Shared Flashcard Set

Details

Biochem Exam 3
Exam 3 Material
22
Biochemistry
Graduate
11/14/2010

Additional Biochemistry Flashcards

 


 

Cards

Term
What are the two main amino sugars that make up glucosaminoglycans?
Definition

 

  • N-Acetylglucosamine
  • N-Acetylgalactosamine

 

Term
What are the two main uronic acid components that make up GAG's?
Definition

Iduronate 

 

Glucuronate

Term
Do GAG's have a negative or a positive charge?

From this, what do they attract?
Definition

 

Negative

 

Attract water and Sodium

Term
Progeria is caused by a lack of what GAG?
Definition
Dermatan Sulfate
Term
What disaccharide makes up hylauron?
Definition

 

 

Glucouronate and N-Acetylglucosamine

Term
What GAG is used as a space filler in early embryos and resists compression in adults?
Definition

 

 

Hyaluronan

Term
True or False: Hyaluronan is not bound to a protein?
Definition

TRUE.

 

Hyaluronan is a "stand alone" GAG. 

Term
What is the most common GAG and what can it bind to?
Definition
Chondroitin Sulfate, binds to collagen
Term

What end of Chondroitin Sulfate is epimerized to form Dermatan Sulfate?

 

It goes from ____ to ____

Definition

The Carboxyl end

 

goes from Glucouronate to Iduronate

Term
What GAG has the most Sulfate?
Definition
Heparin
Term
Where can Sulfates be added on to GAGs?
Definition

N-acetyl group

Carbon 6 of the glucosamine

Carbon 2 of the glucuronate

replace carboxyl carbon on iduronate

Term

 

The highly negative charge of heparin allows it to bind to ____.

Definition

Antithrombin III

 

Which allows for it to have an important in anticoagulant effect

 

Term
What GAGs has only Alpha-1-4 bonds?
Definition
Heparin and Heparan Sulfate
Term
What GAG is comprised of galactose and N-acetylglucosamine?
Definition
Keratan Sulfate
Term
Keratan Sulfate is most abundant in what?
Definition

Cartilage

 

Discs 

Term

 

Where is the core protein of proteoglycan synthesized?

Definition

 

Rough Endplasmic Reticulum

Term
Where are the GAGs assembled on to the core protein?
Definition

 

Golgi Apparatus

Term

 

What enzyme adds sugars to the core protein of proteoglycans?

Definition
Glycosyl Transferase
Term

 

What is aggrecan?

Definition

 

A proteoglycan that is predominant in cartilage. It contains over 100 GAGs

Term
Decorin is a proteoglycan that contains how many GAGs?
Definition

 

 

one

Term

 

What proteoglycan can be found in the basal lamina and functions for structure and filtering?

Definition

 

Perlecan

Term

 

Serglycin is found where? And does what?

Definition

a proteoglygan


Found in secretory vesicles

 

Packages and stores secretory molecules

Supporting users have an ad free experience!