Term
| oxygen doesn't dissolve well in blood so |
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Definition
| it is bound by hemoglobin, it's carrier |
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Term
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Definition
| saturation of hemoglobin (sat or oxygen bound to hgb) (most oxygen in the blood) |
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Definition
| 2% of oxygen in blood, oxygen dissolved in the blood, partial pressure of O2 |
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Definition
| total blood oxygen, sat + PaO2 |
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Definition
| fraction of gas particles |
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Definition
| a heterotetromer made of 2 alpha and 2 beta subunits, has a core heme group where iron binds, can bind 4 oxygen molecules |
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Term
| heme when bound to O2 vs not |
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Definition
| when bound is planar, when not bound has a bend to it |
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Term
| myoglobin vs hemoglobin O2 binding |
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Definition
| myoglobin has very high O2 % bound at low O2 concentrations and has 1 binding site for 1 oxygen molecule (myoglobin binds oxygen and stores it), hgb has less O2 but when 1 molecule of O2 binds gets increased affinity for O2 (cooperativity) |
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Term
| general amount of oxygen in arterial blood |
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Definition
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Definition
| have 75% hgb saturation, there's always a fair amount of saturated hgb, why you dont' need to breathe in CPR |
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Definition
| where cells pick up O2 from bloodstream and use it to make energy |
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Term
| 50% saturation of hgb is at |
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Definition
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Term
| conditions that can alter hgb's affinity for O2 |
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Definition
| inc CO2 down affinity for O2, dec pH down affinity for O2, inc temp down affinity for O2, presence of metabolites like 2,3 DPG causes down affinity for O2 (these conditions are in areas where cellular respiration is happening) (ceullular respiration inc's H ion conc, CO2, temp, intermediates of glycolysis) (so when hgb is found in these areas, it's affinity for O2 is reduced and so it realeases it's O2 which is good and supports cellular metabolism) |
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Term
| places where hgb's affinity for O2 is increased |
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Definition
| lungs, alveoli during gas exchange- reduced CO2, more alkaline, dec temp, dec amounts of metabolic activity, hgb is bound tightly |
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Term
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Definition
| to oxidize fuels (sugars, fats, AAs in starvation) that keep our cells going |
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Term
| breaking down sugars, glucose, fatty acids |
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Definition
| into acetyl-CoA which is used in the Kreb's cycle to get CO2 and electron donors (NADH and FADH2) and GTP, then electron donors used in ETC in mitochondria to form H+ gradient and ATP synthase forms ATP. electrons fed into complex I or II then go down the line of complexes and then oxygen is the final electron acceptor and generates water, CO2 is created which must be exhaled |
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