Term
| What enzyme is defective in juvenile Parkinson's? |
|
Definition
| Parkin- an E3-ubiquitin-ligase |
|
|
Term
| What does the HPV virus do? |
|
Definition
| encodes an E3-ubiquitin ligase that targets p53 for degradation |
|
|
Term
| What is defective in Huntington's and what does it due |
|
Definition
| defective htt protein binds to proteasomes and inhibits degradation of other proteins which accumulate and cause neurodegeneration |
|
|
Term
| What do parietal cells of stomach release |
|
Definition
|
|
Term
| what do chief cells of stomach release |
|
Definition
|
|
Term
| Where does trypsin cleave |
|
Definition
|
|
Term
| Where does elastase cleave cleave |
|
Definition
|
|
Term
| Where does chymotrypsin cleave |
|
Definition
| after cyclic, aromatic AA's |
|
|
Term
| Three AA's used for 10% of nrg for extrahepatic tissues |
|
Definition
| valine, leucine, and isoleucine |
|
|
Term
| Phenylalanine hydroxylase |
|
Definition
| converts phenylalanine to tyrosine |
|
|
Term
| What enzyme do phenylketonuria (PKU) patients use to metabolize phenylalanine |
|
Definition
| aminotransferase; converts pyruvate to alanine in process |
|
|
Term
| tyrosine aminotransferase- deficiency |
|
Definition
| 1. tyrosine--> p-hydroxyphenylpyruvate; deficient in type II tyrosinemia |
|
|
Term
| p-hydroxyphenylpyruvate dioxygenase-deficiency |
|
Definition
| 2. p-hydroxyphenylpyruvate--> homogentisate; deficient in type III tyrosinemia |
|
|
Term
| homogentistate 1,2-dioxygenase- deficiency |
|
Definition
| 3. homogentistate-->maleylacetoacetate; deficient in alkaptonuria |
|
|
Term
| Maleylacetoacetate isomerase |
|
Definition
| 4. Maleylacetoacetate--> fumarylacetoacetate |
|
|
Term
| fumarylacetoacetase- deficiency |
|
Definition
| 5. Fumarylacetoacetate--> acetoacetate; deficiency in type I tyrosinemia |
|
|
Term
| 3-ketoacyl-CoA transferase |
|
Definition
| 6. acetoacetate--> acetoacetyl-CoA |
|
|
Term
| Cause of maple syrup urine disease |
|
Definition
| branched-chain alpha-ketoacid dehydrogenase |
|
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