Term
| Which gene regulates the H gene in secretions? |
|
Definition
|
|
Term
| What percent of the population are secretors (Sese or SeSe)? |
|
Definition
|
|
Term
| What is the product of the Se gene? |
|
Definition
|
|
Term
| What kind of test is done to determine secretor status? |
|
Definition
| neutralization/ hemagglutination inhibition |
|
|
Term
| Before doing the neutralization test for secretor status, saliva is heated. What does this heating inactivate? |
|
Definition
|
|
Term
| What cells produce Lewis antigens? |
|
Definition
|
|
Term
| Is H necessary to form Lea? |
|
Definition
|
|
Term
| Is H necessary to form Leb? |
|
Definition
|
|
Term
| What three genes are necessary to form Leb? |
|
Definition
|
|
Term
| Does a person with Leb have Lea on the red cells? In the secretions? |
|
Definition
| A person with Leb does not have Lea on the red cells but has a small amount of Lea in the secretions. |
|
|
Term
| What Lewis type are newborns? |
|
Definition
|
|
Term
| What happens to Lewis antigens during pregnancy? |
|
Definition
| They decrease; after delivery they return to normal |
|
|
Term
| What is the usual class of Lewis antibodies? |
|
Definition
|
|
Term
| Can Lewis antibodies cause HDFN? |
|
Definition
| No, the fetus is Le(a-b-) |
|
|
Term
| Can Lewis antibodies cause transfusion reactions? |
|
Definition
| Yes, if they are hemolytic |
|
|
Term
| Do Le(a-b+) persons make anti-Lea? |
|
Definition
| No because of small quantities of unconverted Lea in saliva and plasma |
|
|
