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Bb- humoral response in relation to immunohematology
test 1
17
Health Care
Undergraduate 4
06/14/2009

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Term
Any molecule that can be recognized by the adaptive immune system elements.
Definition
antigen.
Term
Small portion of the antigen that contacts the antigen-binding sites of B cell or T cell receptor.
Definition
epitope.
Term
What is an allogeneic antigen?
Definition
antigens from humans- red cells, leukocytes, platelets, or immunoglobulin antigens.
Term
What is an autologous antigen?
Definition
antigens from self- damaged or mutated, or recognized through cross-reactivity.
Term
soluble immunoglobulin synthesized by a plasma cell upon exposure to an appropriate antigen.
Definition
antibody
Term
destruction of cells within the monocyte/macrophage system is what kind of destruction?
Definition
extravascular
Term
Destruction of cells by complement is what kind of cell destruction?
Definition
intravascular
Term
What classes of antibody are human blood group antibodies usually?
Definition
IgG, IgM and occasionally IgA
Term
What is the immunoglobulin class in the primary response?
Definition
IgM.
Term
What is the usual class of antibodies formed in response to red cells, white cells and platelets?
Definition
IgG or IgM.
Term
How many subclasses are there of IgG?
Definition
Four.
Term
Which subclass of IgG does not cross the placenta?
Definition
IgG2.
Term
Which subclass of IgG activates the classical complement pathway the best?
Definition
IgG3.
Term
Which subclass of IgG does not activate complement by the classical pathway?
Definition
IgG4.
Term
Which 2 classes of IgG interact well with Fc receptors on phagocytic cells?
Definition
IgG1 and IgG3
Term
Does IgM activate complement?
Definition
Yes, IgM activates complement readily once bound to target.
Term
Does IgM cross the placenta?
Definition
No.
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