Term
|
Definition
| Decrease in RBCs or decrease in quality or quantity of Hgb |
|
|
Term
| Pernicious anemia is caused by |
|
Definition
| parietal cell destruction which leads to B12 deficiency |
|
|
Term
| Pernicious anemia affects ____ synthesis of _____ |
|
Definition
|
|
Term
| Pernicious anemia occurs most often in |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Lack of intrinsic factor leads to the inability to absorb |
|
Definition
|
|
Term
|
Definition
| sallow colored skin, sore beefy red tongue, PARATHESIAS |
|
|
Term
| Folate deficiency is required for |
|
Definition
|
|
Term
| Alcoholism and poor nutrition are the major contributors to |
|
Definition
|
|
Term
|
Definition
| chioloysis, stomatis, decreased RBC, MCV volumed elevated, homocysteine increased |
|
|
Term
| Pernicous anemia is the most _____ megablastic anemia |
|
Definition
|
|
Term
| Pernicous anemia is an __________ absence of ___________ |
|
Definition
| autoimmune and intrinsic factor |
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|
Term
| __________ is the most common type of anemia |
|
Definition
|
|
Term
| IDA is most often caused by |
|
Definition
| chronic bleeding, pregnancy*, dietary deficiency |
|
|
Term
| Chronic IDA, clinical manifestations include |
|
Definition
| brittle spoon shaped nails, sore tongue, Hgb and RBC will be low, MCV low |
|
|
Term
|
Definition
dysfx of iron uptake in RBCs
causes an increase in iron in tissues=iron overload |
|
|
Term
| What are the 3 types of sideroblastic anemia |
|
Definition
| acquired, reversible, and hereditary |
|
|
Term
| What are some reversible causes of sideroblastic anemia? |
|
Definition
| alcoholism, TB meds, copper deficiency, and hypothermia |
|
|
Term
| ___________ is impaired synthesis of alpha or beta chain Hgb A (adult Hgb) |
|
Definition
|
|
Term
| Thalessemia can be either a ________ or __________ |
|
Definition
| autosomal recessive or autosomal dominant traits |
|
|
Term
| Hgb electrophoresis determines |
|
Definition
|
|
Term
| Relative polycythemia is r/t |
|
Definition
|
|
Term
| ___________ is abnormal proliferation of bone marrow stem cells with self destruction expansion of RBCs. |
|
Definition
| Absolute (secondary) polycythemia |
|
|
Term
| Neutropenia occurs during |
|
Definition
|
|
Term
| What is a leukomoid reaction? |
|
Definition
| increase in immature leukocytes (neutrophils in particular) |
|
|
Term
| Eosinphilia occurs during |
|
Definition
|
|
Term
| Eosinopenia occurs during |
|
Definition
| stress response and drugs |
|
|
Term
| Infectius mono is an acute infection of the |
|
Definition
|
|
Term
|
Definition
|
|
Term
| B lymphocytes have __________ receptors |
|
Definition
|
|
Term
| Idiopathic Thrombocytopenia Purpura occurs due to |
|
Definition
| an immune response that causes platlet destruction |
|
|
Term
| Thrombocytopenia is platlet drop below |
|
Definition
|
|
Term
| ITP sometimes requires a __________ to control bleeding |
|
Definition
|
|
Term
|
Definition
| trauma, pregnancy related issues,and septicemia |
|
|
Term
| DIC results in consumption of clotting factors centrally which leads to |
|
Definition
|
|
Term
| Endothelial damage is the primary initiator of |
|
Definition
| DIC during sepsis or trauma |
|
|
Term
|
Definition
| removal of underlying cause |
|
|
Term
|
Definition
| genetic mutation of HgBs in the erythrocytes |
|
|
Term
| Sickle Cell Anemia is an __________ disorder |
|
Definition
|
|
Term
| List the types of Sickle Cell Anemia Crisis |
|
Definition
| vasocclusive, sequestration (young children) aplastic, hyperhemolytic (very rare) |
|
|
Term
| When do we see Sickle Cell Anemia present in children? |
|
Definition
|
|
Term
| Iron deficiency anemia in children is r/t |
|
Definition
|
|
Term
| 1/3 of infants with severe IDA will have chronic ____________ due to ____________ |
|
Definition
|
|
Term
| Blood test for Pernicious Anemia includes |
|
Definition
MCV above 100fl
Normal MCHC
Macrocytes on peripheral smear
Low (or normal) Serum Cobalamine
Increase Homocysteine
Methamyloic Acid- most inclusive test |
|
|
Term
| In chronic IDA, serum ferritin will _______ and total iron binding apacity will be _______ |
|
Definition
|
|
Term
| With chronic (primary) ITP |
|
Definition
| IgG autoantibodies are made against platlet associated antigens |
|
|
Term
| During DIC, a person's___________ and __________ levels will increase. |
|
Definition
| Fibrin Degradation Product (FDP) and D-dimer |
|
|
Term
| In DIC, lab values will also indicate |
|
Definition
| low platlet counts, increased clotting times, and presence of FDP |
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