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Basic Biopharmaceutics
Terms for chapter 10
21
Biochemistry
Undergraduate 1
03/16/2011

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Term
absorbtion
Definition
the movement of drug from the dosage formulation to the blood
Term
active transport
Definition
the movement of drugs from an area of lower concentration to an area of higher concentration; requires cellular energy
Term
agonists
Definition
drugs that activate receptors to accelerate or slow normal cellular function
Term
antagonists
Definition
drugs that bind with receptors but do not activate them
Term
bioavailability
Definition
the relative amount of an administered dose that reaches the general circulation and the rate at which this occurs
Term
biopharmaceutics
Definition
the study of factors associated with drug products and physiological processes, and the resulting systemic concentration of drugs
Term
biopharmaceutics
Definition
the comparison of bioavability between two dosage forms
Term
disposition
Definition
a term sometimes used to refer to all the ADME processes together
Term
duration of action
Definition
the time the drug processes are above the MEC
Term
elimination
Definition
the processs of metabolsim and excretion
Term
enterohepatic cycling
Definition
the transfer of drugs and their metabolites from the liver to the bile in the gall bladder, then into the intestine, and then back into circulation
Term
enzyme
Definition
a complex protein that catalyzes chemical reactions
Term
enzyme induction
Definition
the increase in hepatic enzyme activity that results in greater metabolism of drugs
Term
enzyme inhibition
Definition
the decrease in hepatic enzyme activity that resuylts in reduced metabolism of drugs
Term
first-pass metabolism
Definition
the substantial degradation of an orally administered drg caused by enzyme metabolism in the liver before the drug reaches the systemic circulation
Term
gastric emptying time
Definition
the time a drug will stay in the stomach before it is mptied into the small intestine
Term
glomerular filtration
Definition
the blood filtering process of the nephron
Term
hydrophilic
Definition
capable of associating with or absorbing water
Term
hydrophobic
Definition
water repelling; cannot associate with water
Term
lipoidal
Definition
fat-like substance
Term
complexation
Definition
when differnet molecules associate or attach to each other
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