Term
| oxidation of malate to form oxaloacetate |
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Definition
| 2H+ are produced resulting in NAD--->NADH + H+ |
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Term
| Cu(+) + Fe(3+) ---> Cu(2+) + Fe(2+) |
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Definition
- copper is oxidized
- iron is reduced |
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Term
| oxidizing agent always written on the... |
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Definition
| left, reducing agent is always on the right |
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Term
| Significance of reduction potential |
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Definition
- the measure of the tendncy of a substance to be oxidized or reduced by other substances, or the affinity a substance has for electrons
- high reduction potential means:
-it has a high affinity for e-
-it is not likely to be oxidized by other substances
-it is likely to be reduced
- it is a good oxidizing agent
**e- spontaneously flow from low E' to low E' |
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Term
| Respiratory electron transport |
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Definition
| - series of redox reactions associated with mitochondria where the electrons of reduced nucleotides produced in glycolysis and the TCA cycle are transferred througha series of electron carrieers ultimately to oxygen to form H2O |
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Term
| 4 membrane complexes are involved in respiratory electron transport |
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Definition
complex I - NADH dehydrogenase
Complex II - succinate DH complex
Complex III - Cytochrome b/c1 complex
Complex IV - cytochrome c oxidase
- all are on inner membrane |
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Term
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Definition
| - entry point for NADH bound electrons from glycolysis and TCA |
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Term
| Four important biomolecules in respiratory electron transport |
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Definition
- flavoproteins - contain flavin nucleotides and effect single or double transfers
- Fe-S proteins - non-heme proteins contain 2-4Fe atoms bound to protein via cysteine residues and are single e- transfers
- cytochromes are heme proteins and contain a single Fe atom that carry/transfer a single e-
- ubiquinone (coenzyme Q) - non-protein lipophilic molecule that carries 2e- |
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Term
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Definition
- contain tightly bound Flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD)
- both carry 2e- and 2H+ and are derived from riboflavin |
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Term
| functional domain of Fe-S Proteins |
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Definition
| - each Fe atom forms a sulfide and are bound to the complex via S of cysteine |
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Term
| Functional domains of cytochromes |
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Definition
- contain hemes covalently bound via cysteine residues
- histidine and methionine coordinate Fe and prevent 02 binding |
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Term
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Definition
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Term
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Definition
| captures from matrix and releases into intermembrane space |
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Term
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Definition
| proton gradients are not established as a result from complex II |
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