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Biochem Exam 3
Biochem Exam 3
31
Biology
Graduate
04/27/2010

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Term
The bond linking a fatty acid to conenzyme A is...
Definition
a thioester
Term
The carrier molecule which transports fatty acids through the inner mitochondrial membrane is...
Definition
carnitine
Term
In beta-oxidation of fatty acids, initiation occurs at the methyl end of the fatty acid...TRUE/FALSE
Definition
FALSE
Term
At the beginning of catabolism, the activated fatty acid has a ____ bond.
Definition
thioester
Term
Where in the cell does beta-oxidation occur?
Definition
mitochondrial matrix
Term
A special carrier is needed to get fatty acids into the mitochondria, since an acyl-CoA cannot cross the outer mitochondrial membrane...TRUE/FALSE
Definition
FALSE
Term
What best describes carnitine?
Definition
It transports fatty acids across the inner mitochondrial membrane.
Term
The first three reactions of the beta-oxidation cycle of fatty acids produce...
Definition
one each of NADH and FADH2
Term
What is not a product of the activation of fatty acids?
Definition
ADP
Term
Fatty acid catabolism is called beta-oxidation, since the second (beta) carbon from the carboxyl group is the site of oxidation (cleavage). TRUE/FALSE
Definition
TRUE
Term
What is the order of reactions involved in beta-oxidation of fatty acids?
Definition
1)Formation of a C-C double bond
2)Hydration of a double bond
3)Oxidation of an alcohol
4)Cleavage of acetyl-CoA from the fatty acid
1)
Term
Acetyl-CoA requires 8 cycles of beta-oxidation to produce palmitic acid, with 16 carbons...TRUE/FALSE
Definition
FALSE
Term
The processing of one molecule of stearic acid (18 carbons) by beta-oxidation requires...
Definition
8 cycles of beta-oxidation and produces 9 molecules of acetyl-CoA
Term
How many NAD+ are reduced in the degradation of palmitoyl-CoA to form 8 molecules of acetyl-CoA?
Definition
7
Term
What vitamin/cofactor is used in fatty acid biosynthesis?
Definition
biotin
Term
Lipids yield more ATP than sugars because?
Definition
They have more carbon atoms than sugars, thus producing more acetyl-CoA
Term
As a result of the beta-oxidation of fats, compared to oxidation of sugars, fatty acids produce more metabolic water during oxidative phosphorylation. TRUE/FALSE
Definition
TRUE
Term
Fatty acids are advantageous forms of energy storage because...
Definition
they contain more carbons than carbohydrates, their hydrophobicity allows close packing and do not require water for transport, and contain more energy than sugars
Term
In the catabolism of fatty acids with uneven numbers of carbon atoms, intermediates are converted to ___ before the final product of ___.
Definition
propionyl-CoA; succinyl-CoA
Term
The beta-oxidation of fatty acids with an odd number of carbons requires conversion to pyruvate before entering the citric acid cycle. TRUE/FALSE
Definition
FALSE
Term
The cis double bonds of fatty acids react well with the EH enzyme. TRUE/FALSE
Definition
FALSE
Term
The b-oxidation of unsaturated fatty acids requires additional enzymes to isomerize the double bonds. TRUE/FALSE
Definition
TRUE
Term
The unsaturated fatty acids that are intermediates in the beta-oxidation cycle must have what orientation around the double bond?
Definition
trans
Term
Isomerization of the double bonds of polyunsaturated fatty acids involves both: (i) a cis-trans isomerization; and (ii) changing the position of the double bonds. TRUE/FALSE
Definition
TRUE
Term
Where in the cell does fatty acid synthesis occur?
Definition
Cytoplasm
Term
Reduction reactions during fatty acid synthesis utilize...
Definition
NADPH
Term
Reduction reactions during fatty acid synthesis utilize...
Definition
NADPH
Term
NADPH is required for anabolism of fatty acids and NOT for catabolism. TRUE/FALSE
Definition
TRUE
Term
Synthesis of fatty acids is simply the reverse of the beta-oxidation cycle. TRUE/FALSE
Definition
FALSE
Term
During fatty acid synthesis, the growing fatty acid is always bound to a protein. TRUE/FALSE
Definition
TRUE
Term
The committed step (Rate-limiting) in cholesterol biosynthesis is catalyzed by...
Definition
HMG-CoA reductase
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