Term
| african sleeping sickness |
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Definition
melarsoprol - east - reacts with sulfhydral groups making enzymes non functional. can cause HSN, GI, neurotoxic
elfornithine - west - inhibits orthine decarboxylase. causes thrombocytopenia, seizure |
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Term
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Definition
metronidazole - dna and protein destruction
disulfram, dark urine |
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Term
| anaerobic above diaphragm |
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Definition
clindamycin - protein synthesis inhibitor
pseudomonas collitis |
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Term
| anaerobic below diaphragm |
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Definition
metronidazole - dna and protein destruction
dusulfram, dark pee |
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Term
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Definition
indomethacin - inhibits cox, precenting prostagnaldins
gastric irritation, bleeds, perforation |
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Term
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Definition
penicillin after it has been proven sensitive to it - cell wall inhibitor
possible hsn |
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Term
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Definition
ssri or tca, bdz az needed
ssri- block reuptate of se
tca - block reuptake of se and ne and muscarinic, alpha, and h1
benzo - bdz receptor agonist, increases GABA binding and Cl intake inhibiting neurons
ssri - loss of lobido, weight gain, seizure on od
tca- dry mouth, constipation, urinary retention, weight gain
benzo - drowsiness, confusion, respiratory depression |
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Term
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Definition
voriconazole doc or amphotericin
vori- ergosterol inhibitor. skin reactions, hepatotoxic, visual change, photosensitivity
amp- ergosterol inhibitor, cell membrane pore former. nephrotoxic, ototoxic |
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Term
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Definition
all need SABA usually albuterol, more meds depending on severity
stimulates b2 causing bronchodilation
can cause tachycardia |
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Term
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Definition
steroids - anti inflammatory, decreased prostaglandin, decrease T cells, decrease Ab, decrease capillary permability
fat redistribution to center, infection risk, psych disturbance |
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Term
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Definition
vancomycin or clindamycin
vanco- cell wall and membrane synthesis inhibitor, red man syndrome
clindamycin - protein synthesis inhibitor, pseudomembranous collitis |
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Term
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Definition
metronidazole - dna and protein destruction
disulfram
dark pee |
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Term
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Definition
5a reductase inhibitor - dinasteride, dutasteride, turosteride
stops conversion of testosterone to DHT so androgen stimulation to prostate is decreased
erectile dysfunction, decreased lobido, decreased ejaculatory volume |
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Term
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Definition
lithium plus mood stabilizer or atypical antipsychotic
lithium- interferes with Na movement and exchange, messes with IP3
ataxia, diabetes insipidus, seizure |
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Term
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Definition
itraconazole - ergosterol synthesis inhibitor
hepatotoxic |
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Term
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Definition
azithromycin (alt erythromycin) - protein synthesis inhibitor
qt prolongation |
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Term
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Definition
fluconazole - ergosterol synthesis inhibitor
hepatotoxic |
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Term
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Definition
nifurtiomox or benznidazole
destory enzymes by making ROS
abdominal pain, nausea, vomiting
nif - exacerbates G6PD
benz- teratogenic |
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Term
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Definition
doxy (+ceftriaxone to tx gonorrhea)
doxy - protein synthesis inhibitor, stain teeth, photosensitivity, pseudomotor cerebri
cef- cell wall lsynthesis inhibitor, hsn |
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Term
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Definition
piperacillin - cell wall synthesis inhibitor, hsn
tazo - b-lactaminase inhibitor preventing destruction of piperacillin by lactiminases |
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Term
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Definition
albuterol - b2 agonist
palpitations |
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Term
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Definition
gancyclovir and valgancyclivor - inhibit dna synthesis
marrow sypression can cause aplastic anemia |
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Term
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Definition
digitoxin - exacerbated
loops, BB, ARB - increase longevity in non-exacerbated
digoxin - inhibits n/k pump causing increase in Ca entry which increases CO on next contraction
visual change, arrhythmias |
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Term
| conjunctivitis bacterial non gonoccal or chalmydia |
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Definition
fluoroquinolone eye drops - topoisomerase inhbitior
mild discomfort |
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Term
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Definition
no rx
chilled artificial tears to soothe |
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Term
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Definition
amphotericin b and flucytosine - ergosterol antagonist, cell membrane pore former, dna synthesis inhibitor
amp- nephrotoxic, ototoxic
flu - marrow toxic |
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Term
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Definition
insulin - increases glucose uptake into fat and skeletal muscle
hypoglycemia |
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Term
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Definition
| metformin - inhibits absorption of glucose from bowel, decreases gluconeogenesis, increases glucose uptake in fat and skeletal muscle |
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Term
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Definition
cipro or levofloxacin and metronidazole
cipro/levo- topoisomerase inhibitors, cartilage damage in kids, tendon rupture iin elderly, photosensivity, cns toxicity
metro- dna and protein destruction, disulfram, dark pee |
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Term
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Definition
erythromycin and antitoxin
protein synthesis inhibitor
qt prolongation |
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Term
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Definition
metronidazole and cipro
metro- dna and protein destruction, disulfram, dark pee
cipro- topoisomerase inhibito, cartiladge damage in kids, tendon rupture in elderly, photosensitivity, cns toxicity |
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Term
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Definition
heparin - antithrombin inhibitors factors 2, 9, 10, 11, 12
hemorrhage, hypersensitivity |
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Term
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Definition
empiricaly until csf returns give acyclovir - viral dna synthesis inhibitor
nausea |
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Term
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Definition
mebendazole - prevent microtubule formation, prevent microtubule mediate glucose uptake by bug
teratogen |
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Term
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Definition
PDE5 inhibitors - inhibit phosphodiesterase decreasing degredation of cGMP in smooth muscle cells in vessels of corpus cavernosum of penis and allowing for relaxation and filling
priapism, blindness, deafness |
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Term
| fungal infection dematiaceous / black mold |
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Definition
itraconazole -erogterol synthesis inhibitor
hepatotoxic |
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Term
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Definition
acyalovir - dna synthesis inhibitor
severe hepatotoxicity |
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Term
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Definition
amphotericin b - erogeserol antagonist, cell membrane pore former
nephrotoxic, ototoxic |
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Term
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Definition
tinidazole or nitazocanide
tin- dna and protein destructive agent, disulfram
nit- inhibits ETC so no ATP made, gi problems |
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Term
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Definition
ceftriaxone (+doxy for chalmydia)
cef- cell wall synthesis inhibitor, hsn possible
doxy - protein synthesis inhibitor, staining of teeth, photosensitivity, pseudomotor cerebri |
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Term
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Definition
colchicine (after nsaid) - bind tubulin preventing wbc migration, proliferation, and release of inflammatory agents
teratogen |
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Term
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Definition
ceftriaxone or cefotaxime - life threatening
amoxicillin clavulanate - non life threatening
cell wall synthesis inhibitor
possible hsn |
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Term
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Definition
triflyridine eye drops
dna synthesis inhibitor
mild irritation |
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Term
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Definition
itraconazole
ergosterole synthesis inhibitor
hepatotoxic |
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Term
| hiv - dont do se too many |
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Definition
2 nrti + 1(nnrti, pi, inti, or ccra)
nrti- prevent dna maunfacture from viral rna by acting as nucleoside analog
nnrti - prevent dna manufacture froom viral rna by inhibitng reverse transcriptase
pi- prevent clevage and activation of major viral proteins stopping virus babies
inti- inregrase inhibitor- stops hiv dna integration into human dna
ccra- ccr5 antagonist, blocks receptors on wbc so hiv cannot bind |
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Term
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Definition
hmg-coa-reductase inhibitor, bile acid sequesterants
hmg- inhibit enzyme that controls cholesterol synthesis, causes hepatoxicity, myopathy, rhabdomyolysis
bile acid- bind cholesterol and drug into stool, causes constipation |
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Term
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Definition
thiazides - block na uptake at dct causing na and water that follows ti be lost
diuretic effect diminishes the vascular resistance decrease doesnt
hypokalemia
hypercalcemia
hyperuricemia
sulfa allergy |
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Term
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Definition
DOC radioablation with Na iodine
alt: bb, methimazole, ptu
iodine: destories gland, cannot have sex or babies for a month, could exposure family by existing at home
bb- block b1, decrease hr and co, cause bronchoconstriction, bradycardia, hypotension, erectile dysfunction
meth- inhibit thyroperoxidase stopping iodine addition to thyroglobulin, causes neutropenia, dizziness, nausea, vomiting, puritis, teratogen
ptu- inhibits 5 deiodenase and thyroperoxidase, nausea, vomiting, puritis, neutropenia, thrombocytopenia, fulminant hepatitis |
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Term
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Definition
levothyroxine- synthetic T4
palpitations, weight loss, insomnia |
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Term
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Definition
oseltamivir, zanamivie - neuraminidase inhibitor
zana- bronchospasm
both - gi prob, neuropsych stuff |
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Term
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Definition
ampicillin and gentamycin
amp- cell wall inhibitor, possible hsn
gent- protein synthesis inhibitor, ototoxicity, nephrotoxicity, neurotoxicity |
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Term
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Definition
doxycycline - protein sytnehsis inhbiitor
stains teeth
photosensitive
pseudomotor cerebri |
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Term
| major depressive disorder |
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Definition
ssri- block se reuptake
loss of lobido
weight gain
seizure with od |
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Term
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Definition
vitamin a - peds
ribavirin - adults
vit a- epithelial cell protection and restoration, possible toxicity
rib- viral transcription inhibitor, nausea |
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Term
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Definition
epiirically ceftriaxone or ceftoxamine + dexamethazone + vancomycin
cef- cell wall inhibitor, possible hsn
dexamethazone - cell wall and membrane synthesisi inhibitor, possible hyperglycemia
vancomycin - cell wall syntehsis inhibitor, red man syndrome |
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Term
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Definition
rifampin for neisseria and influenzae
rna syntheiss inhibitor of transcription
hepatotoxic
marrow toxic |
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Term
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Definition
pen g - cell wall synthesis inhibitor
possible hsn |
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Term
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Definition
aspirin + heparin + BB + nutro + morphine + O2
aspirin: platelet aggregation inhibitor, hemorrhage, hsn
heparin: anticoag inhibitor of 2, 9, 10, 11, 12, hemorrhage, possible hsn
BB: B1 block on heart decreases hr and co and O2 demand, causes bronchoconstriction, hypotension, bradycardia
nitro: venodilation, decreases preload, reduces work, high dose coronary vessel dilation which decreases afterload and work, causes hypotension
morphine: venodilation decreases preload and work, analgesic to control pain and tachycardia, anti anxiety to control tachycardia, causes respiratory depression and hypotension |
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Term
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Definition
loperamide- decreases peristalsis via opioid receptor agonism
constipation |
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Term
|
Definition
| vancomycin - cell wall and membrane synthesis inhibitor red man syndrome (erythema and htn) |
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Term
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Definition
phyostigmine or neostigmine - cholinesterase inhibitors blocking enzyme for ach degredation
increase bladder and gi motility |
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Term
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Definition
azithromycin or doxy - protien synthesisi inhibitors
azi- qt prolongation
dox- stained teeth, photosensitivity, pseudomotor cerebri |
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Term
| neuroleptic pain diabetic |
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Definition
pregabalin - inhibits ca entry into presynaptic neuron so inhibits nt release and modultes cns and gaba actions
myopathy, rhabdomyolysis, vision changes |
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Term
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Definition
gabapentin mediates gaba metabolism, reuptake, and release
sedating |
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Term
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Definition
empiric- naficillin or oxacillin - oseoclast inhibitor and apotosis inducer
heartburn, nausea, erosive gastritis, jaw osteonecrosis |
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Term
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Definition
ofloxcin drops OR (polymyxin + neomycin + hydrocortisone drops)
olfox- topoisomerase inhibitor
polymyx - disrupts bacterial cell membrane, effective against pseudomonas
neomycin - protein synthesis inhbitor
hydrocortisone - inhibits inflammation |
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Term
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Definition
iv fluids and opioids for pain control
opioids stimulate sigma to mediate pain
respiratory depression |
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Term
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Definition
dopaminergics - levodopa, pramipexole
converterd to dopamine or stimulate receptor
impulse control, sleep attack, hallucinations |
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Term
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Definition
heparin - activates at3 which inhibitors 2, 9, 10, 11, 12
hemorrhage, hsn |
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Term
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Definition
| omeprazole - proton pump inhibitor, increased gastric carcinoids |
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Term
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Definition
tmp-smx - folate synthesis inhibitor
megaloblastic anemia, nausea |
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Term
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Definition
ceftriaxone or entapenem + azithromycin in adults
cef/ert: cell wall synthesis inhibitor, hsn possible
azi- protein synthesis inhibitor, qt prolongation |
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Term
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Definition
ceftriaxone then doxycycline
cef- cell wall synthesis inhibitor, hsn possible
doxy- protein synthesis inhibitor, stain kids teeth, photosensitivity, pseudomotor cerebri |
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Term
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Definition
fluroquinolone or tmp-smx
floro- topoisomerase inhibitor, tendon rupture in old ppl, cns prob, photosensitivity
tmp- folate inhibitor, megaloblastic anemia, nausea |
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Term
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Definition
metronidazole- dna and protein destruction
disulfra, brown pee |
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Term
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Definition
voriconazole ergosterol synthesis inhibitor
skin rxn, hepatotoxic, transient visual change, photosensitivity |
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Term
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Definition
itraconazole - ergosterol synthesis inhibitor
hepatotoxic |
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Term
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Definition
ethosuxamide - decrease ca in thymus
nephrotoxic, hepatotoxic, grand mal possible |
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Term
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Definition
phenobarbitol - increases gaba via inhibitor of na/k transport
decreases cognitive performance, respiratory depression |
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Term
| seizure, generalized, tonic clonic |
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Definition
valproic acid increases cns gaba concentrationa nd activity
cns depression, hepatotoxicty, pancreatitis, drug rxns, gi issue, siadh, thrombocytopenia, SJS |
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Term
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Definition
carbamazepine - na channel blocker
marrow toxic
apleatic anemia
agranulocytosis
sjs
cardiac arrhythmia
hepatotoxic
hypothyroidism |
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Term
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Definition
azithromycin or any fouoroquinolone
azithro- protein synthesis inhibitor, qt prolongation
fuloro- topoisomerase inhibitor, cartilage damage in kids, tendon rupture in old ppl, photosensitivity, cns toxicity |
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Term
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Definition
itraconazole - ergosterol synthesis inhibitor
hepatotoxic |
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Term
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Definition
diazepam stimulates GABA receptor
sedation |
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Term
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Definition
| pen g- cell wall synthesis inhibitor, hsn possible |
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Term
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Definition
| pen g/v or benzathine pcn - cell wall synthesis inhibitors, possible hsn |
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Term
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Definition
| pen g - cell wall synthesis inhibitor possible hsn |
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Term
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Definition
| fluconazole -ergosterol synthesisi inhibitor hepatotoxic |
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Term
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Definition
propranolol
tylanol
glucocorticoids
ptu
lugol idoine 1h latrer
prop- b1 b2 blocker, hypotension, bradycardia, bronchoconstriction
tylanol- inhibits cox antupyretic, sjs possible
glycicorticoid and ptu- inhibit t4 conversion to t3, ptu also stops t4 production, ptu can cause liver failure and agranulocytosis
lugol iodine- blocks thyroid hormone release, esophageal and gastric lesions caused |
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Term
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Definition
albendazole and prednisone
alb- prevent microtibile formation and microtibule mediated glucose uptake by bug, causes teratogen, hepatotoxicity, marrow toxicity
pred- inhibitor of phospholipase a2, psych issue, increased infections |
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Term
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Definition
| metronidazole - dna and protein destructive agent, disulfram, brown pee |
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Term
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Definition
crabamazepine- na channel blocker
marrow supression, aplastic anemia, agranulocytosis, sjs, arrhythmia, heoatotoxic, hypothyroid |
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Term
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Definition
cipro or levo- topoisomerase inhibitor
cartiladge damage in kids, tendon rupture in old ppl, photosensitivity |
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Term
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Definition
tmp-smx folate inhibitor
megaloblastic anemia
nausea |
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Term
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Definition
miconazole - ergosterol synthesis inhibitor
hepatotoxic |
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