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Bb- Lewis and Secretor
Test 1
16
Health Care
Undergraduate 4
06/14/2009

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Cards

Term
Which gene regulates the H gene in secretions?
Definition
Secretor.
Term
What percent of the population are secretors (Sese or SeSe)?
Definition
80 %
Term
What is the product of the Se gene?
Definition
fucosyltransferase
Term
What kind of test is done to determine secretor status?
Definition
neutralization/ hemagglutination inhibition
Term
Before doing the neutralization test for secretor status, saliva is heated. What does this heating inactivate?
Definition
enzymes
Term
What cells produce Lewis antigens?
Definition
tissue cells.
Term
Is H necessary to form Lea?
Definition
No.
Term
Is H necessary to form Leb?
Definition
Yes.
Term
What three genes are necessary to form Leb?
Definition
Le, Se, and H
Term
Does a person with Leb have Lea on the red cells? In the secretions?
Definition
A person with Leb does not have Lea on the red cells but has a small amount of Lea in the secretions.
Term
What Lewis type are newborns?
Definition
Le(a-b-)
Term
What happens to Lewis antigens during pregnancy?
Definition
They decrease; after delivery they return to normal
Term
What is the usual class of Lewis antibodies?
Definition
Usually IgM, can be IgG
Term
Can Lewis antibodies cause HDFN?
Definition
No, the fetus is Le(a-b-)
Term
Can Lewis antibodies cause transfusion reactions?
Definition
Yes, if they are hemolytic
Term
Do Le(a-b+) persons make anti-Lea?
Definition
No because of small quantities of unconverted Lea in saliva and plasma
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