Term
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Definition
| Antigens, hormones, neurotransmitters, touch |
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Term
| Name four features of signaling transducing systems |
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Definition
| Specificity, amplification, desensitization, integration |
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Term
| Name the 5 different receptor types |
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Definition
| G-protein, Enzymes, Ligand-gated channels, Integrin Receptors, Nuclear receptors |
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Term
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Definition
| Prganic molecules(adrenaline), Polysaccharides(heparin), Peptides(insulin), Proteins(VEGF) |
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Term
| Name the 6 different types of Signal Transducers |
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Definition
| G-proteins(epinephrine), Tyrosine Kinase Receptor(proteins), Guanylyl Cyclase(cGMP), Integrin(adhesion receptor), Gated ion channel(ACh), Nuclear Receptor(steroids) |
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Term
| Close to 50% of all drugs on the market target what type of receptor? |
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Definition
| G-Protein coupled receptors |
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Term
| Which type of receptor mediates the effects of epinephrine? |
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Definition
| beta-adrenergic receptors |
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Term
| How do beta-adrenergic recpetors cause effects? |
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Definition
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Term
|
Definition
| a structurally similar molecule to the binding ligand |
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Term
|
Definition
| agonist drug for epinephrine used for patients with bradycardias and heart block |
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Term
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Definition
| antagonist drug for epinephrine used to lower BP and HR (beta-blocker) |
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Term
| Name the 3 essential components of a G-protein |
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Definition
| 7 transmembrane helical segments, effector EZ generating a 2nd messenger, Gprotein that acitvates a cascade |
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Term
| Name some signals that use cAMP as a 2nd messenger |
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Definition
| Corticotropin(cortisol), Glucagon(insulin release), Serotonin(depression-SSRI), Somatostatin(inhibits insulin) |
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Term
| Name some signals that use Phospholipase C,IP3, and Ca2+ |
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Definition
| Angiotension II(vasoconstrictor-ace inhibitors), Vasopressin(water retention) |
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Term
| Name the most common catalytic domain receptor type |
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Definition
|
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Term
|
Definition
| It auto-phosphorylates itself and causes a conformational change allowing binding for specific proteins/adds phosphate group to tyrosine in specific proteins |
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Term
| What type of receptor is EGFR? |
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Definition
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Term
| Cancer can result when what receptor has a mutation? |
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Definition
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Term
| All EGF pathways lead to what two main results in the cell? |
|
Definition
| Protein synthesis and cell survival/proliferation |
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Term
| Name two places that a cancer drug could be used to block EGFR |
|
Definition
| Ligand binding receptor and TK inhibitors)specifically prevents Phosp.) |
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Term
| Name a monoclonal antibody that can be used in the treatment of cancer concerning the EGFR |
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Definition
| Cetuximab-binds to EC domain preventing ligand binding |
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|
Term
| Name a TKI that is used in the treatment of cancer concerning the EGFR |
|
Definition
| Gefitinib-blocks (P) of TK by binding to the ATP binding site |
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Term
| Name the type of receptor that acts in the nucleus and alters gene expression |
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Definition
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Term
| Name the drug that is used in the treatment cancer where cell division is effected by estrogen production |
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Definition
| Tamoxifen-antagonist for estrogen |
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|
Term
| Name the phases of the cell cycle in the order they occurr |
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Definition
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|
Term
| What process occurs during G1? |
|
Definition
| Protein and RNA synthesis |
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|
Term
| What occurs during the S phase? |
|
Definition
|
|
Term
| What events occurs during the G2 phase? |
|
Definition
| Preparation for cell division |
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|
Term
| What occurs during Mitosis? |
|
Definition
| division and cytokinesis of the cell |
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|
Term
| What occurs during the G0 phase? |
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Definition
| Cells are checked for mutations and either destroyed or released to their destinations |
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|
Term
| What controls the timing of the cell cycle? |
|
Definition
| Cyclin Dependent protein kinase |
|
|
Term
| Name the regulatory subunit, catalytic subunit, and route of activity for the CDPK |
|
Definition
Reg. subunit: cyclin
cat. subunit: PK
activity:(P) |
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|
Term
| What phase does CDK work in? |
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Definition
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