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BIO 230: Cellular Immunity
Cell-mediated immunity
20
Biology
Undergraduate 2
08/10/2009

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Term

1. Exogenous Agn is picked up by tissue macrophage

2. Macrophage binds to Agn and exposes epitope

3. Epitope is transferred to T4 cell 

4. T4 cell with epitope attached to TCR is now activated (Activated T4 cell)

5. Activated T4 cell can now become a Th1 or Th2 cell

6. Th1 cell produces and secretes chemicals called cytokines or Lymphokines

7. Th2 cell transfers epitope to surface of a B-lymphocyte.

8. B-lymphocyte becomes a plasma cell, which makes antibodies.

Definition
Steps involved in Cellular Immunity when an exogenous antigen is present.
Term
Antigen Presenting Cell
Definition
APC
Term
Tissue macrophage
Definition
Antigen Presenting Cell (APC)
Term
Th1 cell
Definition
T-helper type 1
Term
Th2 Cell
Definition
T-helper type 2
Term
  1. Macrophage attracting factor
  2. Macrophage activating factor
  3. Macrophage migration inhibition factor
  4. Mitogenic factor
  5. Interferon
  6. NK cell stimulating factor
  7. Tumor Necrosis factor
Definition
Seven examples of cytokines in exogenous cellular immunity.
Term
Surface immunoglobulin
Definition
sIg
Term
mitogenic factor
Definition
cytokine that stimulates macrophages to multiply
Term
T4 Cell Receptor
Definition
TCR
Term

Opportunistic bacteria

Slow virus

Cancer

Definition
Examples of endogenous antigens.
Term

1. Endogenous antigen is picked up by APC.

2. APC binds to Agn and exposes epitope.

3. Epitope is transferred to T8 Cell and is activated.

4. Activated T8 cell can now become one of the following cells:   Th1 cell, Th2 cell, CTL, T-memory cell or a

T-suppressor cell.

Definition
Process involved in cellular immunity when an endogenous antigen is present.
Term

Th1 Cell

Th2 Cell

CTL

T-memory cell

T-suppresor cell

Definition
Five cells an activated T8 cell can become.
Term

Macrophage attracting factor

Macrophage activating factor

Macrophage migration inhibition factor

Macrophage mitogenic factor

Interferons

Lymphotoxin

Tumor necrosis factor

Definition
7 examples of cytokines involved in endogenous cellular immunity.
Term
cytokines
Definition
What a Th1 Cell produces...
Term
Lymphotoxin
Definition
Cytokine that destroys cancer cells and transplants.
Term
cytotoxic T-lymphocyte
Definition
CTL
Term
cytoxoic T-lymphocyte (CTL)
Definition

anti-cancer lymphocyte that destroys tumor cells and transplants.

 

Term

T-memory cell

(T16 cells)

Definition
retains epitope on its surface as a reminder
Term

T-suppressor cells

 (T25 cells)

Definition
Shut down reproduction and activity of all other T-lymphocytes.
Term
transfers epitope to surface of a B-lymphocyte
Definition
What a Th2 cell does...
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