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Bacteriology BB2
bacteria junk
43
Anthropology
3rd Grade
08/26/2008

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Cards

Term
DRUG: phosphomycin
Definition
inhibits UDP-NAG to UDP NAM in peptidoglycan synthesis
Term
drug: cycloserine
Definition
inhibits synthesis of alanine dipeptide, so can't connect to UDP NAm in peptidoglycan synthesis
Term
Vancomyin
Definition
inhibits peptidoglycan synthesis, sp. can't put disaach to backbone chain; adds itself onto it, so can't add anymore!
Term
drug: bacitrin
Definition
prevents release of P from lipid carrier undecaprenyl (neosporin action)
Term
Polymixins
Definition
Bactericidal!, non-growing cells,basic polypetides w/ fa chains disrupt phosphoethanolamine membranes
Term
drug class: polyenes
Definition
bind to ergosterol, disrupt membrane, ie: nystatin & amphotericin
Term
azoles
Definition
inhibit syn of ergosterol, against fungi
Term
Quinolones and action
Definition
nalidixic acid, norfloxacin, & ciprofloxacin, inhibits nicking activity of DNA gyrase
Term
nalidixic acid
Definition
inhibit DNA synthesis, DNA gyrase
Term
norfloxacin
Definition
dna synthesis inhibitor, DNA gyrase
Term
ciprofloxacin
Definition
DNA synthesis inhibitor, DNA gyrase
Term
novobiocin
Definition
DNA synthesis inhibitor, DNA gyrase
Term
mitomycin
Definition
DNA synthesis inhibitor, not used clinically
Term
metronidazole
Definition
DNA synthesis inhibitor
Term
sulfamides
Definition
DNA synthesis, inhibits folic acid synthesis, by mimicking PABA
Term
trimethoprim
Definition
looks like DHF, inhibits Dihydrofolic reductase,req for purine and pyrididine synthesis. bacterocidial w/ sulfamide.
Term
isoniazid
Definition
TB drug, affects glycolysis, lipid synthesis, nucleic acid synthesis
Term
rifamycin
Definition
TB drug, binds to RNA pol.
also for leprosy, and meningitis prophylaxis
Term
30S ribosome inhibitors
Definition
aminoglycosides, tetracycline, spectinomycin
Term
50S inhibitors
Definition
chloramphenicol, lindamycin, clindamycin, erythomycin (CLEan)
Term
chloramphenicol
Definition
blocks peptidyl transferase; 50S; toxicity
Term
erythryomyin
Definition
Translation, 50S, blocks tRNA moving off P site; a macrolide
Term
1st generation bugs to kill
Definition
PeCk + Klebsiella pn.
Term
Klebsiella pneumonia location and causes?
Definition
usually in GI tract, causes respiratory and UTIs in hospital, severe lobar pneumonia in diabetics, alcholics, COPD patients, bloody currant jelly sputum
Term
Cefazolin
Definition
IV/IM, 1st gen.
Term
Cephalexin
Definition
1st gen, PO
Term
2nd gen cephalosporin coverage
Definition
M.HenPeck
M = Moraxella catarrhis
Term
Cefuroxime
Definition
2nd gen iV/Im
Term
Cefuroxine axetil
Definition
2nd gen, PO
Term
Moraxella catarrhalis causes
Definition
otitis media in children,sinusitis, lower respiratory infections, 2nd cause of COPD exacerbations
Term
what call kill Bacteroides fragilis?
Definition
Chloramphenicol, 2nd ge. Cephamycins (ie: Cefoxitin IV/IM)
Term
Cefoxitin
Definition
IV/IM, 2nd gen cephamycin, kills anaerobes!!
Term
cefotaxime
Definition
3rd gen IV/Im
Term
ceftriaxone
Definition
3rd gen IV/IM
Term
ceftazidime
Definition
antipsuedo. IV/IM, 3rd gen
Term
cefoperazone
Definition
antipseudo, 3 gen, IV/IM
Term
cefepime
Definition
4th gen IV/im
Term
what are 3rd gen cephalosporins good treating for?
Definition
meningitis!
Term
cefixime
Definition
4th gen cephalosporin, ORAL!
Term
Loracarbef
Definition
oral, carbacephem-beta lactam, treat like 2nd cephalosporin to treat respiratory infections
Term
Doripenem
Definition
carbapenem, IV!
Term
cilastatin
Definition
combine w/ imipenem, inhibits DHP, found on brush border of kidney that hydrolyzes beta lactam ring
Term
aztreonam
Definition
monobactam
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