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Bio Impacts/Issues Exam 1
Dr. Koppenheffer
48
Biology
Undergraduate 1
02/07/2009

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Term
importance of infectious diseases
Definition
Prevalent in 3rd world countries, related to ecological changes, economic development, international travel and commerce, technology, industry, globalization, related to agriculture and climate change
Term
difficulties presented by microbes/pathenogenic microbes
Definition
Ability to spread rapidly, related to human demographics, societal events, population growth, migration to cities, war/civil conflict, urban decay, sexual behavior, IV drug use

Microbial adaptation, change in environment
Term
microbes as essential components to Earth's ecosystem (4 reasons)
Definition
1. Generate O2 in atmosphere
2. Recycle nutrients stored in organic matter in an inorganic form - ultimate decomposers!
3. Fix N2 from atmosphere into a useable form - and other biogeochemical cycles
4. Give plant roots access to soil’s nutrients - essential to the CARBON CYCLE
Term
prokaryote
Definition
No distinct nucleus
Somewhat simpler composition
Bacteria have cell wall or cell membrane
Viruses as obligate parasites – inject DNA into host in order to reproduce
Ex) archea, bacteria
Term
eucaryote
Definition
Distinct nucleus with a nuclear membrane
Have organelles
Animals don’t have cell walls, plants do
Reproduce sexually
Ex) fungi, protozoa, multicellular parasites
Term
Pasteur
Definition
breakthroughs in causes and prevention of disease, discovered germ theory of disease, and first vaccines
Term
Redi
Definition
challenged the theory of spontaneous generation though experiment with pieces of meat that grew maggots without the airtight container
Term
Lister
Definition
discovered first antiseptics – how to kill germs (bc dumb students working with cadavers did not wash hands before touching babies)
Term
Robert Koch
Definition
isolated anthrax from dead cows, created the Germ Theory of Disease, also discovered TUBERCULOSIS
Term
Jenner
Definition
worked with Pasteur exposing young boys to cowpox (pedafile), figured out that genetic material is the basis for change
Term
REPLICATION (transcription, translation)
Definition
DNA splits into 2 single stranded pieces, find bases (TAGC) in nucleus and reattach to these new pairs that were once floating around in the nucleus.
Term
(replication) TRANSCRIPTION (translation)
Definition
DNA unwinds and RNA reads the data (of one of the strands), copies down its opposite in its transcription. It works as a messenger.
Term
(replication, transcription) TRANSLATION
Definition
The RNA transcribed is translated into a protein sequence of 3 code letters which compose an animo acid. A chain of amino acids makes up a protein. The codon (on the mRNA) contains these three letters and combines with an anticodon (a part of the tRNA) during the translation phase in order to make a protein.
Term
DNA 3’ T C A 5’
what are the corresponding mRNA and tRNA codon sequences?
Definition
DNA 3’ T C A 5’
mRNA 5’ A G U 3
tRNA 3’ U C A 5’

A=T
G=C
DNA never has "U"
mRNA and tRNA never have "T"
Term
What cell organelles participate in protein synthesis, and what do they “do”?
Definition
ribosome’s – 2 subunits attach to RNA molecule and translate it.
Term
point mutations and their potential outcomes
Definition
at one point in the strand, one letter is changed, forming a new amino acid, and therefore a new protein (just because one letter is copied down incorrectly)
Term
primary structure of proteins
Definition
3 letter code that corresponds to a particular amino acid, thus forming a particular order of amino acids
Term
secondary structure of proteins
Definition
alpha helix or beta pleated sheet shape – certain amino acids favor either type based on the primary structure
Term
tertiary structure of proteins
Definition
combination of all the alpha helices AND beta pleated sheets
Term
quaternary structure of proteins
Definition
2 or more proteins coming together to make up multiple proteins
Term
carbohydrates
Definition
sugars, stored as energy, react with water
Term
lipids
Definition
fats, hydrophobic, no reaction with water
Term
proteins
Definition
functional, structural enzymes, composed of chains of amino acids, react with water
Term
nucleic acids
Definition
specific to DNA and RNA – they code the message of life, synthesizing proteins
Term
ATP
Definition
Ultimate source of energy for all metabolic reactions.
Term
anabolic reactions
Definition
build up complex molecules (ex. Dehydration synthesis)
Term
catabolic reactions
Definition
break down molecules into smaller components (ex. Hydrolysis)
Term
role of water in reactions
Definition
Hydrolysis: breaks down carbohydrates – the bonds between the molecules
Term
enzyme
Definition
type of protein made up of amino acids. They speed the reaction by lowering the activation energy necessary for the reaction, or by making conditions more favorable for a reaction to occur. Without enzymes, reactions would occur far too slowly and life could not exist.
Term
gram-positive bacteria
Definition
retain the crystal violet dye, have a high amount of peptidoglycon in the cell wall, lack an outer membrane, have strong protein/carb structures
Term
gram-negative bacteria
Definition
do not retain the crystal violet dye, more likely to be pathenogenic (harmful!!), and have an LPS – lipopolysaccharide layer
Term
transformation
Definition
change due to the acquisition of genetic material - acquisition of different genetic material acquired from outside (mixed with live cells from another strain)
Term
conjugation
Definition
change due to acquisition of new genetic material - defective phages can infect, but not reproduce. There is direct cell-to-cell contact
Term
transduction
Definition
change due to acquisition of new genetic material - DNA transferred through a virus – results in foreign DNA introduced into another cell
Term
tuberculosis
Definition
Very serious viral infection, leading cause of death from a single bacteria, 2 million a year are killed, it is highly communicable.
Caused by tubercle bacillus, 1882 discovered by Robert Koch
Term
threat of tuberculosis
Definition
should be treatable through antibiotics, BUT there is too much patient complacency, and it is spread even more easily through travel, high population densities, and HIV – lowers the resistance of the immune system.
Term
tuberculin test
Definition
A protein derivative of the virus is injected intradermally (into the skin) and if the body previously had contact with tuberculosis, it will recognize it and the skin will swell. But just because it is positive does not mean the virus is active, it only means there has been recent exposure.
Term
virus vs. prokaryote
Definition
VIRUSES ARE OBLIGATE PARASITES. They must reproduce after affecting cell and they use the host cell’s ribosome’s and they synthesize/create enzymes.
Term
bacilli
Definition
rod-shaped bacteria
Term
spirilla
Definition
spiral-shaped bacteria
Term
streptoccoci
Definition
chains of cocci - look like a strand of pearls
Term
cell wall
Definition
a structure of bacteria, plants, algae, and fungi cells, and is reponsible for resistance to the cell from inward diffusion of water
Term
importance of gram positive vs. gram negative classification of bacteria
Definition
determines type of antibiotic, related to cell wall
Term
plasmids
Definition
small molecules of nonchromosomal DNA found in some bacteria, located in the cytoplasm and are independent of the chromosomal DNA.
Term
binary fission
Definition
bacterial cells reproducing - in an exponential growth curve (lag phase, exponential phase, stationary phase. death phase)
Term
[image]
Definition
replication cycle of a bacterial virus
Term
[image]
Definition
DNA replication
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