Term
| Corynebacterium Diphtheriae Appearence |
|
Definition
|
|
Term
| Corynebacterium Diphtheriae Virulence |
|
Definition
| Diptheria toxin (AB subunit) |
|
|
Term
| Corynebacterium Diphtheriae Disease |
|
Definition
Attach to mucosal surface of URT; not systematic
• Detects iron level to tell if it’s inside organism before acting (DtxR regulator) |
|
|
Term
| Corynebacterium Diptheriae Toxin |
|
Definition
AB subunit toxin
Localized destruction of epithelium due to strong inflammatory response |
|
|
Term
| Corynebacterium Diptheriae Transmission |
|
Definition
|
|
Term
| Corynebacterium Diptheriae Reservoir |
|
Definition
| Normal skin floura and nasopharynx |
|
|
Term
| Corynebacterium Diphtheriae Dx |
|
Definition
| Throat culture on selective medium (tellurite, chocolate tellurite) |
|
|
Term
| Corynebacterium Diphtheriae Tx/Prev |
|
Definition
| Antiotoxin, Ab, Vaccine (diptheria toxoid) |
|
|
Term
| Corynebacterium Diptheriae Mortality |
|
Definition
Mechanical destruction of airway and suffocation
Effects of systemic toxinemia (myocarditis or paralysis) |
|
|
Term
|
Definition
Gram - curved rods
Highly motile
Facultative anaerobe
Oxidase +
Grows on MacConkey agar, even though not an enteric |
|
|
Term
|
Definition
Flagella, mucinase
Adhesins
Cholera toxin |
|
|
Term
|
Definition
Ingestion of Organism (not just toxin)
Requires large dose to infect healthy people
Motile cells penetrate intestianl wall into mucus
Bacteria attach to intestinal epithelium via pili and adnesins
Bacteria then multiple
Do NOT invade cells
Cholera toxin binds to GM1 gangliosides and then enteres epithelial cells
Toxin affect cAMP levels in epithlial cells and causes watery diarrhea (rice water) |
|
|
Term
|
Definition
AB subunit toxin
Type II secretion
Encoded in lysogenic phage, cytotoxic
Toxin expression coordination w/other virulence factors like pili |
|
|
Term
| Vibrio Cholera Transmission |
|
Definition
Oral-fecal route
Ingestion of organisms, not preformed toxin |
|
|
Term
|
Definition
| Contaminated water or food (shellfish) |
|
|
Term
| Vibrio Cholera Treatment/Prevention |
|
Definition
Treatment: fluid and electrolyte replaceent
Prevention: vaccine |
|
|
Term
|
Definition
|
|
Term
| Clostridium Tetani Apperence |
|
Definition
Gram + rods
Anaerobic
Spore-forming |
|
|
Term
| Clostridium Tetani Virulence |
|
Definition
| Tetanus toxin (tetanospasmin) |
|
|
Term
| Clostridium Tetani Disease |
|
Definition
Blocks release of inhibitory neurotransmitters and leads to spastic paralysis
Toxin spread systemically up nerve to CNS or bloodstream |
|
|
Term
|
Definition
|
|
Term
| Clostridium Tetani Transmission |
|
Definition
| Spore injection into deep traumatic wound |
|
|
Term
| Clostridium Tetani Reservoir |
|
Definition
GI tract of animals and humans
Spore found in soil |
|
|
Term
| Clostridium Tetani Treat/prevention |
|
Definition
Antitoxin and antibiotics
Tetanus toxoid vaccine |
|
|
Term
| Clostridium tetani Mortality |
|
Definition
| Resperatory muscle paralysis |
|
|
Term
| Clostridium Botulinum Apperance |
|
Definition
Gram + rods
Anaerobe
Spore-forming |
|
|
Term
| Clostridium Botulinum Virulence |
|
Definition
There are several antigenic distinct types
Extremely potent neurotoxin
Isolates produce single type |
|
|
Term
| Clostridium Botulinum Disease |
|
Definition
Toxin enters cell, bacteria itself doesn't not cause disease
Double/blurred vision
Drooping eyes
Slurred speech
Widespread muscle weakness |
|
|
Term
| Clostritum Botulinum Toxin |
|
Definition
|
|
Term
| Clostridium Botulinum Transmission |
|
Definition
|
|
Term
| Clostridium Botulinum Reservoir |
|
Definition
|
|
Term
| Clostridium Botulinum Treatment/Prevention |
|
Definition
|
|
Term
| Clostridium Botulinum Mortality |
|
Definition
| Respiratory Muscle Paralysis |
|
|
