Term
| what are prostaglandins related to |
|
Definition
| leukotrines and thromboxanes |
|
|
Term
|
Definition
| prostaglandins, leukortines, thromboxanes |
|
|
Term
| how are prostaglandins different from hormones |
|
Definition
| made in cells, act locally, short half life, small concentration needed |
|
|
Term
| what is thromboxane made by |
|
Definition
|
|
Term
| what is the function of thromboxane |
|
Definition
| aggregate platlets, vasoconstriction |
|
|
Term
|
Definition
|
|
Term
| what is the function of prostacyclin |
|
Definition
| platlet dispersion, vasodilation |
|
|
Term
| what is the most common precursor for prostaglandins |
|
Definition
|
|
Term
| what is needed to make arachidonic acid |
|
Definition
|
|
Term
| where is arachidonic acid located |
|
Definition
| esterified to phospholipids in membranes |
|
|
Term
| how is arachidonic acid released |
|
Definition
|
|
Term
| what does lipoxygenase do |
|
Definition
|
|
Term
| what are leukotrines involved in |
|
Definition
|
|
Term
| what does cyclooyxgenase do |
|
Definition
| make prostacyclin and thromboxane |
|
|
Term
|
Definition
| stop COX1 and COX2 which are involved with cyclooxygenase |
|
|
Term
| what are the tpes of anti-inflammatory drugs |
|
Definition
| steroids (glucocorticoids) and NSAIDS |
|
|
Term
| what type of anti-inflammatory is aspein |
|
Definition
|
|
Term
|
Definition
| stop lipoxygenase and stop COX1 and COX2 |
|
|
Term
|
Definition
| stop arachidonic acid, down regulate COX2 |
|
|
Term
| what do antiinflammatory drugs do in general |
|
Definition
| turn on gene to make inhibitor |
|
|
Term
| what is a negative result of asprin blocking the COX pathway |
|
Definition
| leukotrienes build up and cause asthma |
|
|
Term
| how does asprin inhibit cyclooxygenase |
|
Definition
| irreversible / suicide. acetlyates it |
|
|
Term
| why does asprin block clotting so well |
|
Definition
| because platlets cant make cyclooxygenase because they dont have genes so when it limits thromboxane it reduces it for their clotting for their life |
|
|
Term
| what do vascular endothelial cells make |
|
Definition
|
|
Term
| what does asprin do to vascular endothelial cells |
|
Definition
| hinders prostacyclin release some but not much because the cells ahve nuclei and can make more enzyme |
|
|
Term
| why would someone want to take daily asprin |
|
Definition
| because plaque can grab blood clots and make athlerosclerosis worse |
|
|
Term
| what happens when prostaglandin binds to platlets |
|
Definition
| activating cAMP inhibiting release of granules with platlet aggregating agents |
|
|
Term
| what are examples of platlet aggregating angents |
|
Definition
|
|
Term
| what happens when they is injury in the endothelium |
|
Definition
| it releases thromboxane which activates PIP2 which activates IP3, DAG or Ca, and releases granules with aggregating agents |
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