Term
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Definition
Cell response remains within homeostasis range
Cell returns to original steady state
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Term
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Definition
Is a Reversible Change
Increased influx of water to cytoplasm, from low conc toxin exposure
After irritant abates, water is pumped out of cell |
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Term
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Definition
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Many complex adaptations and some irreversible cellular events.
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Cannot be avoided or prevented
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May be retarded or its adverse effects minimized.
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Term
| 2 major hypotheses to explain aging are: |
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Definition
1. Wear-and-tear hypothesis
Accounts for decline in fxn or organs that cannot regenerate
2. Genetic hypothesis
Asserts that aging is a genetically predetermined process
This may explain individual aging differences |
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Term
| Cell Death & Necrosis occurs when: |
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Definition
The cell is incapable of further division
No continuing of normal synthetic functions |
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Term
| What happens in a dead cell: |
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Definition
Respiration intake ceases (energy production) - PH lvl drops
Autolysis - cell undergoes self-digestion from low PH lvl
Morphologic changes - fragmented or coagulated cytoplasm
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Term
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Definition
form of cell injury which results in the premature death of cells in living tissue by autolysis
The circumscribed death of cells or tissues is called necrosis. |
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Term
| Secondary necrosis process: |
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Definition
Putrefaction
(wet & dry gangrene) |
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Term
| Necrotic tissue cites a(n) _____ response |
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Definition
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Term
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Definition
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Term
TWO TYPES OF INFLAMMATION: |
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Definition
1. Acute inflammation - Sudden onset, short duration. Swelling
2. Chronic inflammation - The cause of the injury hasn’t been removed, prolonged tissue response
bonus - sub acute (regenerative stage) |
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Term
| Inflammation occurs only in _____ organisms |
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Definition
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Term
| Can inflammation occur post-mortem |
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Definition
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Term
| In cellular death, explain Demolition process |
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Definition
Large phagocytic scavenger cells enter the area to remove debris and damaged tissue
(^macrophages) *macro = large, phage = eat
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Term
| Inflammation is capable of which 2 responses from the body |
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Definition
| Neurovascular and cellular |
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Term
4 CARDINAL SIGNS OF INFLAMMATION |
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Definition
Redness (rubor): more blood to the area
Swelling (tumor): more fluid from increased blood
• Heat (calor): blood carries the heat
• Pain (dolor): increased local pressure on nerves
bonus - disturbed fxn (functio laesa) |
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Term
CAUSES OF CHRONIC INFLAMMATION |
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Definition
Infections - The body has a limited ability to destroy certain organisms
Local or general conditions may impair the body's defence
Insoluble particulate irritants - What microphages cannot digest/easily remove: silica and asbestos.
Hypersensitivity - abnormal excessive reaction to a particular agent
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Term
LOCAL FACTORS INFLUENCING WOUND HEALING |
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Definition
Blood supply
Continued tissue breakdown and inflammation
Direction of the wound
Presence of a large hematoma
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Term
GENERAL FACTORS INFLUENCING WOUND HEALING |
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Definition
Age: Wound healing is faster in the young.
Nutrition: Specially protein deprivation.
Vitamin C deficiency: C is essential in the formation of collagen.
Glucocorticoids: Delay wound contraction and formation of granulation tissue. One of most potent anti inflammatory agents |
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