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BIO 230 Microbiology VIII
Viruses
45
Biology
Undergraduate 2
07/23/2009

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Term
Viruses
Definition
Some of the smallest known infectious agents, measured in nanometers.
Term
Poliovirus (1-10nm)
Definition
One of the smallest known viruses
Term
Poxvirus (250nm)
Definition
One of the largest known viruses
Term
virus
Definition
nucleocapsid or nucleoprotein
Term

protein head, called a capsid, containing RNA or DNA

possible spikes

Definition
Physical structure of an animal virus
Term

1. Can be reproduced at a rapid rate

2. Can be mutated

3. Have nuclear material (DNA or RNA)

Definition
Living Characteristics of Viruses
Term

 

  1. Have no cell structure
  2. No cytoplasm
  3. Contain no water
  4. Have few, if any, enzymes
  5. Carry out no metabolic reactions
  6. Obligate intracellular parasites
  7. Not free-living
Definition
Non-living characteristics of viruses
Term

Viruses cannot be seen w/light microscopes

Viruses cannot grow on agar plates

Viruses have either DNA or RNA, not both

Definition
How we diagnose viral infections.
Term

Animal viruses

Plant viruses

Bacterial viruses

Fungal viruses

Definition
Types of Viruses
Term
bacteriophage
Definition
Another name for bacterial viruses.
Term
mycophage
Definition
Another name for fungal viruses
Term
species; tissue
Definition
Viruses are specific to ________ and _________.
Term

Icosahedral

Helical or cylindrical

Complex

Definition
Three Common shapes of viruses
Term
Icosahedral shape
Definition
Shape of typical animal virus that has a geometrical shape with capsomeres, a capsid and has a hollow inside containing DNA or RNA.
Term
Helical/Cylindrical
Definition
Shape of typical plant viruses that look like hollow bullets, with a capsid and contains RNA.
Term
Rabies
Definition
Animal virus that has a helical shape and has been known to cross over between species.
Term
Icosahedral
Definition
Shape of virus that is primarily animal viruses.
Term
Helical or Cylindrical
Definition
Viral shape that is primarily plant viruses.
Term
Complex Shape
Definition
Viral shape that is bacterial viruses (bacteriophage)
Term

hollow capsid containing DNA

collar

tail

base plate

sheath

tail fibers

pins

Definition
Structures on a bacteriophage
Term
adsorption
Definition
attachment of virus to a host cell
Term

a. adsorption

b. entry of virus by endocytosis

c. host uncoats virus, DNA is released

d. host cell transports DNA to nucleus

e. host cell attaches viral DNA to its chromosome

f. host cell is shut down and taken over by virus

g. host cell reproduces viral DNA

h. host cell produces new viral heads/spikes

i. mature viruses are assembled

j. mature viruses are released by "budding out"

k. re-infection of another cell, initial cell dies

 

Definition

Steps of the Productive Life Cycle

of an Animal Virus

Term
10,000 - 50,000
Definition
number of viral DNA reproduced by animal host cell in a few hours
Term
envelope
Definition
When the virus leaves the host cell by reverse endocytosis, it may take a piece of the cell membrane called an ___________.
Term
Assembly of Mature viruses
Definition
When viral DNA is carried to the host cell ribosomes and inserted into the viral heads.
Term

Steps a. - e. are identical

After viral DNA is added to the host cell chromosome, there is no shut down of the cell and the virus does not take over.

The viral DNA is copied with the host DNA everytime it divides.

Virus becomes a Provirus

If Provirus separates from the host DNA, then it triggers the rest of the productive life cycle.

Definition
Provirus Life Cycle of Animal Virus
Term
slow virus disease
Definition
Viral disease that spends various amounts of time as a provirus in the host cells.
Term
Productive Life Cycle
Definition
When a virus shows symptoms, it is in this life cycle.
Term
productive life cycle
Definition
When viruses are contagious.
Term
mutation
Definition
When virogene separates from the host chromosome, it may cause this to occur in the host cell DNA.
Term
cell transformation
Definition
Mutation of the host cell DNA may lead to this.
Term
cancer
Definition
cell transformation
Term
30
Definition
Number of human viruses known to cause cancer.
Term

a. adsorption

b. injection of DNA via tail

c. viral DNA attaches to host DNA

d. partial shut-down and take-over of host

e. viral DNA is copied

f. viral heads/tails are made

g. assembly of mature viruses

h. host bacteria bursts and viruses are released

i. re-infection of another bacteria

Definition
Lytic Life Cycle of Bacteriophage
Term
50-200
Definition
Number of bacteriophage DNA copies made in a few hours.
Term

a. adsorption

b. injection

c. attachment to host DNA

- No shut down, no take-over

-prophage remains until viral DNA separates from host.

 

Definition
Lysogenic Life Cycle of Bacteriophage
Term

Protease inhibitors

Anti-nuclear medications

Definition
Two kinds of antiviral medications
Term
block the production of viral capsid proteins by the host cell
Definition
How protease inhibitors work...
Term
interfere with replication of viral DNA/RNA by the host cell
Definition
How antinuclear medication work...
Term

acyclovir

amantadine

idoxuridine

methisazone

AZT, ddI, ddC, etc

Definition
example of specific antiviral medications
Term

Neutralizing Antibodies

Interferons

Definition
Two Main Body Defenses against Viruses
Term
Neutralizing antibodies
Definition
Proteins made by the immune system against  specific viruses by covering the head of the virus to prevent viral attachment to host cells.
Term
Interferons
Definition
Non-specific proteins made by virus infected cells that pass into surrounding cells and prevent viruses from shutting down, taking over and being replicated.
Term
neutralizing antibodies
Definition
are generally a lifelong defense against viruses
Term
interferons
Definition
are produced each time a viral infection occurs
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