Term
| What are the 3 possible conformations of a voltage-gated Na channel? |
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Definition
| Closed, open, inactivated |
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Term
| How does pufferfish toxin (TTX) affect action potentials? |
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Definition
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Term
| How do the drugs 4-aminopyridine (4-AP) and TEA affect action potentials? |
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Definition
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Term
| How fast can AP transmit down an unmyelinated axon? |
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Definition
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Term
| What type of cells form myelin? |
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Definition
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Term
| What are the two subtypes of glial cells? |
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Definition
Oligodendrocytes- in CNS
Schwann cells- in PNS |
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Term
| How fast can an AP transmit down a myelinated axon? |
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Definition
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Term
| What 2 diseases attack glial cells? |
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Definition
MS- attacks oligodendrocytes
Guillain-Barre- attacks Schwann cells |
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Term
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Definition
| Motor neuron and all the muscle cells it innervates |
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Term
| What type of drug are sarin and neostigmine? |
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Definition
| Cholinesterase inhibitors |
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Term
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Definition
| Blocks acetylcholine receptors on muscle -> flaccid paralysis |
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|
Term
| How do botulism toxins work? |
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Definition
| Block presynaptic release of Ach |
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Term
| What does hemicholinum do? |
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Definition
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Term
| What does latrotoxin (black widow venom) do? |
|
Definition
| Causes immediate release of all Ach at once -> seizure/spasm followed by flaccid paralysis |
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