Term
| Site of synth and effect of glucocorticoids |
|
Definition
| Adrenal cortex; protein catabolism and gluconeogenesis |
|
|
Term
| Site of synth and effect of mineralcorticoid |
|
Definition
| adrenal cortex; sodium retention and potassium excretion. indirect effect is incr in blood vol and BP |
|
|
Term
| Site of synth and effect of androgens |
|
Definition
| testes; spermatogenesis, secondary male characteristics, bone maturation, virilization |
|
|
Term
| Site of synth and effect of estrogen |
|
Definition
| ovary; feminization, cyclic rhythms, maintains bone density |
|
|
Term
| Site of synth and effect of progestin |
|
Definition
| placenta and ovary- corpus luteum; nidation, maintenance of pregnancy, cyclic rhythms |
|
|
Term
| where is pregnenolone synth? |
|
Definition
| matrix side of inner mitoch memb |
|
|
Term
| What does synth of prengnolone req (MITOCHONDRIAL hydroxylation rxn) and what stims its synth |
|
Definition
| reqs NADPH, adrenodoxin reductase, adrenodoxin, and cytochrome P450; Stim by ACTH |
|
|
Term
|
Definition
|
|
Term
| where is cholest hydroxylized to form pregnenolone? |
|
Definition
|
|
Term
| where does first step of steroid horm synth take place? |
|
Definition
| mitoch; cholest-->pregnenolone |
|
|
Term
| What does synth of glucocorticoids in adrenal cortex req (MICROSOMAL AKA ER hydroxylation rxns) |
|
Definition
| NADPH, cytochrome P450 reductase, and cytochrome P450 |
|
|
Term
| What is the only extra enzyme in cholest--> cortisol compared to cholest-->corticosterone |
|
Definition
|
|
Term
| Key enzyme for directing steroids into synth of glucocorticoids, androgens, and estrogens found in ER of all steroid secreting cells |
|
Definition
|
|
Term
| How many carbons designates an androgen |
|
Definition
|
|
Term
|
Definition
| Testosterone (C19)--> Estradiol (C18); Forms aromatic ring |
|
|
