Term
| what are the functions of nucleotides |
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Definition
| sytructural component of DNA/RNA, carriers of actiated intermediates, structural components of coenzymes, secondary messengers, energy currency, regulator |
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|
Term
| what are the components of nucleotide structure |
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Definition
| nitrogenous bases, purine or primiding, ribose or deoxyribose |
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|
Term
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Definition
| nitrogenous base and sugar |
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Term
|
Definition
| nucleoside and 1,3-phosphate |
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|
Term
| what type of nucleotide isnt salvaged |
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Definition
|
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Term
| what is the first thing that happens to a nitrogenous base in nitrogen metabolism |
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Definition
| it gets rid of P and sugar to make hypoxanthine or guanine |
|
|
Term
| what are the options for hypozanthine or guanine |
|
Definition
| go back into purine nucleotide synthesis with the salvage path or turn into uric acid with xanthine oxidase in teh excretion path |
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|
Term
| what does an adenosine deaminase deficiency cause |
|
Definition
| secere combine immunodeficiency disease |
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|
Term
| what are teh symptoms of adenosine deaminase deficiency |
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Definition
|
|
Term
| what is the intreatment for adenosine deaminase deficiency |
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Definition
| bone marrow transplant, enzyme replacement therapy |
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|
Term
| what is another name for gout |
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Definition
|
|
Term
|
Definition
| elevated or decreased uric acid that crystalizes in joints leading to inflammation and arthritis |
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Term
|
Definition
| inhibit xanthine oxidase helping over production |
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|
Term
| what is an alternative cause for gout |
|
Definition
| high cell turn over in cancer patients |
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|
Term
| where does ribose-5-p come from for nucleotide synthesis |
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Definition
|
|
Term
| what are the common intermediates for nucleotide synthesis for both purines and primidines |
|
Definition
|
|
Term
| what turns ribose-5-P into PRPP |
|
Definition
|
|
Term
| what activates PRPP synthase |
|
Definition
|
|
Term
| what inactivates PRPP synthase |
|
Definition
|
|
Term
| what is the rate limiting step of purine synthesis |
|
Definition
| PRPP into 5-phosphorbiusylamine using PRPP amino transferase |
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|
Term
| what does 6-mercaptopurine do |
|
Definition
| anti tumor drug, intimidates purines inhibiting PRp amino transferase |
|
|
Term
| what happens after PRPP amino transferase in purine synthesis |
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Definition
| glycine, asparatate, glutamine, THF are added to make the ribonucleotide |
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Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| what does methotrexate do |
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Definition
| antiimmune drug that stop sihydrofolate reductase so it cant make THF and so purine synthesis cant happen |
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|
Term
| how can a deoxyribonucleotide be made |
|
Definition
| use ribonucleotide reductase on a ribonucleotide |
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|
Term
|
Definition
| anti immune drug, treats sickle cell, increases fHb, stops ribonucleotide reductase |
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|
Term
| what is the rate limiting enzyme in primidine synthesis |
|
Definition
| carbamoyl-p synthetase II (CPS II) |
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| turns PRPP into carbamoyl phosphate |
|
|
Term
| what happens to carbamoyl phosphate to make ribonucleotides |
|
Definition
| add glutamine, asparatate, and PRPP |
|
|
Term
| what converts dUMP to dTMP |
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Definition
|
|
Term
| what inhibits thymidylate synthase |
|
Definition
| antitumor drug 5-fluroracil |
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|
Term
| what drugs affect DNA production |
|
Definition
| hydroxyurea and 5-fluroracil |
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|
Term
| what cofactor does thymidylate synthase need |
|
Definition
|
|
Term
| what does trimethporim do |
|
Definition
| antibiotic that stops prokaryotic dihydroxyfolate reductase |
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|
Term
| do humans need folate in their diet |
|
Definition
|
|
Term
| do prokaryotes need folate in their diet |
|
Definition
|
|
Term
|
Definition
| antibiotic that targets enzymes in bacteria that make folic a in prokaryotes |
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|
Term
| what is the inheritance of lesch nyhan syndrome |
|
Definition
|
|
Term
| what is broken in lesch nyhan syndrome |
|
Definition
| purine salvage pathway: hypoxyathine-guanine phosphoribosyltransferase. purine deficit |
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|
Term
| what does a purine deficit cause |
|
Definition
| degradation products into the pathway making uring A resulting in extreme hyperuricemia |
|
|
Term
| what are the symptoms of lesch nyhan syndrome |
|
Definition
| mental retardation, self destructuve behavior, severe gout |
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