Term
|
Definition
river of life blood carries the "vital force" life sustaining fluid |
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Term
|
Definition
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Term
|
Definition
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Term
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Definition
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Term
| functions of the circulatory system |
|
Definition
transport protection regulation |
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Term
| blood functions in transport - explain |
|
Definition
| transports O2, CO2 and nutrients to body cells, metabolic wastes to kidneys, hormones to target cells, stem cells from bone marrow and other origins to tissues where they lodge and mature |
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|
Term
| blood functions in protection from infection and blood loss - explain |
|
Definition
inflammation WBC antibodies and complement proteins platelets |
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Term
|
Definition
| mechanism for limiting spread of infection |
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|
Term
| how do WBC protect from infection |
|
Definition
| destroy pathogens and cancer cells |
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|
Term
| how do antibodies and complement proteins protect |
|
Definition
| neutralize toxins and pathogens |
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Term
|
Definition
| initiate clotting and minimize blood loss |
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Term
| blood functions in regulation |
|
Definition
by absorbing or giving off fluid stabilize fluid distribution buffers acids and bases in blood thus stabilizing pH shift in flow regulate body temp |
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Term
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Definition
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|
Term
| what is the matrix of blood? (not fluid) |
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Definition
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Term
| what are formed elements? |
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Definition
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|
Term
| what are 3 formed elements |
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Definition
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Term
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Definition
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Term
|
Definition
|
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Term
|
Definition
|
|
Term
| what are 2 categories of leukocytes |
|
Definition
granulocyres agranulocytes |
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Term
|
Definition
neutrophils eosinophils basophils |
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Term
|
Definition
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Term
| what is it called when one separates formed elements from plasma |
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Definition
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Term
| straw color top part of centrifuged blood |
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Definition
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|
Term
| what is the buffy coat of centrifuged made of |
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Definition
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|
Term
| what are packed at the bottom and red of centrifuged blood |
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Definition
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|
Term
| what are the densest formed elements |
|
Definition
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Term
| 45% of total volume of blood |
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Definition
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Term
| what is a mixture of dissolved nutrients, gases, hormones, waste, enzymes and proteins |
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Definition
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Term
| what is a mixture of water, proteins, nutrients, electrolytes, nitrogenous wastes, hormones, gases |
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Definition
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|
Term
| what is plasma minus fibrinogen |
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Definition
|
|
Term
| what are the most abundant plasma solute |
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Definition
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|
Term
| 3 major categories of plasma proteins |
|
Definition
albumin globulin fibrinogen |
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Term
| most abundant protein in the plasma |
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Definition
|
|
Term
| what protein serves to transport solutes and buffer pH |
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Definition
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|
Term
| what are albumins a major contribution to |
|
Definition
viscosity - thickness osmolarity - how many solids are in the blood |
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|
Term
| what do changes in albumin concentration cause |
|
Definition
| significantly affect blood volume, blood pressure and blood flow |
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Term
|
Definition
osmotic pressure blood viscosity transport lipids, hormones, Ca and buffers pH |
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|
Term
| what are 3 subclasses of globulins |
|
Definition
alpha globulins beta globulins gamma globulins |
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Term
| 2 examples of alpha globulins |
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Definition
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|
Term
| function of ceruloplasmin |
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Definition
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Term
|
Definition
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|
Term
| functions of other alpha globulins |
|
Definition
| transport lipids, fat souble vitamins and hormones |
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Term
| 2 examples of beta globulins |
|
Definition
transferrin complement proteins |
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Term
|
Definition
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|
Term
| function of complement proteins |
|
Definition
| aid in destruction of non-specific toxins and pathogens |
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Term
| 2 other names for gamma globulins |
|
Definition
immunoglobulins antibodies |
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Term
|
Definition
| specific proteins made by plasma cells that combat specific pathogens |
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|
Term
| what does fibrinogen become |
|
Definition
| fibrin - a major component of blood clots |
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|
Term
| what produces all the major plasma proteins except gamma globulins |
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Definition
|
|
Term
| where are gamma globulins descended from |
|
Definition
| WBC's called B lymphocytes |
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|
Term
| 2 nitrogen-containing compounds are in plasma |
|
Definition
amino acids nitrogoneous wastes |
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Term
| toxic products of catabolism |
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Definition
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|
Term
| most abundant nitrogenous waste |
|
Definition
|
|
Term
| product of AAs catabolism |
|
Definition
|
|
Term
|
Definition
|
|
Term
| what nutrients does blood plasma transport |
|
Definition
| AA, glucose, FA, glycerol, triglycerides, cholesterols, phospholipids, vitamins and minerals |
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|
Term
| what electrolytes does blood plasma transport |
|
Definition
| Na, Ca, K, Mg, Cl, HCO3, HPO4, SO4 |
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|
Term
| what gases does blood plasma transport |
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Definition
|
|
Term
| the resistance of blood to flow resulting from cohesion of its particles |
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Definition
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|
Term
| thickness or stickiness of blood |
|
Definition
|
|
Term
| what decreases viscosity and causes blood to flow too easily |
|
Definition
|
|
Term
| what increases viscosity and cause blood to flow too slow |
|
Definition
| excesses of RBCs or proteins |
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|
Term
| the total dissolved particles that cannot pass throught the BV wall |
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Definition
|
|
Term
| 3 main contributors to blood osmolarity |
|
Definition
sodium ions proteins (albumins) RBCs |
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|
Term
| the transfer of fluids depends on a balance between the ____ of fluid from the capillary and its movement back into the capillary by ____ |
|
Definition
| filtration, reabsorption (osmosis) |
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|
Term
| high blood osmolarity cause the blood to reabsorb ____ water and ____ BP thus straining heart and BV |
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Definition
|
|
Term
| low blood osmolarity cause the tissues to retain ____ fluid and become ____ and ____ BP thus straining heart and BV |
|
Definition
| too much, edematous, decrease |
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|
Term
| production of blood and its formed elements |
|
Definition
|
|
Term
| tissues that produce blood cells |
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Definition
|
|
Term
| during embryonic development stem cells colonize 4 things |
|
Definition
bone marrow liver spleen thymus |
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|
Term
| bone marrow, liver, spleen and thymus stem cells, during embryonic development, produce |
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Definition
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|
Term
| after birth, what 3 things continue to produce lymphocytes for life |
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Definition
|
|
Term
| infancy onward, ___ produces all 7 kinds of formed elements |
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Definition
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|
Term
| infancy onward, the thymus, tonsils, lymph nodes and spleen produce |
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Definition
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|
Term
| blood formation in bone marrow |
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Definition
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|
Term
| blood formation in lymphatic organs |
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Definition
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|
Term
| most abundant formed element |
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Definition
|
|
Term
|
Definition
|
|
Term
| have a discoidal cell with biconcave shape |
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Definition
|
|
Term
| lack a nucleus and have a 120 day life expectancy |
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Definition
|
|
Term
| since RBC lacks a mitochondria, what does it rely on to produce ATP |
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Definition
|
|
Term
| cytoplasm of RBCs consist of |
|
Definition
hemoglobin CAH - carbonic anhydrase |
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|
Term
| what enzyme catalyzes CO2+H2O<-->H2CO3 |
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Definition
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|
Term
| plasma membrane of RBCs contain |
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Definition
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|
Term
| what determines a persons blood type |
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Definition
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Term
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| 3 measurements of RBCs and hemoglobin |
|
Definition
hematocrit hemoglobin concentration RBC count |
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|
Term
| whose RBC/hemoglobin values are lower, men or women |
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Definition
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|
Term
| why are hemoglobin/RBC values lower in women than in men |
|
Definition
androgens stim RBC production women have periodic menstual losses hematocrit is inversely proportional to percentage body fat blood clots faster in men men have fewer BV near skin |
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|
Term
| erythrocyte production called |
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Definition
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|
Term
| 8 steps in erythropoiesis |
|
Definition
1 hemopoietic stem cell becomes 2 erthryocyte colony-forming unit EFCU 3 ecfu have receptors for 4 erythropoietin (EPO) secreted from liver and kidney cells 5 EPO stimulates ECFU to become erythroblast that produce hgb 6 erythroblast lose nucleus and become reticulocytes 7 formation of reticulocytes (immature RBCs) are released from bone marrow into BV 8 day or twon, reticulocytes become mature erythrocyte |
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|
Term
| hormone secreted from liver and kidney in response to low levels of O2 |
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Definition
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|
Term
| stimulates bone marrow to produce RBC |
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Definition
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Term
|
Definition
|
|
Term
|
Definition
| kidneys and liver increase production and secretion of EPO which stimulates stem cells in bone marrow to increase RBC production |
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Term
|
Definition
low levels of atmospheric O2 increase in exercise hemorrhaging |
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|
Term
| nutritional requirements for erythropoiesis |
|
Definition
B12 and folic acid - for rapid cell division and DNA synthesis Vit C and copper - cofactors for enzymes Iron - hemoglobin |
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Term
|
Definition
|
|
Term
| ____ in liver and spleen phagocytize worn out RBC |
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Definition
|
|
Term
|
Definition
|
|
Term
| old RBCs become trapped and break apart within the spleen is called |
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Definition
|
|
Term
| whats released when RBC breaks |
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Definition
|
|
Term
| what can block kidney tubules and cause renal failure |
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Definition
|
|
Term
| phagocytize and separates heme from globin |
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Definition
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|
Term
| picks up iron that has been release from heme into blood |
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Definition
|
|
Term
| convert the leftover heme into biliverdin |
|
Definition
|
|
Term
|
Definition
|
|
Term
| bilirubin released from macrophage to ___ in the blood |
|
Definition
|
|
Term
| liver removes ___ from albumin and secretes it into the ___ |
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Definition
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
rapid hemolysis liver disease bile duct obstruction |
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Term
|
Definition
|
|
Term
| gut bacteria converts bilirubin to ___ |
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Definition
|
|
Term
|
Definition
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|
Term
| deficiency of either RBCs or hgb |
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Definition
|
|
Term
| 3 dangers of polycythemia |
|
Definition
increased BV increased BP increased blood viscosity |
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|
Term
| results from dietary deficiency of any requirements for erythropoiesis |
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Definition
|
|
Term
| lack of iron in diet (tyoe of anemia) |
|
Definition
|
|
Term
| deficiency of vitamin B12 (type of anemia) |
|
Definition
|
|
Term
| failure of stomach to produce intrinsic factor (type of anemia) |
|
Definition
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|
Term
| blood types based on large molecules called |
|
Definition
|
|
Term
| antigens can be 3 diff things |
|
Definition
proteins glycoproteins glycolipids |
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|
Term
| allows the body to distinguish its own cells from foreign cells with foreign antigens |
|
Definition
|
|
Term
| plasma cells secrete ___ when immune response is activated bc the body detects a foreign antigen |
|
Definition
|
|
Term
| bind to foreign antigens and mark the cell for destruction |
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Definition
|
|
Term
| each antibody binds to 2 or more foreign antigens and sticks them together in an antigen-antibody complex |
|
Definition
|
|
Term
| all cells have ___ on the surface of their cell membrane |
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Definition
|
|
Term
| id's your RBCs as unique to you |
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Definition
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|
Term
|
Definition
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|
Term
| antibodies in the plasma for foreign RBCs |
|
Definition
|
|
Term
| determined by hereditary with the presence/absence of antigen A and antigen B |
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Definition
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|
Term
|
Definition
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|
Term
| anti-B antibody in plasma |
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Definition
|
|
Term
|
Definition
|
|
Term
| anti-A antibody in plasma |
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Definition
|
|
Term
|
Definition
|
|
Term
| neither anti-A or anti-B antibodies in plasma |
|
Definition
|
|
Term
| neither antigen A or B on RBC |
|
Definition
|
|
Term
| both anti-A and anti-B antibodies in plasma |
|
Definition
|
|
Term
| anti-A antibody is against antigen |
|
Definition
|
|
Term
| anti-B antibody is against antigen |
|
Definition
|
|
Term
| its the recipient's ___ that agglutinate the donor's ___ |
|
Definition
|
|
Term
| the clumping of donated RBCs by recipients's antibodies |
|
Definition
|
|
Term
| true/false. you have antibodies in your plasma that react against your antigens |
|
Definition
|
|
Term
| in transfusion reaction, agglutinated RBCs can.... |
|
Definition
block small BV hemolyze and release hgb into the bloodstream |
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|
Term
| free hemoglobin can block ... |
|
Definition
| renal tubules leading to renal failure |
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
|
|
Term
| Rh+ has what antigen present on RBCs plasma membrane |
|
Definition
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|
Term
| Rh- does not have what antigen present on RBCs plasma membrane |
|
Definition
|
|
Term
| are anti-D antibodies normally present in the blood plasma |
|
Definition
|
|
Term
|
Definition
Rh- person has received Rh+ transfusion
Rh- mother carrying Rh+ fetus |
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|
Term
|
Definition
|
|
Term
| baby born with very few RBCs causes |
|
Definition
erythroblastosis fetalis hemolytic disease of newborn |
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|
Term
|
Definition
|
|
Term
| never has anti-D antibodies in plasma |
|
Definition
|
|
Term
| does not have antigen D on RBC |
|
Definition
|
|
Term
|
Definition
|
|
Term
| does not have anti-D antibodies in plasma |
|
Definition
|
|
Term
| how can Rh- blood be exposed to Rh+ blood |
|
Definition
transfusion carry Rh+ fetus |
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|
Term
|
Definition
|
|
Term
| abundant in the body tissue |
|
Definition
|
|
Term
| all WBC squeeze out of BV and into CT to search and destroy anything foreign |
|
Definition
|
|
Term
|
Definition
defend body against foreign material bacteria, viruses, parasites, toxins, tumors, tissue/organ transplants |
|
|
Term
| WBCs must synthesize ___ to carry out their functions |
|
Definition
|
|
Term
|
Definition
neutrophil basophil eosinophil lymphocyte monocyte |
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|
Term
|
Definition
|
|
Term
| found at site of bacterial infection |
|
Definition
|
|
Term
| carry out phagocytosis of bacteria aka "bacteria slayer" |
|
Definition
|
|
Term
| 1st at the site of infection |
|
Definition
|
|
Term
|
Definition
|
|
Term
| granules contain lysosomes |
|
Definition
|
|
Term
| secrete antimicrobial chemicals |
|
Definition
|
|
Term
| line mucous membranes or respiratory, GI and urinary tract |
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Definition
|
|
Term
| increases during an allergic reaction and in a parasitic |
|
Definition
|
|
Term
| release enzymes to destroy parasites such as worms |
|
Definition
|
|
Term
| phagocytizes inflammatory chemicals and antigen-antibody complexes and allergens |
|
Definition
|
|
Term
|
Definition
|
|
Term
| secrete histamine/heparin |
|
Definition
|
|
Term
| vasodilator and makes BV leaky |
|
Definition
|
|
Term
| anticoagulant that inhibits blood clotting and increases mobility of other WBCs in the area |
|
Definition
|
|
Term
|
Definition
|
|
Term
| second to neutrophil in abundance |
|
Definition
|
|
Term
|
Definition
| destroy cancer cells, virus infected cells, foreign cells, present antigens, coordinate actions of other immune cells, secrete antibodies, serve in immune memory |
|
|
Term
| differentiate in bone marrow |
|
Definition
|
|
Term
|
Definition
|
|
Term
| convert into plasma cells and secrete antibodies against pathogens |
|
Definition
|
|
Term
| set up the pathogen for destruction |
|
Definition
|
|
Term
| stimulate or inhibit other lymphocytes |
|
Definition
helper T-cell suppressor T-cell |
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|
Term
| kill virus infected cells, tumor cell, foreign cells, transplanted cells |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| levels increase during inflammation and viral infections |
|
Definition
|
|
Term
| once monocyte leaves BV, they are called |
|
Definition
|
|
Term
|
Definition
|
|
Term
| destroy dead or dying host and foreign cells, pathogenic chemicals and pathogenic microbes by phagocytosis |
|
Definition
|
|
Term
| "present" antigens to activate other cell of the immune system aka antigen presenting cells APC |
|
Definition
|
|
Term
|
Definition
|
|
Term
| bacterial infection triggers production of |
|
Definition
|
|
Term
| allergy triggers production of |
|
Definition
|
|
Term
| both B- and T-lymphocytes colonize in |
|
Definition
| spleen lymph nodes lymphoid organs and tissues |
|
|
Term
| true/false circulating WBCs stay in bloodstream |
|
Definition
|
|
Term
|
Definition
leukemia myeloid leukemia lymphoid leukemia |
|
|
Term
| cancer of hemopoietic tissue that produces high numbers of circulating leukocytes |
|
Definition
|
|
Term
| uncontrolled granulocyte production |
|
Definition
|
|
Term
| uncontrolled lymphocyte or monocyte production |
|
Definition
|
|
Term
| what is the control of bleeding |
|
Definition
|
|
Term
|
Definition
|
|
Term
| mechanism for stopping leaks which could be potentially fatal |
|
Definition
|
|
Term
| platelets originate from... |
|
Definition
|
|
Term
| cell fragments that lack nucleus |
|
Definition
|
|
Term
|
Definition
1 secrete vasoconstrictors that stimulate spasmodic constriction of broken BV to reduce blood loss 2 stick together to form temp platelet plugs to seal small breaks in BV 3 secrete procoagulants or clotting factors 4 initiate formation of clot-dissolving enzyme 5 secrete chem to attract neutrophils and monocytes to sites of inflammation 6 internalize and destroy bacteria 7 secrete growth factors to stimulate fibroblast and SM to repair BV |
|
|
Term
| what is platelet production |
|
Definition
|
|
Term
| ___ stem cells produce receptors for hormone ___ and ___ are produced |
|
Definition
hemopoietic thrombopoietin megakaryocytes |
|
|
Term
| ? break up into platelets |
|
Definition
|
|
Term
| what are stored in the spleen and released when needed |
|
Definition
|
|
Term
|
Definition
vascular spasm platelet plug formation blood coagulation |
|
|
Term
| prompt constriction of a broken vessel |
|
Definition
|
|
Term
| during vascular spasm platelets release |
|
Definition
|
|
Term
| a chemical vasoconstrictor |
|
Definition
|
|
Term
|
Definition
|
|
Term
| significantly reduces blood loss and provides time for other 2 hemostatic mechanisms to work |
|
Definition
|
|
Term
|
Definition
|
|
Term
| may reduce or stop minor bleeding |
|
Definition
|
|
Term
| during platelet plug formation platelets release |
|
Definition
|
|
Term
| an eicosanoid that promotes platelet plug formation and vasoconstriction |
|
Definition
|
|
Term
| what inhibits thromboxane A2 |
|
Definition
|
|
Term
|
Definition
|
|
Term
| most effective defense against bleeding |
|
Definition
|
|
Term
| true/false it is important for blood not to clot in an unbroken blood vessel |
|
Definition
|
|
Term
| in coagulation, the objective is to convert ___ into ___ |
|
Definition
fibrinogen insoluble fibrin |
|
|
Term
| a sticky protein that adheres to BV wall |
|
Definition
|
|
Term
| blood cells and platelets stick to ___ resulting in a mass that seals the BV |
|
Definition
|
|
Term
|
Definition
| procoagulants produced by liver |
|
|
Term
| when one clotting factor is activated, it functions as an ___ that activates the next clotting factor |
|
Definition
|
|
Term
| clotting factors activate one factor and that factor will activate the next to form a |
|
Definition
|
|
Term
| the last four procoagulants |
|
Definition
|
|
Term
| nutrients needed for coagulation |
|
Definition
calcium vitamin k clotting factors |
|
|
Term
| necessary substances for blood to clot |
|
Definition
|
|
Term
| cofactor for clotting factors |
|
Definition
|
|
Term
| needed for the production of clotting factors in the liver |
|
Definition
|
|
Term
| after the blood clot has formed, platelets adhere to fibrin and contract; platelets pull fibrin like drawstring on purse in a process called |
|
Definition
|
|
Term
| platelets and endothelial cells secrete |
|
Definition
| platelet-derived growth factor PDGF |
|
|
Term
| platelet-derived growth factor PDGF stimulates |
|
Definition
| fibroblast and smooth mus cells to multiply and repair BV |
|
|
Term
| once BV repaired, the clot must be |
|
Definition
|
|
Term
|
Definition
|
|
Term
| tissue plasminogen activator TPA |
|
Definition
converts plasminogen to plasmin TPA = kallikrein |
|
|
Term
| a fribin-dissolving enzyme that breaks up the clot |
|
Definition
|
|
Term
| is plasmin a anticoagulant |
|
Definition
|
|
Term
| true/false in platelet replulsion, platelets do not adhere to the smooth prostacyclin-coated endothelium of healthy BV |
|
Definition
|
|
Term
| in dilution, small amts of ___ formed spontaneously in plasma |
|
Definition
|
|
Term
| decrease in blood flow causes... |
|
Definition
thrombin to accumulate and clotting can occur can occur in cirvulatory shock |
|
|
Term
| inhibited by anticoagulants in the plasma |
|
Definition
|
|
Term
| secreted by liver that deactivates thrombin |
|
Definition
|
|
Term
| anticoagulant secreted by basophils and mast cells |
|
Definition
|
|
Term
| blocks action of thrombin |
|
Definition
|
|
Term
| given by injection to patients with abnormal clotting tendencies |
|
Definition
|
|
Term
| examples of anticoagulants |
|
Definition
plasmin antithrombin heparin |
|
|
Term
| examples of vitamin K antagonist |
|
Definition
|
|
Term
| extract of sweet clover, tonka beans |
|
Definition
|
|
Term
|
Definition
|
|
Term
| suppresses formation of eicosanoid thromboxane, factor in platelet aggregation |
|
Definition
|
|
Term
| secrete hirudin that inhibits thrombin |
|
Definition
|
|
Term
| organ that synthesizes most of the clotting factors |
|
Definition
|
|
Term
| liver requires what vitamin for synthesis of clotting factors |
|
Definition
|
|
Term
| manufactors and secretes bile which is necessary for the absorption of vitamin k |
|
Definition
|
|
Term
| can obstruct secretion of bile and result in vitamin k not being absorbed in intestines |
|
Definition
|
|
Term
|
Definition
|
|
Term
| thrombus that breaks away, floats in bloodstream and may lodge elsewhere |
|
Definition
|
|
Term
| tissue death may occur brain, heart, lungs |
|
Definition
|
|
Term
| widespread clotting within unbroken BVs |
|
Definition
| disseminated intravascular coagulation DIC |
|
|
Term
| DIC is usually triggered by |
|
Definition
|
|
Term
| bacteria in the bloodstream |
|
Definition
|
|
Term
| marked by widespread hemorrhaging, congestion of BV with clotted blood, and tissue necrosis in blood deprived organs |
|
Definition
| disseminated intravascular coagulation DIC |
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immunoglobulins antibodies |
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| 3 main contributors to blood osmolarity |
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sodium ions proteins (albumins) RBC's |
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| another name for antigens |
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| nutritional requirements for RBC production |
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| -emia on the end of the word means its dealing with what |
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| during RBC production, ___ become mature RBC (erythrocyte) |
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| macrophages in the ___ & ___ phagocytize worn out RBC |
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| during hemolysis, what can happen if the HGB is not disposed of completely? |
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| HGB can block kidney tubules and lead to renal failure |
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| macrophages convert heme into |
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| bilirubin is released from macrophage to ___ in the blood |
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| ___ removes bilirubin from albumin and secretes it into the bile. (organ) |
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| gut bacteria converts bilirubin into ___ responsible for feces brown color |
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| basophils try to do what to infection |
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| ___ count increases during allergic reaction |
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| WBC that phagocytizes inflammatory chemicals |
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| what are antigen presenting cells known as |
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| platelets originate from what huge cell |
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| what breaks RBC up into platelets |
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| where are platelets stored til they are needed |
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| what vitamin is needed for production of clotting factors in the liver |
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