bile Acids

Definition

Steroids are forms of cholesterol 

precursers for hormones, Vitamin D, and Bile Acids

Term

1)    Identify each class of lipids, list their functions and explain their relationships with specific diseases

______ are short-term signaling molecules

Prostaglandins (PGs)

Thromboxane A2 (TXA2)

Leukotrienes (LTs)

Definition

Eicosanoids are short-term signaling molecules

Prostaglandins (PGs)

Thromboxane A2 (TXA2)

Leukotrienes (LTs)

Term

Chapter 5

______ is a compound that has a Hydrogen that can shift places resulting in double to single bonds or opposite.

Considered same compound different structure.

 

One form is more reactive than the other

 

Example: uric acid, urate, gout

Definition

Chapter 5

Tautomer is a compound that has a Hydrogen that can shift places resulting in double to single bonds or opposite.

Considered same compound different structure.

 

One form is more reactive than the other

 

Example: uric acid, urate, gout

Term

Chapter 5

 

____ is a compound that has a single electron

 

______ exist independently within a solution

Definition

Chapter 5

 

Radical is a compound that has a single electron

 

Free Radical exist independently within a solution

Term

Chapter 5

 

______ are radicals within a cell that are the source for desctruction. 

Very toxic, reactive, and potent.

Ex: Nitrogen Oxide radical

Definition

Chapter 5

 

Superoxides are radicals within a cell that are the source for desctruction. 

Very toxic, reactive, and potent.

Ex: Nitrogen Oxide radical

Term

Chapter 5

 

Purines + Pyrimidines + _______ are all nitrogenous bases

Definition

Chapter 5

 

Purines + Pyrimidines + pyridines are all nitrogenous bases

Term

       Clinical correlations: understand how the chlorinated aromatic hydrocarbon environmental toxins behave in the body

____ and ____ are chlorinated aromatic hydrocarbon environmental toxins.

___ were used as herbicides in the US.

___ are formed as by product during the production of other chlorinated cmpounds and herbicides

Definition

       Clinical correlations: understand how the chlorinated aromatic hydrocarbon environmental toxins behave in the body

DDTs and CDDs are chlorinated aromatic hydrocarbon environmental toxins.

DDT were used as herbicides in the US.

CDDs are formed as by product during the production of other chlorinated cmpounds and herbicides

Term

Two endocrine hormones regulate fuel storage and retrieval

_____ and _____

Definition

Two endocrine hormones regulate fuel storage and retrieval

glucagon and insulin

Term

Chapter 2

Major carbohydrate in blood is _____ and its levels regulate the release of insulin and glucagon

Definition
Major carbohydrate in blood is glucose and its levels regulate the release of insulin and glucagon
Term

Chapter 2

Glucose can be stored in two forms in the fed state:

_____ and ____

Definition

Chapter 2

Glucose can be stored in two forms in the fed state:

Triacylglycerol and Glycogen

Term

Chapter 2

 

Insulin stimulates the uptake of glucose in _____ and _____

Definition
Insulin stimulates the uptake of glucose in adipose tissue and muscle
Term
Triacylglcerol obtains from the diet is released in the blood in the form of ______
Definition
Triacylglcerol obtains from the diet is released in the blood in the form of Chylomicrons
Term

Chapter 2

Triacylglycerols can be made from glucose in the _____ and released as _____

 

_______ is the storage stie for triacylglycerols

Definition

Triacylglycerols can be made from glucose in the Liver and released as VLDL.

 

Adipose Tissue is the storage stie for triacylglycerols

Term

Chapter 2

___ and ____ use glucose as a primary energy source under normal conditions

Definition
Brain and Red Blood Cells use glucose as a primary energy source under normal conditions
Term
Amino Acids in the diet are used to form _____ and nitrogen-containing molecules and an energy source.
Definition
Amino Acids in the diet are used to form Protein and nitrogen-containing molecules and an energy source.
Term
After a high-carb meal, your liver and skeletal muscles use ____ as their major fuel
Definition
After a high-carb meal, your liver and skeletal muscles use glucose as their major fuel
Term
During fasting, ______ is released from the pancrease.
Definition
During fasting, Glucoagon is released from the pancrease.
Term
In the fasting state, the glucagon released from the pancreas signals to the _____ to release more glucose in to circulation.
Definition
In the fasting state, the glucagon released from the pancreas signals to the Liver to release more glucose in to circulation.
Term
Ketone bodies are made from the _____ .
Definition
Ketone bodies are made from the Liver .
Term
Glucagon also signals the fat cells to degrade triacylglycerol into fatty acids and glycerol for ______.
Definition
Glucagon also signals the fat cells to degrade triacylglycerol into fatty acids and glycerol for gluconeogenesis.
Term
The three substrates for gluconeogenesis are lactate, _____, and glycerol.
Definition
The three substrates for gluconeogenesis are lactate, Amino Acids, and glycerol.
Term
In starvation, the brain adapt to using ketone bodies for energy. This results in a reduced rate of muscle protein degradation to provide more precursors for this process ______. 
Definition
In starvation, the brain adapt to using ketone bodies for energy. This results in a reduced rate of muscle protein degradation to provide more precursors for this process Gluconeogenesis
Term
After 24 hours of fasting, _______ occuring in the liver,will be the major source of glucose.
Definition
After 24 hours of fasting, Gluconeogenesis occuring in the liver,will be the major source of glucose.
Term
Patient stops taking insulin for 5 days and results in elevated glucose levels and ketone bodies. The ketone bodies are elevated by of the ______. 
Definition
Patient stops taking insulin for 5 days and results in elevated glucose levels and ketone bodies. The ketone bodies are elevated by of the glucose
Term
You can increase the carbonic acid concetration in your body or lower your pH by ______ breathing.
Definition
You can increase the carbonic acid concetration in your body or lower your pH by reducing breathing.
Term

Bicarbonate Buffer system in the body occurs in the ECF or ICF?


Definition

Bicarbonate Buffer system in the body occurs in the ECF or ICF?

 
ECF
Term
Linoleic and Linolenic are from _____ oils (walnut)
Definition
Linoleic and Linolenic are from Plant oils (walnut)
Term

EPA (eicosapentaenoic acid) &
DHA (docosahexaenoic acid) 
are from_____ oil

Definition
EPA (eicosapentaenoic acid) &
DHA (docosahexaenoic acid) 
are from Fish oil
Term

Polyunsaturated
Help maintain _____ of cellular membranes
Precursors for arachidonic acid (_____acid) from which the eicosanoids are derived
Prevent platelet aggregation 

Definition

Polyunsaturated
Help maintain fluidity of cellular membranes
Precursors for arachidonic acid (linoleic acid) from which the eicosanoids are derived
Prevent platelet aggregation 

Term

Essential Fatty Acids
Deficiency: dermatitis, ___  ___ ___, hair loss

Definition
Essential Fatty Acids
Deficiency: dermatitis, slow wound healing, hair loss
Term

Monosaccharides

Glucose: ___ sugar, energy for most cells

 

 Galactose: converted to glucose and _____

 

Fructose: _____ sugar, converted to glucose and metabolized

Definition

 

Monosaccharides

Glucose: blood sugar, energy for most cells

 

 Lactose: converted to glucose and metabolized

 

Fructose: Fruit sugar, converted to glucose and metabolized

 

Term

Disaccharides

 

Sucrose: ___ sugar, digested to glucose and ____

 

Lactose: ___ sugar, digested to glucose and ___ ; important in ____ nutrition

 

Maltose: ___ sugar, product of ____ digestion, digested to glucose and _____

Definition

Disaccharides

 

Sucrose: Cane sugar, digested to glucose and Fructose

 

Lactose: Milk sugar, digested to glucose and Galactose ; important in infant nutrition

 

Maltose: Malt sugar, product of starch digestion, digested to glucose and glucose

Term

Polysaccharides

 

_____ : structural polysaccharide of plants

 

_____: Energy storage in plant cells

 

______: energy storage in animal cells; (liver, muscle, brain, uterus, vagina)

Definition

Polysaccharides

 

Cellulose : structural polysaccharide of plants

 

Starch: Energy storage in plant cells

 

Glycogen: energy storage in animal cells; (liver, muscle, brain, uterus, vagina)

Term
3 Conjugated Carbohydrates are ____, ____, and ___.
Definition
3 Conjugated Carbohydrates are Glycolipid, glycoprotein, and Proteoglycan.
Term

Conjugated Carbohydrates

 

_____ and _____  are components of the cell surface coat .

 

____ function is cell adhesion; lubrication; supportive filler of some tissues and organs

 

Definition

Conjugated Carbohydrates

 

Glycoprotein and Glycolipid are components of the cell surface coat .

 

Proteoglycan function is cell adhesion; lubrication; supportive filler of some tissues and organs

 
Term
Body stores the most fuel in the form of ______ > Protein > Glycogen in your ____ and ____
Definition
Body stores the most fuel in the form of Triglycerides > Protein > Glycogen in your Muscle and Liver.
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