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Bio 230: Immunodeficiency/Hypersensitivity
Immunodeficiency Diseases and Hypersensitivity (allergy)
49
Biology
Undergraduate 2
08/12/2009

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Term
Immunodeficiency
Definition
When all or part of the immune system is deficient.
Term

Primary

Secondary

Definition
Two types of immunodeficiency diseases.
Term
Primary Immunodeficiency
Definition
Immunodeficiency that is present at birth, is rare and often fatal.
Term
Secondary Immunodeficiency
Definition
Immunodeficiency that is not present at birth, develops during the lifetime, is common and rarely fatal.
Term

B-lymphocyte deficiency

T-lymphocyte deficiency

Definition
Two main types of Primary Immunodeficiency
Term
having less B-lymphocytes than normal
Definition
hypogammaglobulinemia
Term
having no B-lymphocytes
Definition
agammaglobulinemia
Term
agammaglobulinemia
Definition
Type of B-lymphocyte deficiency that will lead to death.
Term
B-lymphocytes deficiency
Definition
Have less than normal or no antibodies.
Term

Lack of newborn cells

Lack of functional GALT

Definition
Two causes for B-lymphocyte deficiency
Term

Keep child away from infections

Give antibiotics at first sign of infection

Give antibodies (passive artificial)

Bone marrow transplant

Definition
Four treatments for B-lymphocyte deficiency.
Term
T-lymphocyte deficiency
Definition
Having less than normal or no T4, T8, Th1, Th2, CTL, etc... cells.
Term

Lack of newborn stem cells

Lack of a functional Thymus gland

Definition
Two causes for T-lymphocyte deficiency.
Term

Keep away from infections

Keep away from cancer causing agents

Give antibiotics at first sign of infection

Give antibodies

Bone marrow transplant

Stem cells + Thymus transplant

Definition
Six treatments for T-lymphocyte deficiencies.
Term

T-lymphocyte deficiency

 

(lack of CTL)

Definition

People with this type of primary immunodeficiency are more likely to get cancer.

 

(why)

Term

stress

lack of nutrition

lack of sleep

pregnancy

infections

smoking

alcohol

radiation

medications

Definition
9 causes of Secondary immunodeficiency
Term
allergy
Definition
hypersensitivity
Term
hypersensitivity (HS)
Definition
Over reaction by some part of the immune system which causes harm to self.
Term

Multiple exposures to the same large Agn

First exposure to very high levels of large Agn

Definition
When HS can occur...
Term
allergen
Definition
What the Agn is referred to when overreaction occurs...
Term

proteins

lipids

Definition
What most allergens are (chemically)...
Term

Immediate HS

Delayed HS

Definition
Two main types of HS
Term
Immediate HS
Definition
Symptoms of allergy appear within 48 hours of exposure to the allergen.
Term
Immediate HS
Definition
HS that involves a B-lymphocyte-Aby reaction
Term
Delayed HS
Definition
Type of HS where symptoms of allergy appear 48 hours or more after exposure to allergen.
Term
Delayed HS
Definition
Type of HS that involves a T-lymphocyte reaction.
Term

Anaphylactic reaction

Arthus reaction

Auto-immune reaction

Definition
Three kinds of Immediate HS
Term
Anaphylactic reaction
Definition
Is due to many exposures to same antigen and can stimulate excess IgE production in some people.
Term
IgE attach to epitope, which then attach to mast cells. Each successive exposure to allergen causes more IgE-epitope to attach to mast cells causing them to burst, releasing histamine and causing inflammation.
Definition
What happens when excessive IgE is produced in anaphylactic reactions.
Term

Skin

Respiratory Tract

Internally through ingestion

Systemic

Definition
Where contact with allergen can occur causing inflammation.
Term

rash

hives

Definition
Symptoms of inflammation when allergen makes contact with the skin.
Term

Difficulty breathing

Closes pharynx, larynx, trachea, bronchi

Definition
Symptoms of inflammation when allergen makes contact with the respiratory tract.
Term

diarrhea

vomiting

closing of pharynx

Definition
Symptoms of inflammation when allergen is ingested.
Term

severe inflammation of the lungs

great respiratory difficulty

anaphylactic shock

death

Definition
Symptoms of inflammation when allergen is systemic.
Term

blood vessel damage

hypertension

hemorrhage

heart failure

Definition
Four symptoms of anaphylactic shock.
Term

Stay away from allergen

Anti-histamines

Adrenaline, epinephrine

Allergy shots

Definition
Four treatments for immediate HS causing anaphalactic reactions.
Term
It is a vaso-constrictor, which works to reduce inflammation and increase blood flow to the heart.
Definition
How adrenaline/epinephrine works as a treatment for HS.
Term
Helps people produce IgG antibodies.
Definition
How allergy shots work as a treatment for HS.
Term

serum sickness

immune complex reaction

Definition
Two other names for arthus reaction.
Term
Single large dose of allergen in blood.
Definition
What causes an arthus reaction...
Term
Allergen, antibody and complement form an immune complex in blood, which can result in blood vessel damage.
Definition
What happens during an arthus reaction...
Term
auto-immune reaction
Definition
cytotoxic reaction
Term
auto-immune reaction
Definition
Production of antibodies against self or possibly altered self.
Term

Rheumatic heart disease (fever)

Systemic Lupus Erythematosis (SLE, lupus)

Rheumatoid arthritis

Definition
Three examples of auto-immune reaction in immediate HS.
Term
Rheumatic fever
Definition
Production of antibodies against protein found in mitral valve of heart.
Term
Lupus
Definition
Production of antibodies against DNA.
Term
Rheumatoid arthritis
Definition
Production of antibodies against a protein in joint tissue.
Term

Contact dermatitis

Skin tests

Transplant rejection

Definition
Three kinds of delayed HS.
Term

plant allergies

cosmetic allergies

latex allergies

insect stings

Definition
4 common causes of contact dermatitis.
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