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bio 400
ch.17/ch.18
10
Biology
Undergraduate 2
04/26/2017

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Term
chromosomal mutations
Definition
big changes in chromosomal structure
Term
point mutations
Definition
affect single base pairs
causes: errors in DNA replication or repair
mutagens: physical or chemical agents that damage DNA
2 types
Term
Base- Pair substitution
Definition
replacement of 1 base pair
ex. SNP
possible outcomes in protein coding region
Term
silent mutation
Definition
no change to aa sequence
Term
nonsense mutation
Definition
changes an aa codon to a stop codon, shortens the protein
Term
missense mutation
Definition
1 aa substitution
Term
Frameshift mutation
Definition
caused by bp insertion or deletion (indel)
-in protein coding region they shift down stream reading frame
-may cause: missense, nonsense mutations
Term
Positive form of Transcription Regulation
Definition
transcription requires help due to a weak promoter, one that can't bind RNA pol alone w/out DNA binding proteins called transcription factors
Ex. MyoD specialize as muscle cells
Term
negative form of transcription regulation
Definition
blocks transcription of genes whose default is on, for genes with strong promoters
Ex. Trp Operon: genes of 5 enzymes for trp synthesis containing operator and repressor protein
Term
RNA silencing
Definition
deflation of specific mRNA's before translation
-caused by miRNA with complementary sequence to target mRNA
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