Term
| Heparin affects blood clot formation towards the _____ of the blood clotting pathway |
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Definition
end
(including both intrinsic and extrinsic pathways) |
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Term
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Definition
| has anti-thrombin activity and binds to kallikrein (a protein affecting localized inflammation) |
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Term
| The differences between OSCS and heparin are |
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Definition
| caused by the constituents attached to the ring, not the ring itself |
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Term
| This type of inhibitor increases apparent KM, but does not affect Vmax. |
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Definition
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Term
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Definition
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Term
| Distribution of lipids in the cell membrane is |
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Definition
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Term
| Carbs drag _____ water than lipids |
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Definition
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Term
| Phospholipase only interacts with the |
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Definition
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Term
| What method of enzyme catalysis best describes how isocitrate dehydrogenase catalyzes the protonation of NADP+ to form NADPH? |
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Definition
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Term
| Which of the following types of inhibition impact the Vmax of an enzyme? |
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Definition
noncompetitive
uncompetitive |
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Term
| The effects of which type of enzyme inhibition are completely swamped by the presence of high concentrations of substrate? |
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Definition
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Term
| Of the following five, which function as receptor-based senses? |
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Definition
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Term
| Upon reception of a signal, which molecules move into the cell and which move out of the cell? |
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Definition
| K moves out, Na and Cl move in |
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Term
| What function does the aspartate hold in the serine/cysteine protease mechanism? |
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Definition
| Its hydrogen-bonds help to make histidine more basic. |
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Term
| True or False: A high Km indicates that the binding is weak, low Km means that the binding is strong. |
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Definition
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Term
| The OmpF porin is _______ cation selective |
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Definition
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Term
| Coupled reactions in glycolysis |
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Definition
| Glyceraldehyde-3-phosphate Dehydrogenase and Phosphoglycerate Kinase |
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Term
| Which sugar enters earliest |
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Definition
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Term
| Which enzyme of glycolysis would be affected by the decrease in cyclic AMP concentration |
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Definition
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Term
| Which enzymes regulate flux through the pathway? |
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Definition
Hexokinase
Phosphofructokinase
Pyruvate kinase |
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Term
| Iodoacetate --> reacts with cysteine side chain inhibits |
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Definition
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Term
| DEPC --> reacts with histidine side chains inhibits |
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Definition
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Term
| AMPPCP --> a non-hydrolyzable analog of ATP. There is a carbon in place of the oxygen between the beta and gamma phosphates inhibits |
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Definition
Hexokinase
Phosphofructokinase |
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Term
| Lower glycolysis normally produces__ ATP molecules for every glucose |
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Definition
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Term
| Why is it advantageous to have 3 major points of regulation within glycolysis rather than just having the first step be the primary regulatory step as in other pathways? |
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Definition
| Multi-tiered regulation allows for shifting of metabolites in and out of the glycolytic pathway as needed |
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Term
| Glucagon alters glycolysis flux by |
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Definition
| increasing Phosphofructokinase 1 activity |
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Term
| In the presence of high levels of glucagon, what kinetic constant changes for PFK |
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Definition
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Term
| Fructose in the liver can be useful for what pathways |
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Definition
B.) synthesis of Lipid molecules
C.) production of GAP and DHAP for Glycolysis |
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