Binds d-ala-d-ala in cell wall terminus (bactericidal in dividing bacteria)

Tx: exclusively G+ refractory to other antibiotics (MRSA, MRSE, penicillin resistant Pneumococci, Enterococci)

*Gram - resistant to vanco

Sfx: Can get "Red man syndrome" (His release)

lipopeptide that is huge and inserts into membrane to disrupt membrane potential (cidal)

Tx: VRE, MRSA, Drug resistant strep

Sfx: can cause rhabdomyolysis,

Peptide w. long hydrophobic tail, interacts and disrupts cellular membrane (cidal)

Tx: Drug resistant Gram - bacteria

B= topical use

E= ear, oral IV form, but only as last resort (toxic)

Reductive metabolism in anaerobes produces free radicals

Tx: Anaerobic bacteria (Bacteroides, Helicobacter, C. diff)

*Disulfiram effect w/ alcohol

Used alone for prophylaxis or in combo to treat Tuberculosis (inhibits mycolic acid synthesis)

-cidal for growing forms, static for resting forms

*peripheral neuritis (pyridoxine B6 offsets)

Rifamycin, inhibits DNA-dependent RNA pol,

Tx: leprosy, TB, Prophylaxis for meningococcus and H. flu meningitis