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Bacterial Diseases Acquired Through Respiratory Route
Chapter 4
47
Immunology
Undergraduate 3
02/01/2012

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Term
Pharyngitis
Definition
Sore Throat
Term
Laryngitis
Definition
Swelling of the larynx (voice box) causing hoarseness
Term
Tonsillitis
Definition
Inflammation of the tonsils making it difficult to swallow
Term
Sinusitis
Definition
Inflammation of the sinuses
Term
Otitis Media
Definition
Swelling of the inner ear, causing pressure
Term
Predisposing factors for upper respiratory infections
Definition
  • colds
  • environmental pollutants
  • excessive dryness
  • pollen
  • other allergies
Term
Ways to transmit upper respiratory infections
Definition
  • airborne droplets
  • direct/indirect contact with secretions
  • autoinfection (reinfection with bacteria that is already present)
Term
Sinusitis Characteristics
Definition
  • Most frequently reported chronic desease
  • Caused by many different agents - allergens, structural abnormalities, nasal polyps, second-hand smoke, prior bouts of sinusitis
Term
Ways to Transmit Sinusitis
Definition
  • Autoinfection
  • Airborne droplets
  • Secretion of the nose/throat
Term
Symptoms of Sinusitis
Definition
  • Fever
  • Congestion
  • Sore throat
  • Tooth pain
Term
Treatment and Prevention of Sinusitis
Definition
  • Antibiotics
  • Wash hands
  • Autoimmune maintenence
  • Proper food handling
Term
Streptococcal Sore Throat Characteristics
Definition
  • 95% of cases are caused by Streptococcus pyogenes
  • 20% of children between 6-12 are carriers
  • Otitis media and acute sinusitis are common complaints
Term
Ways to transmit Streptococcal Sore Throat (Pharyngitis)
Definition
  • direct/indirect contact with someone who has it/is a carrier
  • ingestion of contaminated food
Term
Symptoms of Pharyngitis
Definition
  • mild fever
  • severe sore throat
  • swollen glands/tonsils
  • Malaise (discomfort)
  • Loss of appetite
  • Abdominal pain
  • symptoms may not be present in children
Term
Treatment for Pharyngitis
Definition
  • Penicillin/Erythromycin for 10 days
  • early treatment
  • bed rest
Term
Prevention of Pharyngitis
Definition
  • Constant sore throat/fever should see doctor
  • avoid contact with infected
  • proper food handling
  • determine source
  • antibiotics given prophylactically
Term
Characteristics of Rheumatic Fever
Definition
  • Not a bacterial infection
  • always preceded by another form of strep
  • Potentially dangerous
  • Cause of rheumatic heart disease
  • Causation: low immune resistance and hypersensativity
  • More prevalent in lower income groups
Term
Transmission of Rheumatic Fever
Definition
  • Can't be transmitted person to person because it's not a bacterial infection
Term
Symptoms of Rheumatic Fever
Definition
  • Low grade fever
  • Migratory joint pain early
  • Abdominal pain
  • Rash
  • Cardiac involvement
  • Chorea (abnormal, involuntary movement)
Term
Treatment and Prevention of Rheumatic Fever
Definition
  • Penicillin
  • Erythromycin
  • Educate the public
  • Seek treament for strep
Term
Characteristics of Pneumococcal Pneumonia
Definition
  • Most common
  • High frequency among young and old
  • Short incubation period (1-3 days)
  • Non-infectious with antibiotics
Term
Transmission of Pneumococcal Pneumonia
Definition
Direct/indirect contact with respiratory discharge
Term
Symptoms of Pneumococcal Pneumonia
Definition
  • Chills
  • fever
  • chest pain
  • difficult breathing
  • cough
  • Redish sputum (mucus in lungs)
  • pleurisy (sharp breathing pain)
  • Older people may be asymptomatic
Term
Treatment and Prevention of Pneumococcal Pneumonia
Definition
  • Antibiotics
  • Vaccines
  • Avoid crowds during outbreak
Term
Characteristics of Mycoplasmal Pneumonia
Definition
  • "Walking Pneumonia"
  • May last over a month
  • Child under 5 may be asymptomatic
Term
Treatment of Mycoplasmal Pneumonia
Definition
Direct/indirect contact with respiratory secretions
Term
Symptoms of Mycoplasmal Pneumonia
Definition
  • Sudden onset
  • headache
  • malaise
  • sudden coughing
  • substernal pain
  • often not recognized as pneumonia
Term
Treatment and Prevention of Mycoplasmal Pneumonia
Definition
  • Erythromycin
  • Tetracycline
  • No vaccine
  • Proper sanitation
Term
Characteristics of Legionnaire's Disease
Definition
  • Outbreaks traced to faulty cooling systems/excavation sites
  • Unrecognized cause of pneumonia for many years
  • Diagnosed in the states and foreign countries
  • High mortality rates
Term
Transmission of Legionnaire's Disease
Definition
  • Organism lives in soil/water
  • Inhalation of airborne particles
  • No evidence of person-person transfer
Term
Symptoms of Legionnaire's Disease
Definition
  • Sudden/gradual onset
  • Diarrhea
  • Loss of appetite
  • Malaise
  • Myalgia (muscle pain)
  • Headache
  • High fever
  • Chills
  • Gray/blood-streaked sputum
  • Nasea
  • Vomiting
  • Disorientation
  • Bradycardia
Term
Complications for Legionnaire's Disease
Definition
  • Congestive heart failure
  • Acute respiratory failure
  • Renal failure
  • Shock (K/Na are out of balance)
Term
Treatment and Prevention of Legionnaire's Disease
Definition
  • Erythromycin
  • Tetracycline
  • Rifampin
  • No vaccine
  • Dust control at excavation sites
  • Disinfect water supplies
  • implicated cooling systems
Term
Characteristics of Whooping Cough (Pertussis)
Definition
  • Decreased since vaccinations
  • Caused by Bordetella pertussis
  • Dealth likely for infants and elderly
  • Communicable during late incubation
  • Low danger of transmittion 3 weeks after cough begins
  • Only communicable for 5-7 if treated with antibiotics
  • 31% of adult chronic coughers may be carriers
Term
Transmission of Pertussis
Definition
  • Direct contact with droplets
  • Indirect contact with contaminated objects
Term
Symptoms of Pertussis
Definition
  • Catarrhal (cough, loss of appetite, sneezing, listelessness, infected conjunctiva, mild fever)
  • Paroxysmal (Spasmodic coughing, expel mucus, high pitched inspiratory "whoop", vomiting, hernia)
  • Convalescent (Cough may last 1-2 months and be triggered by another respiratory infection)
Term
Treatment and Prevention of Pertussis
Definition
  • Infants are hospitalized
  • Antibiotics are not useful
  • given Nutritional supplements (codine, oxygen therapy)
  • Vaccination
  • Isolate suspected cases
  • Gamma glogulin prophylactically
Term
Characteristics of Diphtheria
Definition
  • Uncommon in 1st world countries
  • Common in 3rd world countries
  • Caused by Corynebacterium diphtheriae (stays in upper respiratory region and produced exotoxin and pseudomembrane which helps toxin spread)
  • Reservoir of infection = humans
  • Can get it again
  • Epidemic in Soviet Union in 1990
Term
Transmission of Diptheria
Definition
Direct by droplets or indirect contact with contaminated objects
Term
Symptoms of Diphtheria
Definition
  • Thick, patchy gray-green membrane over mucous membranes of pharynx, larynx, tonsils, soft palate, and nose
  • fever
  • sore throat
  • raspy cough
  • hoarsenes
  • difficulty breathing
Term
Complications of Diphtheria
Definition
  • Myocarditis
  • Neurologic involvement
  • kidney involvement
Term
Treatment and Prevention of Diphtheria
Definition
  • Diphtheria antitoxin
  • antibiotics
  • vaccination
Term
Characteristics of Tuberculosis
Definition
  • Caused by Mycobacterium tuberculosis
  • In 1900 - 2/1000 died of TB; 20/1000 infected
  • 30,000 new cases each year - may be influenced by AIDS
  • Declared global emergency in 1993 - b/c of AIDS, more imigrants, more poverty/drug use/alcoholism
  • Disease of the lungs, can invade bood stream and affect liver, brain, urogenitlal tract and bones
  • Primary reservoir = human, secondary = cows
Term
Transmission of Tuberculosis
Definition
  • Direct/indirect
  • Inhalation of airborne droplets
  • Prolonged exposure
  • Living in close quarters
Term
Symptoms of Tuberculosis
Definition
  • Usually none at first
  • fatigue
  • weakness
  • appetite loss
  • weight loss
  • night sweats
  • low fever
  • coughing with sputum/pus
  • chest pain
  • bloody sputum
  • organisms are in the lungs
  • reactivation occurs later in life
Term
Treatment and Prevention of Tuberculosis
Definition
  • Isoniazid and Rifampin
  • 9 months of therapy
  • Vaccination and BCG
  • Improved social conditions
  • Source investigation
  • Frequent testing
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