Zocor

Simvastatin

dose 10-40 mg/day

DDI's  increases warfarin, digoxin,

CYP3A4 inh. inc. statin []

CYP 3A4 inhibitors

itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, nefazodone, and grapefruit juice

(these may cause rhabdo if used with some statins)

Crestor

rosuvastatin

dose 5-40 mg/day

DDI's  cyclosprorine inc crestor [] by 11x

not CYP3A4 metabolized

Pravachol

Pravastatin

10-40mg at bedtime

DDI's  gemfibrozil, nicotinic acid, erythromycin, or immunosuppressive agents inc rhabdo

not CYP3A4 metabolized

Lovaza

omega-3-acid ethyl esters

4g/day

to dec. TG

dont use if allergic to fish

(omega 3 fish oils)

Niaspan

Niacin (ER)

start w/ 500 mg QHS x 4 wks with snack

contraindicated in hepatic dysfunction, active peptic ulcer disease, or arterial bleeding

LFT tests required

increased risk of rabdo w/ statin use

Mevacor

Lovastatin

20-40mg/day

CYP 3A4 metabolizm

gemfibrozil = myopathy

take with dinner

Lopid

Gemfibrozil

(the gem is not a gem = worse for rhabdo)

600mg BID ac

DDI's lovastatin = rhabdo 

contraindicated in renal dysfunction and gallbladdre disease, may cause cholelithiasis

Tricor

Fenofibrate

145 mg/day with meals

increases rhabdo risk w/ statins

warfarin DDI inc bleeding

contraindicated with hapatic or severe renal dysfunction, biiary cirrhosis, liver dysfuntion, gallblader dx

may lead to gallstones

vytorin

Ezetimibe with simvastatin

10/20 QD

ezetimibe dec. absorption of cholesterol

DDI's gem and feno = inc []

CYP3A4 inhibitors inc. rhabdo risks

contraindicated active liver dx

(all statins contraindicated in prego)

Zetia

Ezetimibe

10mg/day

gem and feno = inc []

cholestyramine = dec []

ADV = myalgia, inc VPDD, hepatitis, thrombocytopenia, rhabdo

Lipitor

Atorvastatin

10-80mg/day given at anytime of day (most statins are taken QHS)

CYP3A4 metabolized

contraindicated in prego/nursing, liver dx

Provigil

Modafinil

200mg QAM

narcolepsy and other sleep disorders

Byetta

Exenatide

injection 5mcg SQ BID 60 min AC

GLP-1 like

secretagogue only in presence of glucose, slows GI emptying,

avoid giving with meds requiring rapid absorption

Januvia

Sitagliptin

100mg/day

DDP4 inhib (=inc glp-1)

decreases hepatic glucose production, delays GI emptying, increases ins secretion in presence of glucose.

not much in DDI's

take w/o regard to meals

Glucotrol, and Glucotrol XL

Glipizide

5-20mg/day

secreatagogue

alcohol inc effects of Glocotrol = hypoglycemia

take 30min AC

Amaryl

Glimepiride

1-4mg/day max 8mg/day

secreatagogue

take with brkfst

hypoglycemia

Micronase or Diabeta

glyburide

2.5-5mg once or twice/day

secreatagogue

Glucovance

glyburide with metformin

2.5mg/500mg or 5mg/500mg BID AC

contraindicated with impaird renal function

srcr 1.5 men 1.4 wm

diarrhea, HA N/V, abfominal pain, upper resp inf.

Avandia

Rosiglitazone

4-8mg/day

thiazolidinedione that improves ins sensitivity (PPAR, agonist)  requires ins for activity,

RISK of MI inc w/ insulin or nitrate  contraindicated in typ1dm  or pts with HF, may inc risk of getting prego if not using BC, RISK of macular edema (eye exams needed) 

take w/or w/o food