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BE310 Exam 2
Ch. 6, 7, 8
183
Physiology
Undergraduate 3
10/10/2011

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Term
visceral afferent
Definition
incoming pathway for info derived from internal viscera (organs in body cavities)
Term
sensory afferent
Definition
incoming pathway for sensory info
Term
somatic sensation
Definition
arising from the surface
Term
somesthetic sensation
Definition
skin
Term
propioception senssation
Definition
muscles, joint, inner ear
Term
special senses
Definition
vision, hearing, taste, smell
Term
perception
Definition
conscious interpretation of the external world as created by the brain from a pattern of nerve impulses delivered to it from sensory receptors
Term
stimulus
Definition
change detectable to body
Term
modalities
Definition
energy forms of stimuli (heat, light, sound, pressure, chemical changes)
Term
receptors
Definition
respond to stimuli of environment (peripheral end afferent neurons)
Term
transduction
Definition
energy conversion process from stimuli to electrical signal
Term
adequate stimulus
Definition
stimulus that receptor is specialized for (responds more readily to)
Term
photoreceptors
Definition
visible wavelengths of light
Term
mechanoreceptors
Definition
mechanical energy
Term
thermorecptors
Definition
heat/cold
Term
osmoreceptors
Definition
changes in concentration of solutes in body fluids and resultant changes in osmotic activity
Term
chemoreceptors
Definition
specific chemicals
Term
nociciptors
Definition
pain receptors; tissue damage/distortion
Term
receptor potential (RP)
Definition
local depolarizing change in the specialized ending of afferent neuron
Term
generator potential (GP)
Definition
local depolarizing change in separate cell closely associated with peripheral ending of neuron
Term
adaptation
Definition
a phenomenon where receptors can diminish extent of depolarization despite sustained stimulus strength (AP freq. decreases)
Term
tonic receptor
Definition
do not adapt at all or adapt slowly; valuable to maintain stimulus info (i.e. muscle stretch, join propioceptors -- posture and balance)
Term
phasic receptor
Definition
rapidly adapting receptors; stops responding to maintained stimulus; allows relay of important info, no all info --> intensity, not status quo (i.e. tactile/touch receptors -- rings, clothes)
Term
off response
Definition
slight depolarization of phasic receptor when stimulus is removed
Term
pacinian corpuscle
Definition
rapidly adapting skin receptor that detects pressure & vibration
Term
somatosensory pathway
Definition
pathways conveying conscious somatic sensation consisting of discrete chains of neurons synaptically interconnected in a particular sequence to accomplish progressively more sophisticated processing of sensory info
Term
first-order sensory neuron
Definition
afferent neuron with peripheral receptor initial detection of stimulus
Term
second-order sensory neuron
Definition
first-order synapses onto it; spinal cord, medulla
Term
third-order sensory neuron
Definition
second-order synapses onto it; thalamus
Term
labeled lines
Definition
separate different types of input between periphery and cortex
Term
phantom pain
Definition
activation of sensory pathway at any point, same sensation produced by stimulation receptors in body itself
Term
receptive field
Definition
circumscribed region of skin surface surrounding response of somatosensory neuron to stimulus
Term
acuity
Definition
discrimitive ability; smaller receptive field leads to higher acuity
Term
lateral inhibition
Definition
influences acuity; most -- touch, vision -- most accurate localization
Term
pain
Definition
protective mechanism meant to bring to conscious awareness the fact that tissue damage is occurring/about to occur
Term
mechanical nociceptors
Definition
respond to mechanical damage
Term
thermal nociceptors
Definition
respond to extreme temperatures
Term
polymodal nociceptors
Definition
respond equally to ALL damaging stimuli
Term
A-delta fibers
Definition
fast pain pathway; small, myelinated, carry mechanical and thermal nociceptors at 30 m/s
Term
C fibers
Definition
slow pain pathway; small, unmyelinated, carry polymodal nociceptors at 12 m/s
Term
bradykinin
Definition
activated by enzymes released to ECF from damaged tissue, provoke pain and inflammation
Term
capsaicin
Definition
activates C fibers
Term
substance P
Definition
pain neurotransmitter, activates ascending pathways that transmit nociceptive signals to higher levels for further processing
Term
glutamate
Definition
neurotransmitter released from primary afferent pain terminals; excitatory
Term
analgesic system
Definition
suppresses transmission in the pain pathways as they enter the spinal cord (descending)
Term
endogenous opiates
Definition
anagesic neurotransmitters, released from descending analgesic pathways and bind to opiate receptors on afferent pain-fiber terminal; suppress release of substance P
Term
eyelids
Definition
shutters to protect anterior portion of eye from environment
Term
eyelashes
Definition
trap fine, airborne debris to protect eye
Term
eye
Definition
spherical fluid-filled structure
Term
sclera
Definition
tough outer layer of connective tissue covering eyeball
Term
eyeball
Definition
white of the eye
Term
cornea
Definition
outer layer of sclera, transparent, light rays pass through to enter interior of eye
Term
choroid
Definition
middle layer, pigmented (absorbs light), contains blood vessels that nourish retina
Term
ciliary body
Definition
contain capillary network that produces aqueous humor --> drains into canal at edge of cornea and enters blood
Term
suspensory ligaments
Definition
attach lens to the ciliary muscle
Term
ciliary muscle
Definition
anterior specialization of choroid layer; circular ring of smooth muscle attached to the lens
Term
iris
Definition
thin, pigmented (eye color), smooth muscle that forms visible ringlike structure in aqueous humor; iris patterns = best identification technique
Term
retina
Definition
innermost coat under choroid, consists of outer pigmented layer (absorbs light) and inner nervous tissue layer (w/ rods and cones)
Term
lens
Definition
separates 2 fluid-filled cavities in eye; elliptical, transparent
Term
vitreous humor
Definition
larger posterior cavity btwen lens/retina containing semifluid substance; maintains spherical eye shape
Term
aqueous humor
Definition
anterior cavity btwn cornea/lens, clear watery fluid; carries nutrients for cornea/lens (no blood supply)
Term
glaucoma
Definition
increased pressure (more production than drainage of aq. humor) build up in anterior cavity; pushes lens into vitreous humor; pushes against neural layer retina; nerve damage
Term
pupil
Definition
round opening in center of iris through which light enter interior portions of eye; size adjusted by variable contraction of iris muscles for light control
Term
circular/constrictor muscle
Definition
muscle fibers circular, parasympathetic (bright light --> smaller pupil)
Term
radial/dilator muscle
Definition
fibers project outward from pupil, sympathetic (dim light --> bigger pupil)
Term
light
Definition
form of electromagnetic radiation com,posed of photons
Term
photons
Definition
wave travel, packets of energy
Term
wavelength
Definition
distance between 2 wave peaks
Term
light ray
Definition
forward mvmt of light wave in particular direction (radiate all directions from source)
Term
focal point
Definition
point at which divergent light rays are focused, from bending inward
Term
refraction
Definition
bending of light (greater curvature, greater bending, stronger lens)
Term
conVEX
Definition
curves outward (i.e. ball); converges light rays to focal pt
Term
conCAVE
Definition
curves inward (i.e. cave); diverges light rays (correct nearsightedness)
Term
astigmatism
Definition
curvature of cornea is uneven which leads to unequal refraction
Term
accommodation
Definition
ability to adjust strength of lens
Term
presbyopia
Definition
age-related reduction in accommodative ability
Term
cataract
Definition
condition when elastic lens fibers become opaque and prevent light rays from passing
Term
emmetropia
Definition
normal eye, far light source focused on retina w/o accommodation, whereas strength of lens increased by accommodation to bring near source into focus
Term
myopia
Definition
eye too long/lens to strong; near light focuses on retina w/o accommodation, whereas far light source focused in front of retina is blurry (nearsighted -- concave to correction)
Term
hyperopia
Definition
eye too short/lens too week; far objects focus w/o accommodation; whereas near objects focused behind retina area (far sighted, convex correction)
Term
neural excitable layers
Definition
outermost: rods and cones (light sensitive, face away from incoming light)
middle: bipolar cells
inner: ganglion cells (axons of which form optic nerve); optic disk (pt on retina where optic nerve leaves and blood vessels pass, aka blind spot)
Term
fovia
Definition
pinhead-sized depression at center of retina where bipolar and ganglion cell layers are pulled aside so light strikes photorecptors directly; only cones (acuity) --> direct focus
Term
macula lutea
Definition
area surrounding fovia, high cone concentration but less acuity than fovia -- overlying ganglion and bipolar cells
Term
macular degeneration
Definition
loss of photoreceptors in macula lutea when older "donut vision"
Term
photoreceptors
Definition
rods and cones
Term
photopigment
Definition
chemically altered by light (three types: red, green, and blue)
Term
opsin
Definition
protein in disk membrane
Term
retinene
Definition
bound inside opsin -- absorbs light (Vitamin A)
Term
rhodopsin
Definition
rod, absorbs all visisble
Term
phototransduction
Definition
the process of converting light stimuli into electrical signals
Term
transducin
Definition
rod and cone cell's G protein for secondary messenger pathway
Term
cones
Definition
gnerally has a private line connecting it to a particular ganlion cell; highly detailed vision b/c private line and small receptive field
Term
rods
Definition
many that converge via bipolar cells on a single ganglion; good for summation; more sensitive because APs with small amt of light
Term
dark adaptation
Definition
breakdown of photopigments during exposure to sunlight; decreases photoreceptor sensitivity
Term
light adaptation
Definition
photopigments are rapidly broken down by the intense light, the sensitivity of the eyes decreases
Term
color blindness
Definition
lack a particular cone type
Term
visual field
Definition
what you can see without moving your head
Term
binocular field of vision
Definition
overlapping area seen by both eyes at the same time
Term
simple cells
Definition
stacked on top of one another within the cortical columns of the PVC; fire only when a bar is viewed vertically/horizontally/obliquely in specific location
Term
complex cells
Definition
stacked on top of one another within the cortical column of PVC; movement of critical axis of orientation
Term
hypercomplex cells
Definition
found in the higher visual processing areas; responding only to particular edges, corners, and curves
Term
sound waves
Definition
consist of alternate regions of compression and rarefaction of air molecules
Term
external ear
Definition
role in sound localization
Term
tympanic membrane
Definition
vibrates in unison with sound waves in the external ear
Term
middle ear bones
Definition
convert tympanic membrane vibrations into fluid movements in the inner ear
Term
cochlea
Definition
contains the organ of Corti, the sense organ for hearing
Term
hair cells
Definition
in organ of Corti, transduce fluid movements into neural signals
Term
pitch discrimination
Definition
depends on the region of the basilar membrane that vibrates
Term
loudness discrimination
Definition
depends on the amplitude of vibration
Term
auditory cortex
Definition
mapped according to tone
Term
deafness
Definition
caused by defects either in conduction or neural processing of sound waves
Term
vestibular apparatus
Definition
important for equilibrium by detecting position and motion of head
Term
semicircular canals
Definition
Term
otolith organs
Definition
Term
taste receptor cells
Definition
located primarily within tongue taste buds
Term
taste discrimination
Definition
coded by patterns of activity in various taste bud receptors
Term
olfactory receptors
Definition
in the nose, are specialized endings of renewable afferent neurons
Term
vomeronasal organ
Definition
detects pheromones
Term
autonomic nervous system
Definition
involuntary (cardiac muscle, smooth muscle, most exocrine glands)
Term
somatic nervous system
Definition
voluntary (skeletal muscle)
Term
terminal ganglia
Definition
very close to the effector organ
Term
adrenal medulla
Definition
modified sympathetic ganglion does to give rise to postganglionic fibers; secretes directly into the blood vessels; reinforces activity of the sympathetic nervous system
Term
nicotinic receptors
Definition
activated by the tobacco plant derivative nicotine, found on autonomic ganglia
Term
muscarinic receptors
Definition
activated by the mushroom poison muscarine; found in effector cell membranes (smooth, cardiac and gland), 5 subtypes of receptors, linked with G proteins
Term
cholinergic receptors
Definition
(nicotinic and muscarinic) binding of the AcH opens cation channels in the postganglionic cell, permits passage of Na+ and K+ ions
Term
adrenergic receptors
Definition
receptors for norepinephrine and epinephrine
Term
alpha adrenergic receptor
Definition
norepinephrine, alpha1 = elicits response via the Ca2+ 2nd messenger system (excitatory response); alpha2 blocks cyclic AMP production (inhibitory response)
Term
beta adrenergic receptors
Definition
beta1 equal affinity for nor/epinephrine, found in heart, excitatory response; beta2 epinephrine, inhibitory response
Term
agonists
Definition
bind to the same receptor as the neurotransmitter and elicit an effect that mimics that of the transmitter
Term
antagonists
Definition
bind with the receptor and block the neurotransmitter response
Term
motor neurons
Definition
axons constitute the somatic nervous system
Term
neuromuscular junction
Definition
a junction of motor neuron and a skeletal muscle
Term
muscle fiber
Definition
single muscle cell
Term
terminal button
Definition
axon terminal is enlarge into a knoblike structure
Term
motor end plate
Definition
specialized portion of the muscle cell membrane immediately under the terminal button
Term
fig 7.6 on page 245
Definition
Term
end plate potential
Definition
graded potential except larger
Term
acetylcholinestrerase
Definition
by destroying acetylcholine, controls muscle activity so its not always active
Term
cardiac muscle
Definition
striated, involuntary, found only in the heart
Term
skeletal
Definition
striated, voluntary, makes up muscular system
Term
smooth muscle
Definition
unstriated, involuntary, hollow organs and tubes
Term
voluntary
Definition
can be consciously controlled, but it can also have subconscious, involuntary regulation (i.e. related to posture, balance, and stereotypical movements)
Term
myoblasts
Definition
embryonic development the huge skeletal muscle fibers, many nuclei in a single cell, abundance of mitochondria, energy-generating organelles
Term
myofibril
Definition
a specialized intracellular structure for skeletal muscle
Term
A band
Definition
dark, made up of stacked set of think filaments along with the portions o the thin filaments that overlap both ends of the thick filaments, all of the thick filaments is included and half of the thin
Term
H zone
Definition
the lighter are within the middle of the A band where the think filaments do not reach
Term
M line
Definition
supporting protiens that hold the thick filaments vertically, middle o fA band with the center of the H zone
Term
I band
Definition
light, remaining portion of the thin filaments
Term
Z line
Definition
dark dense line down the I band, cytoskeletal disc that connects the thin filaments of two adjoining sarcomeres
Term
sarcomere
Definition
area between two Z lines, functional unit of skeletal muscle
Term
titin
Definition
extend in both directions from the M line along the length of the thick filament to the Z lines at opposite ends of the sarcomere
Term
cross bridge
Definition
extending from each thick filament towards the surrounding thing filaments in the areas where the thick and thin filaments overlap (arranged hxagonally)
Term
myosin
Definition
protein consisting of two identical subunits each shaped somewhat like a golf club in the head of myosin, there is an actin binding site and myosin ATPase site (contractile protein)
Term
actin
Definition
main structural component of the thin filaments; spherical, backbone of the thin filament, formed by two strand of actin molecules, contractile protein
Term
tropomyosin
Definition
threadlike proteins that lie end to end alongside the groove of the actin spiral, cover the actin sites that bind with cross bridges, blockind the interaction that leads to muscle contraction
Term
troponin
Definition
made of three polypeptide units, one binds to tropomyosin, one to actin and third with Ca2+
Term
sliding filament mechanism
Definition
thin filaments on each side of a sarcomere slide inward over the stationary thick filaments toward A band's center during contraction; puoll Z lines closer, shortening sarcomere;
Term
power stroke
Definition
pulling the thin filament inward, repeated cycles of cross bridge binding and bending complete shortening
Term
excitation-contraction coupling
Definition
refers to the series of events linking muscle excitation to muscle contraction
Term
Transverse tubule (t tubule)
Definition
junction of A band and I band where it runs perpendicular from the surface of the muscle cell membrane into the central portions of the muscle fiber
Term
latent period
Definition
time delay of a few msec btwn stimulation and onset of contraction
Term
contraction time
Definition
from contraction onset until peak tension develops; doesn't end until the lateral sacs have taken up all the Ca2+ released
Term
relaxation time
Definition
time from peak tension until relaxation is complete
Term
tendons
Definition
attache the muscle to bone
Term
twitch
Definition
a single AP in a muscle fiber that produces a brief, weak contraction
Term
factors to accomplish gradation of whole-muscle tension
Definition
number of muscle fibers contracting within a muscle and tension developed by each contracting fiber
Term
motor unit
Definition
motor neuron along with all the muscle fibers it innervates
Term
motor unit recruitment
Definition
stronger contractions have more motor units stimulated
Term
fatigue
Definition
inability to maintain muscle tension at a given level
Term
asynchronous excitation
Definition
alternation between motor units
Term
twitch summation
Definition
muscle fiber is re stimulated before it has completely relaxed, the second twitch is added to the first
Term
tetatnus
Definition
muscle fiber stimulated repeatedly without relaxation between stimulation, maximal sustained contraction, strong than a single twitch
Term
isotonic contraction
Definition
muscle tension remains constant as the muscle changes length; for body movements and external objects
Term
concentric
Definition
muscle shortens --> velocity decreases as load increases
Term
eccentric
Definition
muscle lengths --> load and velocity directly related
Term
isometric contraction
Definition
tension develops at constant muscle length
Term
work
Definition
force times a distance
Term
force
Definition
skeletal muscles, muscle tension required to overcome load
Term
lever
Definition
bones, rigid structure capable of moving around a pivot point (fulcrum= joints)
Term
power arm
Definition
portion of a lever between fulcrum and point where UPWARD force is applied
Term
load arm
Definition
portion of lever between fulcrum and point where DOWNWARD force is applied
Term
Pathways supplying ATP
Definition
transfer of high-E phosphate from creatine phosphate to ADP; oxidative phosphorylation (citric and ETC); glycolysis
Term
myoglobin
Definition
similar to hemoglobin and increases the rate of oxygen transfer from the blood into muscle fibers
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