Term
| What is the product of CoA and ATP? |
|
Definition
|
|
Term
| Fatty acids differ in what? |
|
Definition
|
|
Term
| Where are fatty acids degraded? |
|
Definition
|
|
Term
| Acetyle CoA cannot get through what? |
|
Definition
| Inner membrane of mitochondria |
|
|
Term
| What shuttles the CoA through the inner membrane of mitochondria? |
|
Definition
|
|
Term
| What is the name of the three enzymes that works in the shuttle? |
|
Definition
| Carnitine Palmitoyl Transferases |
|
|
Term
| We combine fatty acid and what? |
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Definition
|
|
Term
| What catalyzes the bonding of acey coA to carnitine? |
|
Definition
| carnitine palmitoyl transferase I |
|
|
Term
| Carnitineaylcarnitine translocase does what? |
|
Definition
| gets it into the mitochondria |
|
|
Term
| Carnitine bonds with hydroxyl group to give what? |
|
Definition
| aceyl coA ready for beta oxidation |
|
|
Term
|
Definition
| drops the carnitine to get the fatty acid back for beta oxidation |
|
|
Term
| What is OH replaced by in the matrix? |
|
Definition
|
|
Term
| Malonlyl CoA is the precurser for what? |
|
Definition
|
|
Term
| A lot of acetyl coA means what? |
|
Definition
|
|
Term
| A lot of acetyl coA produces what? |
|
Definition
|
|
Term
| Malonyl coA inhibits what? |
|
Definition
| carnitie palmitoyl Transferase I. |
|
|
Term
| Oxidation occurs at what? |
|
Definition
|
|
Term
| What do we breakdown our fats into? |
|
Definition
Acetyle CoA- krebs
FADH2 and NADH- oxidative phosph. to create ATP |
|
|
Term
| How many carbons are broken at a time? |
|
Definition
|
|
Term
| What is the only regulatory mechanism? |
|
Definition
| hormone lipase in adipose tissue |
|
|
Term
| Our fist product is produced from what enzyme? |
|
Definition
|
|
Term
| Second reaction is what type? |
|
Definition
|
|
Term
| What is the product from step one? |
|
Definition
|
|
Term
| What is the product in step three? |
|
Definition
|
|
Term
| What is the enzyme in step 4 that cleaves SH? |
|
Definition
|
|
Term
| What is the last product in step 4? |
|
Definition
| acetyl CoA and a shortened fatty acyl coA that is 2 carbons shorter |
|
|
Term
| Where does the acetyl coA and aceyl coA go? |
|
Definition
| acetyl goes to krebs and aceyl goes to another round of beta oxidation |
|
|
Term
| What does round one of beta oxidation start with? |
|
Definition
| Fatty acyl CoA, FAD, NAD, HS-CoA |
|
|
Term
| What do we get from beta oxidation? |
|
Definition
| fatty acyl CoA (2 carbons less), FADH2, NADH, acetyl CoA |
|
|
Term
| If we start with an even number chain of fatty acids, what happens in the last round of beta oxidation? |
|
Definition
| you get butyryl CoA which is converted to 2 acetyl CoA |
|
|
Term
| What is the product of beta oxidation if we start beta oxidation with an even number of chains? |
|
Definition
|
|
Term
| What do we get if we start with 16 carbon chain? |
|
Definition
1. 7 acetyle coA + 2 acetyl coA
2. 7 FADH2
3. 7 NADH + H |
|
|
Term
|
Definition
1. 7 acetyl coA + 1 acetyl CoA + 1 succinyl CoA
2. 7 NADH + H
3. 7 FADH2 |
|
|
Term
| What is the difference in the product of beta oxidation if you start with odd number of carbon chain instead of even? |
|
Definition
1 acetyl coA and 1 Succinyl CoA in odd,
2 acetyl coA in even |
|
|
Term
| Where does beta oxid. of a very long chain of fatty acids occur? |
|
Definition
|
|
Term
| What is produced from a very long chain in peroxisomes? |
|
Definition
|
|
Term
| Long chains get degraded in _____________ into short chains which then go to ______________. |
|
Definition
| peroxisomes, mitochondria |
|
|
Term
| During fasting what is depleted in the liver? |
|
Definition
|
|
Term
| What causes oxaloacetate to be depleted during fasting? |
|
Definition
|
|
Term
| What impedes the entry of acetyl CoA into krebs? |
|
Definition
| lack of oxaloacetate while fasting due to gluconeogenesis |
|
|
Term
| What are the three major ketones? |
|
Definition
1. acetoacetate
2. converts to acetone
3. beta hydroxybutyrate |
|
|
Term
| Ketone bodies can be converted to what? |
|
Definition
| acetyl CoA for catabolism in krebs |
|
|
Term
| What causes the conversion of ketones back to acetyl coA? |
|
Definition
|
|
Term
|
Definition
| reverse the last step in beta oxid |
|
|
Term
| HMG CoA synthase catalyzes condensation of acetyl CoA + acetoacetyl CoA to form ? |
|
Definition
|
|
Term
| HMG CoA lyase cleaves HMG coA to yeild? |
|
Definition
| acetyle CoA and the ketone acetoacetate |
|
|
Term
| Saturation depends on what? |
|
Definition
| the number of double bonds |
|
|
Term
| fatty acids have to be what? |
|
Definition
| charged before entering beta oxid |
|
|
Term
| The carnitine shuttle is made up of? |
|
Definition
| CPTI and II, an carnitine-acylcarnitine translocase |
|
|
Term
| For every carnitine and fatty acid that comes in what goes out? |
|
Definition
|
|
Term
| Beta oxidation is primarily controlled by what? |
|
Definition
|
|
Term
| If you have a lot of acetyl coA you have what? |
|
Definition
|
|
Term
| A lot of malonyl coA does what? |
|
Definition
| keeps acetly coA from entering mitochondria |
|
|
Term
| What are the products of beta oxid? |
|
Definition
1. FADH2
2. NOTHING
3. NADH
4. acetyle CoA and shortened fatty acid |
|
|
Term
| No oxaloactetate no what? |
|
Definition
|
|
Term
| ketone acidosis decreaseas/increases pH? |
|
Definition
|
|
Term
| Too many ketones, breath a lot. |
|
Definition
|
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