Term
| Fibril forming collagen is found in which type? |
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Definition
| Type 1, 2, and 3 collagen forms fibril forming collagen. |
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Term
| Skin, bone, tendon, blood vessels, and cornea compose which type of collagen? |
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Definition
| Type 1 collagen forms skin, bone, tendon, bv, and cornea. |
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Term
| Cartilage, intervertebral disk, and vitreous body forms? |
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Definition
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Term
| The skin of the fetus is composed of what collagen type? |
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Definition
| Type 3 collagen forms fetal skin. |
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Term
| The skin of the fetus is composed of what collagen type? |
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Definition
| Type 3 collagen forms fetal skin. |
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Term
| What collagen compose basement membrane? |
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Definition
| Basement membranes are composed of type 4 collagens. |
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Term
| During pro-alpha chain assembly, ________ and interchain _________ bonds form at N-terminal propetide extension. |
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Definition
| Intrachain, false the disulfide bond forms at C-terminal propeptide extension. |
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Term
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Definition
| False, collagen genes are spread all over the genome. |
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Term
| The structure of collagen is composed of amino acids _______, _______, _______. |
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Definition
| Collagen is composed of a triple helical amino acid structure intertwined by hydroxyproline, hydroxylysine, and Glycine. |
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Term
| What two genes are transcribed in the 1st step of collagen synthesis? |
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Definition
| Pro-alpha 1 and pro-alpha 2 are the 1st genes transcribed into mRNA. |
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Term
Which Hydoxylated amino acid residues are glycosylated with glucose and galactose?
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Definition
| Hydroxylysine is the amino acid that is glycosylated w/ glucose & galactose. |
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Term
The signal sequence of prepro-alpha-peptide mRNA is removed in the:
a-Nucleus
b-Cytoplasm
c-Golgi aparatus
d-Endoplasmic Reticulum
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Definition
| The Endoplasmic Reticulum is the site of signal seq. removal of prepro-alpha-peptide. |
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Term
| True/False procollagen is cleaved before being secreted from ER? |
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Definition
| False, procollagen is 1st secreted from Golgi vacuole, and 2nd N&C terminal propeptides are cleaved in the extracellular matrix. |
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Term
| In linear polymer staggered stacking of collagen fibrils, how is staining produced? |
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Definition
| Only in regions with gaps are where heavy staining seen. |
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Term
| Vitamin C and Fe+2 is required by which process in collagen synthesis? |
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Definition
| Prolyl hydroxylase requires Fe+2 and Ascorbic acid (Vit. C) as cofactors to hydroxylate proline. |
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Term
Hydroxylation of proline requires the cofactors:
a-alpha Ketogluterate
b-Oxygen
c-Ascorbate
d-Fe+2
e-all of the above
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Definition
| Hydroxylation by prolyl hydroxylase of proline requires O2, alpha ketogluterate, ascorbate, and Fe+2. |
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Term
| T/F lysyl hydroxylase and prolyl hydroxylase requires the same cofactors? |
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Definition
| True, they req. Fe, and Vit. C. |
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Term
Tell me which is the correct steps of collagen synthesis?
a-, Pro-alpha chain, Hydroxyprolyl residue, Prolyl residue
b-Prolyl residue, Pro-alpha chain, Hydroxylation step
c-Prolyl residue, Hydroxylation step, Pro-alpha chain
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Definition
| c-Prolyl residue,Hydroxylation step, Pro-alpha chain. |
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Term
| Scurvy is considered a mild disease because? |
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Definition
| It is mal-nutritionally based and mediated by Ascorbic acid rich foods like citrus foodstuffs. |
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Term
| OI is a result of what genetic change? |
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Definition
| OI results from collagen gene substitutions in COL1A1 or COL1A2 resulting in substitution of Gly to another. |
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Term
| What is the microscopic consequence of genetic mutation of COL1A2 & COL1A1? |
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Definition
| OI result due to incorrect folding of collagen's triple helix. |
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Term
| Ehlers-Danlos Syndrome is cause by and clinically presents? |
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Definition
| EDS is a genetic collagen disorder, it is typified by stretchy skin and joint hypermobility. |
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Term
| T/F elastin is stretchy b/c it has more hydroxylation of it proline and lysine components? |
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Definition
| False it has little hydroxyproline and no hydroxylysine. |
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Term
Mutation in ______ is responsible for Marfan Syndrome:
a-Lysine
b-collagen
c-elastin
d-fibrillin
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Definition
| Fibrillin, is the causitive source of Marfan Syndrome when FBN1 is mutated. |
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Term
| A deletion of chromosome 15 would affect which connective tissue? |
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Definition
| Chromesome 15 contains FBN1 which codes for fibrillin, which will vicariously affect elastin. |
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Term
Desmosine cross-link is seen seen in which connective tissue type?
a-collagen
b-elastin
c-fibrillin
d-proline
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Definition
| Desmosine cross-linking is classical of elastin's elastic properties, this is produced by oxidative deamination by lysyl oxidase. |
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